The laboratory focuses on the application of micro- and nanotechnology to tissue repair and regeneration. We aim to improve cellular therapies for liver disease, develop microtechnology tools to systematically study living cells, and design better ways to diagnose and treat cancer.
J&J Lung Cancer Initiative Collaboration
Senior Program Manager: Koch Institute (KI) for Integrative Cancer Research-Johnson and Johnson (J&J) Lung Cancer Initiative Collaboration, to oversee operations and contribute to executing research aims as part of a collaboration focused on research regarding the discovery and development of therapeutics and diagnostics that may be useful in the treatment, prevention, interception and/or diagnosis of diseases specifically focused on lung cancer. Will oversee work conducted jointly in the Jacks, Bhatia, and Irvine laboratories. Responsibilities include supporting/shepherding the program’s vision; supporting overall laboratory operations; hiring, supervising, and enabling development and work of research staff; working with the principal and assistant investigators and collaborative partners, including J&J scientists; coordinating matters of operation and scientific direction; ensuring compliance with MIT EHS and OSHA safety policies and KI, DCM/CAC, and MIT operational policies; optimizing/facilitating research work within the laboratory; networking with animal care and core facilities; writing protocols; assisting with investigator funding requests, reporting on research progress, and assisting with presentations and reports; assisting, writing for, and editing scientific publications; and serving as networking hub between member laboratories and outside partners. Click here for more information.
Research Scientist: Koch Institute (KI) for Integrative Cancer Research-J&J Lung Cancer Initiative Collaboration (multiple positions), to contribute to three KI laboratories involved in research regarding the discovery and development of therapeutics and diagnostics that may be useful treating, preventing, intercepting, and/or diagnosing diseases specifically focused on lung cancer. The Jacks Laboratory will focus on genetic and epigenetic changes accompanying and controlling lung cancer initiation and progression; developing vaccines for disease interception; and the role of inflammation, inflammatory cells, and specific inflammatory mediators in lung cancer development. The Bhatia Laboratory will focus on novel diagnostic and early detection technologies, including protease activity-based nanosensors and explore the utility of these technologies using human genomic data and genetically-engineered mouse models (GEMMs) of lung cancer to detect and stratify disease early enough for interception. The Irvine laboratory will focus on early interception using immunotherapy agents to detect and prophylactically protect from lung cancer and generate novel immune-based drugs and vaccine platforms, especially focused on Kras-mutant lung tumors. These will be tested initially in GEMM models. Will contribute to executing research aims; establishing research strategy; reporting; and planning and writing animal and other protocols, manuscripts, and reports. Click here for more information.
Research Support Associate: Koch Institute for Integrative Cancer Research-J&J Lung Cancer Initiative Collaboration (multiple openings), to provide basic laboratory support for research on the discovery and development of therapeutics and diagnostics that may be useful in the treatment, prevention, interception, and/or diagnosis of diseases specifically focused on lung cancer. Responsibilities include performing data input and basic laboratory support functions; conducting basic lab experiments under close supervision; collecting and processing lab samples or research data; maintaining vendor relationships and equipment service contracts/records; scheduling equipment maintenance/repair; assisting with maintaining laboratory inventory; updating/maintaining laboratory databases; generating standardized reports; following safety standards and procedures; interfacing with MIT environmental health and safety personnel as needed; ensuring biohazard waste disposal occurs following policies and procedures; and performing other duties as needed. May carry out routine literature searches; maintain lab calendar, directories, and mailing lists; and use web software to input, update, and maintain web content. Click here for more information.
Wyss-based Collaboration on Tissue and Organ Regeneration:
Postdoctoral Fellow: We are building an interdisciplinary team to solve tissue and organ regeneration challenges – specifically in the liver, kidney, and vascular lineages. In addition to hiring an intellectual ‘bridge’ senior Staff Scientist who will bring both bench expertise and industry / startup experience to the table, we seek tissue engineering-focused Postdoctoral Fellow to the team, to help drive basic science findings from your future colleagues at Harvard, MIT, and Boston University into pre-clinical animal models, and eventually to patients.
The successful applicants will join an internationally-renowned, multi-disciplinary team of experts in a recently established 3D Organ Engineering Focus Area at the Wyss Institute, located at the Longwood Medical Area in Boston. The Wyss Institute-based team members will serve as a physical hub focused on the translation of groundbreaking work developed by the labs of Prof. Jennifer Lewis (Initiative Co-Lead), Prof. Christopher Chen (Initiative Co-Lead), Prof. Sangeeta Bhatia, Prof. Don Ingber, and Prof. David Mooney.
The Postdoctoral Fellow will work with the Staff Scientist to evaluate early-stage technologies for their potential therapeutic applications, and to implement relevant de-risking strategies needed to move the technology towards clinical applications within tissue fabrication, and organ regeneration. More details and instructions as to how to apply can be found here.
Staff Scientist: In addition to the postdoctoral position, the Wyss-based collaboration is also seeking a Staff Scientist who will function in a management capacity while also performing a significant amount of bench work. More details and instructions as to how to apply can be found here.
Prospective Graduate Students:
The lab is always looking for exceptional students for graduate study. Current MIT graduate students who are interested in doing their thesis at LMRT should contact Dr. Bhatia directly with a curriculum vitae, names of three referees, and a summary of research experience and interests.