Designates equal contribution; Designates co-corresponding authors.
Reticker-Flynn, NE, and Bhatia, SN (2014, in press): Aberrant glycosylation promotes lung cancer metastasis through adhesion to galectins in the metastatic niche. Cancer Discovery. (PDF) doi: 10.1158/2159-8290.CD-13-0760 Featured in Nature
Hanson, KK, March, S, Ng, S, Bhatia, SN, and Mota, MM (2014, in press): In vitro alterations do not reflect a requirement for host cell cycle progression during Plasmodium liver stage infection. Eukaryotic Cell. (PDF) doi: 10.1128/EC.00166-14
Chaturvedi, RR, Stevens, KR, Solorzano, RD, Schwartz, RE, Eyckmans, J, Baranski, JD, Stapleton, S, Bhatia, SN, and Chen, CS (2014, in press): Patterning vascular networks in vivo for tissue engineering applications. Tissue Engineering Part C. (PDF)
Warren, AD, Gaylord, ST, Ngan, KC, Milutinovic, MD, Kwong, GA, Bhatia, SN, and Walt, DR (2014): Disease detection by ultrasensitive quantification of microdosed synthetic urinary biomarkers. JACS. 136(39): 13709-13714. (PDF) doi: 10.1021/ja505676h
Ghosh, D, Bagley, AF, Na, YJ, Birrer, MJ, Bhatia, SN, and Belcher, AM (2014): Deep, noninvasive imaging and surgical guidance of submillimeter tumors using targeted M13-stabilized single-walled carbon nanotubes. PNAS. 111(38):13948-13953. (PDF) doi: 10.1073/pnas.1400821111 Featured in Chemical Research in Toxicology
Ramanan, V, Scull, MA, Sheahan, TP, Rice, CM, and Bhatia, SN (2014): New methods in tissue engineering: improved models for viral infection. Annual Review of Virology. 1:475-499. (PDF) doi: 10.1146/annurev-virology-031413-085437
Lin, KY, Lo, JH, Consul, N, Kwong, GA, and Bhatia, SN (2014): Self-titrating nanocomplexes that restore homeostatic regulation of the coagulation cascade. ACS Nano. 8(9):8776-8785. (PDF) doi:10.1021/nn501129q
Shlomai, A, Schwartz, RE, Ramanan, V, Bhatta, A, de Jonga, YP, Bhatia, SN, and Rice, CM (2014): Modeling host interactions with hepatitis B virus using primary and induced pluripotent stem cell-derived hepatocellular systems. PNAS. 111(33): 12193-12198. (PDF) doi:10.1073/pnas.1412631111
Hui, EE, Li, C, Agrawal, A, and Bhatia, SN (2014): Macro-to-micro interface for the control of cellular organization. Journal of Microelectromechanical Systems. 23(2):391-397. (PDF) doi:10.1109/JMEMS.2013.2278813
Warren, AD, Kwong, GA, Wood, DK, Lin, KY, and Bhatia, SN (2014): Point-of-care diagnostics for noncommunicable diseases using synthetic urinary biomarkers and paper microfluidics. PNAS. (PDF) doi:10.1073/pnas.1314651111
Li, CY, Stevens, KR, Schwartz, RE, Alejandro, BS, Huang, JH, and Bhatia, SN (in press): Micropatterned cell-cell interactions enable functional encapsulation of primary hepatocytes in hydrogel microtissues. Tissue Eng Part A. (PDF) and (Supplementary Information) doi:10.1089/ten.TEA.2013.0667
Olcum S, Cermak N, Wasserman SC, Christine KS, Atsumi H, Payer KR, Shen W, Lee J, Belcher AM, Bhatia SN, and Manalis SR (2014): Weighing nanoparticles in solution at the attogram scale. PNAS. 111(4):1310-1315. (PDF) doi:10.1073/pnas.1318602111
Ng S, March S, Galstian A, Hanson K, Carvalho T, Mota MM, and Bhatia SN (2014): Hypoxia promotes liver stage malaria infection in primary human hepatocytes in vitro. Disease Models & Mechanisms. 7(2): 215-224. (PDF) doi:10.1242/dmm.013490 'In this Issue highlight'
Hauert S, Berman S, Nagpal R, and Bhatia SN (2013): A computational framework for identifying design guidelines to increase the penetration of targeted nanoparticles into tumors. Nano Today. 8: 556-576. (PDF)
Vunjak-Novakovic G, Bhatia S, Chen C, and Hirschi K (2013): HeLiva platform: integrated heart-liver-vascular systems for drug testing in human health and disease. Stem Cell Research & Therapy. 4(Suppl 1):S8-S14. (PDF)
Lin KY, Kwong GA, Warren AD, Wood DK, Bhatia SN (2013): Nanoparticles That Sense Thrombin Activity As Synthetic Urinary Biomarkers of Thrombosis. ACS Nano. 7(10): 9001-9009. doi:10.1021/nn403550c (PDF)
Bagley AF, Hill S, Rogers GS, and Bhatia SN (2013): Plasmonic Photothermal Heating of Intraperitoneal Tumors through the Use of an Implanted Near-Infrared Source. ACS Nano. 7(9): 8089-8097. doi:10.1021/nn4033757 (PDF), Featured in Science Translational Medicine
March, S, Ng, S, Velmurugan, S, Galstian, A, Shan, J, Logan, D, Carpenter, AE, Thomas, D, Sim, BKL, Mota, MM, Hoffman, SL, and Bhatia, SN (2013): A microscale human liver platform that supports the hepatic stages of Plasmodium falciparum and vivax, Cell Host Microbe. 14: 104-115. (PDF) Featured in Nat Revs Microbiology Featured in Science Faculty of 1000 evaluation
Wong IY, Bhatia SN, and Toner M (2013): Nanotechnology: emerging tools for biology and medicine. Genes and Development. 27: 2397-2408. (PDF)
Lo JH, von Maltzahn G, Douglass J, Park J-H, Sailor MJ, and Bhatia SN (2013): Nano particle amplification via photothermal unveiling of cryptic collagen binding sites. Journal of Material Chemicals B. 1: 5235-5240. (PDF)
Shan, J, Schwartz, RE, Ross, NT, Logan, DJ, Duncan, SA, North, TE, Goessling, W, Carpenter, AE, and Bhatia, SN (2013): Identification of small molecules for human hepatocyte expansion and iPS differentiation, Nature Chemical Biology. 9: 514-520. (PDF), Faculty of 1000 evaluation
Desai SP, Bhatia SN, Toner M, and Irimia D. (2013): Mitochondrial localization and the persistent migration of epithelial cancer cells. Biophysical Journal. 104:2077-2088. (PDF)
Baranski, JD, Chaturvedi, RR, Stevens, KR, Eyckmans, J, Carvahlo, B, Solorzano, RD, Yang, MT, Miller, JS, Bhatia, SN, and Chen, CS (2013): Geometric control of vascular networks to enhance engineered tissue integration and function, PNAS. 110:7586-7591. (PDF)
Stevens, KR, Ungrin, MD, Schwartz, RE, Ng, SY, Carvalho, B, Christine, KS, Chaturvedi, R, Li, CY, Zandstra, PW, Chen, CS, and Bhatia, SN (2013): InVERT molding for scalable control of tissue microarchitecture, Nature Communications. 4:1847. (PDF)
Li, CY, Wood, DK, Huang, JH, and Bhatia, SN (2013): Flow-based pipeline for systematic modulation and analysis of 3D tumor microenvironments, Lab Chip, 13:1969-78. (PDF)
Kwong, GA, von Maltzahn, G, Murugappan, G, Abudayyeh, O, Mo, S, Papayannopoulos, IA, Sverdlov, DY, Liu, SB, Warren, AD, Popov, Y, Schuppan, and Bhatia, SN (2012): Mass-encoded synthetic biomarkers for multiplexed urinary monitoring of disease. Nature Biotechnology. 1: 63-70. (PDF)
Prestwich, GD, Bhatia, SN, Breuer, CK, Dahl, SLM, Mason, C, McFarland, R, McQuillan, DJ, Sackner-Bernstein, J, Schox, WE, and Trounson, A (2012): What Is the Greatest Regulatory Challenge in the Translation of Biomaterials to the Clinic? Science Translational Medicine, 4(160): 160cm14. (PDF) Featured in Science
El-Haibi, CP, Bell, GW, Zhang, J, Collmann, AY, Wood, DK, Scherber, CM, Csizmadia, E, Mariani, O, Zhu, C, Campagne, A, Toner, M, Bhatia, SN, Irimia, D, Vincent-Salomon, A, and Karnoub, AE (2012): Critical role for lysyl oxidase in mesenchymal stem cell-driven breast cancer malignancy. PNAS. 109(43): 17460-17465. (PDF)
Reticker-Flynn, NE, Braga Malta, DF, Winslow, MM, Lamar, JM, Xu, MJ, Underhill, GH, Hynes, RO, Jacks, TE, and Bhatia, SN (2012): A combinatorial extracellular matrix platform identifies cell-extracellular matrix interactions that correlate with metastasis. Nature Communications. 3: 1122. (PDF) Supplemental Material Featured in Nature
Danino, T, Lo, J, Prindle, A, Hasty, J and Bhatia, SN (2012): In vivo gene expression dynamics of tumor-targeted bacteria. ACS Synthetic Biology. 1(10): 465-470. (PDF)
Bhatia SN, Frangioni JV, Hoffman RM, Iafrate JA, and Polyak K (2012): The challenges posed by cancer heterogeneity. Nature Biotechnology. 30(7): 604-610. (PDF)
Ren, Y, Hauert, S, Lo, J, and Bhatia, SN (2012): Identification and characterization of receptor-specific peptides for siRNA delivery. ACS Nano. 6(10):8620-8631. (PDF)
Underhill, GH, Galie, P, Chen, CS, and Bhatia, SN (2012): Bioengineering methods for analysis of cells in vitro. Annual Review of Cell and Developmental Biology. 28: 385-410. (PDF)
Prindle, A, Selimkhanov, J, Danino, T, Samayoa, P, Goldberg, A, Bhatia, SN, and Hasty, J (2012): Genetic circuits in Salmonella typhimuriu. ACS Synthetic Biology. 1(10): 458-464. (PDF)
Ren, Y, Cheung, HW, von Maltzhan, G, Agrawal, A, Cowley, GS, Weir, BA, Boehm, JS,
Tamayo, P, Karst, AM, Liu, JF, Hirsch, MS, Mesirov, JP, Drapkin, R, Root, DE, Lo, J,
Fogal, V, Ruoslahti, E, Hahn, WE, and Bhatia, SN(2012): Targeted
tumor-penetrating siRNA nanocomplexes for credentialing the ovarian cancer oncogene
ID4. Science Translational Medicine, 4(147): 147ra112.
Faculty of 1000 evaluation
* Featured in ACS Nano
Nijhawan, D, Zack, TI, Ren, Y, Strickland, MR, Lamothe, R, Schumacher, SE, Tsherniak, A, Besche, HC, Rosenbluh, J, Shehata, S, Cowley, GS, Weir, BA, Goldberg, AL, Mesirov, JP, Root, DE, Bhatia, SN, Beroukhim, R, and Hahn, WC (2012): Cancer vulnerabilities unveiled by genomic loss. Cell, 150(4): 842-854. (PDF)
Miller, JS, Stevens, KR, Yang, MT, Baker, BM, Nguyen, DT, Cohen, DM, Toro, E, Chen, SS, Galie, PA, Yu, X, Chaturvedi, R, Bhatia, SN, and Chen, CS (2012): Rapid casting of patterned vascular networks for perfusable engineered three-dimensional tissues. Nature Materials. 11:768-774. (PDF), Supplemental Material, Supplemental Movie, Faculty of 1000 evaluation
Lin, KY, Bagley, AF, Zhang, AY, Karl, DL, Yoon, SS, and Bhatia, SN(2012): Gold nanorod photothermal therapy in a genetically engineered mouse model of soft tissue sarcoma. Nano LIFE. 1:277-287. (PDF)
Wood, DK, Soriano, A, Mahadevan, L, Higgins, JM, and Bhatia, SN (2012): A biophysical indicator of vaso-occlusive risk in sickle cell disease. Science Translational Medicine: 4, 123ra26. (PDF) STM podcast Featured in Nature Medicine Featured in Lab on a Chip
Schwartz, RE, Trehan, K, Andrus, L, Sheahan, TP, Ploss, A, Duncan, SA, Rice, CM, and Bhatia, SN (2012): Modeling hepatitis C virus infection using human induced pluripotent stem cells. PNAS, 109: 2544-2548. (PDF) Featured in Nature Methods Featured in Disease Models & Mechanisms Faculty of 1000 evaluation
Cheung, HW, Cowley, GS, Weir, BA, Boehm, JS, Rusin, S, Scott, JA, East, A, Ali, LD, Lizotte, PH, Wong, TC, Jiang, G, Hsiao, J, Mermel, CH, Getz, G, Barretina, J, Gopal, S, Tamayo, P, Gould, J, Tsherniak, A, Stransky, N, Luo, B, Ren, Y, Drapkin, R, Bhatia, SN, Mesirov, JP, Garraway, LA, Meyerson, M, Lander, ES, Root, DE, Hahn, WC (2011): Systematic investigation of genetic vulnerabilities across cancer cell lines reveals lineage-specific dependencies in ovarian cancer. PNAS, 108(30): 12372-12377 (PDF)
Andrus, L, Marukian, S, Jones, CT, Catanese, MT, Sheahan, TP, Schoggins, JW, Barry, WT, Dustin, LB, Trehan, K, Ploss, A, Bhatia, SN, Rice, CM (2011): Expression of paramyxovirus V proteins promotes replication and spread of hepatitis C virus in cultures of primary human fetal liver cells. Hepatology, 54: 1901-1912. (PDF)
Danino, T, Volfson, D, Bhatia, SN, Tsimring, L, Hasty, J (2011): In-silico patterning of vascular mesenchymal cells in three dimensions. PLoS ONE 6(5): e20182. (PDF)
Singh, N, Karambelkar, A, Gu, L, Lin, K, Miller, JS, Chen, CS, Sailor, MJ, and Bhatia, SN (2011): Bioresponsive mesoporous silica nanoparticles for triggered drug release. Journal of the American Chemical Society, 133: 19582-19585. (PDF)
Li, CY, Wood, DK, Hsu, CM, Bhatia, SN (2011): DNA-templated assembly of droplet-derived PEG microtissues. Lab Chip, 11(17): 2967-2975. (PDF)
Chen, AA, Thomas, DK, Ong, LL, Schwartz, RE, Golub, TR, Bhatia, SN (2011):
Humanized mice with ectopic artificial liver tissues. PNAS, 106: 11842-11847.
Faculty of 1000 evaluation,
Featured in Hepatology
* Top 20 Most Read in July 2011
von Maltzahn, G, Park, J-H, Lin, KY, Singh, N, Schwφppe, C, Mesters, R, Berdel, WE, Ruoslahti, E, Sailor, MJ, Bhatia, SN (2011): Nanoparticles that communicate in vivo to amplify tumour targeting. Nature Materials, 10: 545-552. (PDF) Featured in Nature Materials Featured in Nature Rev Cancer
Goldberg, MS, Xing, D, Ren, Y, Orsulic, S, Bhatia, SN, and Sharp, PA (2011): Nanoparticle-mediated delivery of siRNA targeting Parp1 extends survival of mice bearing tumors derived from Brca1-deficient ovarian cancer cells. PNAS, 108: 745-750. (PDF), Faculty of 1000 evaluation
Poon, Z, Chen, S, Engler, AC, Lee, H-I, Atas, E, von Maltzahn, G, Bhatia, SN, and Hammond, PT (2010). Ligand-clustered "patchy" nanoparticles for modulated cellular uptake and in vivo tumor targeting. Angew Chem Int Ed Engl, 49: 7266-7270. (PDF)
Chen, AA, Underhill, GH, and Bhatia, SN (2010): Multiplexed, high-throughput analysis of 3D microtissue suspensions. Integrative Biology, 2: 517-527. (PDF)
Singh, N, Agrawal, A, Leung, AKL, Sharp, PA, and Bhatia, SN (2010): Effect of Nanoparticle Conjugation on Gene Silencing by RNA Interference. Journal of the American Chemical Society, 132: 8241-8243. (PDF), Faculty of 1000 evaluation
Ruoslahti,E, Bhatia, SN, and Sailor, MJ (2010): Targeting of drugs and nanoparticles to tumors, J. Cell Biol., 188: 759-768. (PDF)
Park, J-H, von Maltzahn, G, Ong, L, Centrone, A, Hatton, TA, Ruoslahti, E, Bhatia , SN, and Sailor, MJ (2010): Cooperative nanoparticles for tumor detection and photothermally triggered drug delivery. Advanced Materials, 22: 880-885. (PDF)
Albrecht, DR, Underhill, GH, Resnikoff, J, Mendelson, A, Bhatia, SN, and Shah , JV (2010): Microfluidics-integrated time-lapse imaging for analysis of cellular dynamics. Integrative Biology, 2: 278-287. (PDF)
Chesler, NC, Barabino, GA, Bhatia, SN, Richards-Kortum, RR, (2010): The pipeline still leaks and more than you think: A status report on gender diversity in biomedical engineering, Annals of Biomedical Engineering, 38: 1928-1935. (PDF)
Jones, CT, Catanese, MT, Law, LMJ, Khetani, SR, Syder, AJ, Ploss, A, Oh, TS, Schoggins, JW, MacDonald, MR, Bhatia, SN, and Rice, CM (2010): Real-time imaging of hepatitis C virus infection using a fluorescent cell-based reporter system. Nature Biotechnology. 28, 167-171. (PDF), Faculty of 1000 evaluation
Ploss, A, Khetani, SR, Jones, CT, Sydera, AJ, Trehan, K, Gaysinskaya, VA, Mua, K, Ritola, K, Rice, CM, and Bhatia, SN (2010): Persistent hepatitis C virus infection in microscale primary human hepatocyte cultures. PNAS. 107: 3141-3145. (PDF)
Harris, TJ, Green, JJ, Fung, PW, Langer, R, Anderson, DG, and Bhatia, SN (2010): Tissue-specific gene delivery via nanoparticle coating. Biomaterials. 31: 998-1006. (PDF)
Park,J-H, von Maltzahn, G, Xu, MJ, Fogal, V, Kotamraju,VR, Ruoslahti, E, Bhatia, SN, & Sailor, MJ (2010): Cooperative nanomaterial system to sensitize, target, and treat tumors. PNAS. 107: 981-986. (PDF)
Aptekar, JW, Cassidy, MC, Johnson, AC, Barton, RA, Lee, M, Ogier, AC, Vo, C, Anahtar, MN, Ren, Y, Bhatia, SN, Ramanathan, C, Cory, DG, Hill, AL, Mair, RW, Rosen, MS, Walsworth, RL, and Marcus, CM (2009): Silicon nanoparticles as hyperpolarized magnetic resonance imaging agents. ACS Nano, 3:4003-4008. (PDF)
DasGupta, D, von Maltzahn, G, Ghosh, S, Bhatia, SN, Das, SK, and Chakraborty, S (2009) Probing nanoantenna-directed photothermal destruction of tumors using noninvasive laser irradiation, Applied Physics Letters, 95, 233701. (PDF)
Agrawal, A, Min, D-H, Singh, N, Zhu, H, Birjiniuk, A,von Maltzahn, G, Harris, T, Xing, D, Woolfenden, S, Sharp, P, Charest, A, and Bhatia, SN (2009): Functional delivery of siRNA in mice using dendriworms. ACS Nano. 3: 24952504. (PDF) Supplemental Material
Simberg, D ,Park, J-H, Karmali, PP, Zhang, W-M, Merkulov, S, McCrae, K, Bhatia, SN, Sailor, M and Ruoslahti, E (2009): Differential proteomics analysis of the surface heterogeneity of dextran iron oxide nanoparticles and the implications for their in vivo clearance. Biomaterials, 30: 3926-3933. (PDF)
March, S, Hui, EE, Underhill, GH, Khetani, S, and Bhatia, SN (2009). Microenvironmental regulation of the sinusoidal endothelial cell phenotype in vitro. Hepatology, 50: 920-928. (PDF), Supplemental Material, Faculty of 1000 evaluation
von Maltzahn, G, Centrone, A.,Park,J-H, Ramanathan, R, Sailor, MJ, Hatton, TA, and Bhatia, SN (2009): SERS-Coded gold nanorods as a multifunctional platform for densely multiplexed near-infrared imaging and photothermal heating. Advanced Materials, 21: 3175-3180. (PDF)
von Maltzahn, G., Park, J-H, Agrawal, A, Bandaru, NK, Das, SK, Sailor, MJ, and Bhatia, SN (2009): Computationally-guided photothermal tumor therapy using long-circulating gold nanorod antennas. Cancer Research. 69: 3892-3900. (PDF) Supplemental Material
Park, J-H, von Maltzahn, G, Zhang, L, Derfus, AM, Simberg, D, Harris, TJ, Ruoslahti, E, Bhatia, SN, and Sailor, MJ (2009): Systematic surface engineering of magnetic nanoworms for in vivo tumor targeting. Small. 5(6):694-700. (PDF)
Park, J-H, Gu, L, von Maltzahn, G, Ruoslahti, E, Bhatia, SN , and Sailor, MJ (2009): Biodegradable luminescent porous silicon nanoparticles for in vivo applications. Nature Materials, 8: 331-336. (PDF) Highlighted as a Nature Material 'Landmark Article'
Higgins , J, Eddington, D , Bhatia, SN, Mahadevan, L (2009): Statistical dynamics of flowing red blood cells by morphological image processing. PLoS Computational Biology. 5 (2), e1000288. (PDF)
Chen, AA[†], Khetani, SR[†], Lee, S, Bhatia, SN, Van Vliet, KJ
(2009): Modulation of hepatocyte phenotype in vitro via chemomechanical tuning of
polyelectrolyte multilayers. Biomaterials 30: 1113-1120.
[†] These authors contributed equally.
Alvarez SD, Derfus, AM, Schwartz MP, Bhatia, SN, Sailor, MJ (2008): The compatibility of hepatocytes with chemically modified porous silicon with reference to in vitro biosensors. Biomaterials, 30: 26-34. (PDF)
Park, J-H, von Maltzahn, G, Ruoslahti, E, Bhatia, SN, Sailor, MJ (2008): Micellar hybrid nanoparticles for simultaneous magnetofluorescent imaging and drug delivery. Angewandte Chemie,47: 7284-7288. (PDF)
Von Maltzahn, G, Ren, Y, Park, J-H, Min, D-H, Kotamraju, V R, Jayakumar, J, Fogal, V, Sailor, MJ, Ruoslahti, E, Bhatia, SN (2008): In vivo tumor cell targeting with "click" nanoparticles. Bioconjugate Chemistry, 19: 1570-1578. PMCID: PMC2538627. 10 most-accessed articles of 2008, Bioconjugate Chemistry (PDF)
Harris, TJ, von Maltzahn, G, Lord, ME, Park, J-H, Agrawal, A, Min, D-H, Sailor, MJ, Bhatia, SN (2008): Protease-Triggered Unveiling of Bioactive Nanoparticles. Small, 4:1307-1312. (PDF)
Park, J-H, von Maltzahn, G, Schwartz, MP, Ruoslahti, E, Bhatia, SN, Sailor, MJ (2008, in press): Magnetic iron oxide nanoworms for tumor targeting and imaging. Advanced Materials. (PDF) Supplemental Material
News article in Analytical Chemistry 'Analytical Currents' section: Improved superparamagnetic nanoparticles for targeting and imaging; Analytical Chemistry, July 1 2008, page 4777. (PDF)
Flaim CJ, Teng D, Chien S, and Bhatia, SN (2008). Combinatorial signaling
microenvironments for studying stem cell fate. Stem Cells and Development, 17: 29-39.
* For higher resolution version of the images in the pdf file, please click on the images in the document. A window with the high resolution images should open in your internet browser.
Derfus, AM, Chen, AA, Min, D-H, Ruoslahti, E, Bhatia, SN (2007): Targeted quantum dot conjugates for siRNA delivery. Bioconjugate Chemistry, 18(5): 1391-1396. 10 most-accessed articles of 2008, Bioconjugate Chemistry (PDF)
Hui E and Bhatia SN (2007). Silicon microchips for manipulating cell-cell interaction. J Vis Exp, 7: 268. (PDF)
Albrecht, DR, Underhill, GH, Mendelson, A, Bhatia, SN (2007). Multiphase electropatterning of cells and biomaterials. Lab on a Chip. 7: 702-709. (PDF)
von Maltzahn, G [†], Min, D-H [†], Zhang, Y, Park, J-H, Harris, TJ,
Sailor, M, Bhatia, SN (2007): Nanoparticle self-assembly directed by
antagonistic kinase and phosphatase activities. Advanced Materials. 19(21): 3579-3583.
[†] These authors contributed equally.
Underhill GH and Bhatia SN (2007): High-throughput analysis of signals regulating stem cell fate and function. Current Opinion in Chemical Biology. 11: 357-366. (PDF)
Evans, AR, Euteneuer, S, Chavez, E, Mullen, LM, Hui, EE, Bhatia, SN, and Ryan, AF (2007): Laminin and fibronectin modulate inner ear spiral ganglion neurite outgrowth in an in vitro alternate choice assay. Developmental Neurobiology, 67(13): 1721-1730. (PDF)
Derfus, AM, von Maltzahn, G, Harris, TJ, Duza, T, Vecchio, KS, Ruoslahti, E, Bhatia, SN (2007). Remotely triggered release from magnetic nanoparticles. Advanced Materials. 19: 3932-3936. (PDF)
von Maltzahn, G, Harris, TJ, Park, J-H, Schmidt, AJ, Sailor, MJ, and
Bhatia, SN (2007). Nanoparticle self-assembly gated by logical proteolytic
triggers. Journal of the American Chemical Society, 129: 6064-6065.
* Featured on NCI Cancer News
* Featured in Nature Nanotechnology Research Highlights
Hui EE and Bhatia SN (2007). Micromechanical control of cell-cell interactions.
PNAS. 104: 5722-5726.
Faculty of 1000 evaluation
* Featured in Analytical Chemistry, Biosphere section Deciphering Cellular Conversations. Vol. 79, No. 11: June 1, 2007. p 3962. (PDF)
* Featured in Nature Methods, Research Highlights, 'A Gentle Touch for Cells'. Vol. 4(6), June 2007, p. 472. (PDF)
Hui, EE and Bhatia, SN (2007). Microscale control of cell contact and spacing via three-component surface patterning. Langmuir, 23: 4103-4107. (PDF)
Simberg, D, Duza, T, Park, J-H, Essler, M, Pilch, J, Zhang, L, Derfus, AM, Yang, M, Hoffman, RM, Bhatia, SN, Sailor, MJ and Ruoslahti1, E (2007). Biomimetic amplification of nanoparticle homing to tumors. PNAS, 104: 932-936. (PDF)
Liu Tsang, V, Chen, AA, Cho, LM, Jadin, KD, Sah, RL, DeLong, S, West, JL, and Bhatia, SN (2007): Fabrication of 3D hepatic tissues by additive photopatterning of cellular hydrogels. FASEB Journal. 21: 790-801. (PDF), Supplemental Movie
Underhill, GH*, Chen, AA*, Albrecht, DR, Bhatia, SN (2007): Assessment
of hepatocellular function within PEG hydrogels. Biomaterials, 28: 256-270.
*These authors contributed equally.
Khetani, S.R., and Bhatia, S.N. (2006) Engineering tissues for in vitro applications. Current Opinion in Biotechnology, 17: 524-531. (PDF)
Allen, JW, Khetani, SR, Johnson, RS, and Bhatia, SN. (2006) In vitro liver tissue model established from transgenic mice: Role of HIF-1alpha on hypoxic gene expression. Tissue Engineering, 12(11): 3135-3147. (PDF)
Park J-H, Derfus AM, Segal E, Vecchio KS, Bhatia SN, Sailor MJ (2006): Local heating of discrete droplets using magnetic porous silicon-based photonic crystals. Journal of the American Chemical Society, 128(24): 7938-7946. (PDF)
Schwartz MP, Derfus AM, Alvarez SD, Bhatia SN, and Sailor MJ (2006): The
smart petri dish: A nanostructured photonic crystal for real-time monitoring of living
cells. Langmuir, 22: 7084-7090.
This article featured on the cover of Langmuir, in Technology Review, and in UCSD news.
Albrecht, DR, Underhill, GH, Wassermann, TB, Sah, RL, Bhatia, SN (2006): Probing the role of multicellular organization in 3D microenvironments. Nature Methods. 3: 369-375. (PDF), Supplement 6 - Movie, Supplement 7 - Movie, Faculty of 1000 evaluation
Harris TJ*, von Maltzahn, G*, Derfus AM, Rouslahti E, Bhatia SN (2006):
Proteolytic Actuation of Nanoparticle Self-Assembly. Agnewandte Chemie International
Edition. 41(19): 3161-3165.
Faculty of 1000 evaluation
*These authors contributed equally.
This article was featured on the cover of Angewandte Chemie, in Nanotoday, and in MIT News.
Liu VA, and Bhatia SN (2006): 3-D Scaffold Fabrication: Application to
Hepatic Tissue Engineering, in Scaffolding in Tissue Engineering. PX Ma and J.
Elisseeff, eds., Marcel Dekker, 609-620.
This article featured in Nature Research Highlights, MIT News, and as Access Science Image of the Week.
Li YY, Cunin F, Link JR, Gao T, Betts RE, Reiver SH, Chin V, Bhatia SN, Sailor MJ (2003): Polymer Replicas of Photonic Porous Silicon For Sensing and Drug Delivery Applications. Science 299: 2045-2047. (PDF)
Gopalan SM, Flaim C, Bhatia SN, Hoshijima M, Knoel R, Chien KR, Omens JH, and McCulloch AD (2003): Anisotropic Stretch-induced Hypertrophy in Neonatal Ventricular Myocytes Micropatterned on Deformable Elastomers. Biotechnology & Bioengineering 81(5): 578-587. (PDF)
Allen J W, and Bhatia SN (2003) Formation of Steady-State Oxygen Gradients In vitro: Application to Liver Zonation. Biotechnology and Bioengineering 82: 253-262. (PDF)
Vozzi G, Flaim CJ, Ahluwalia A, and Bhatia SN (2003): Fabrication of PLGA Scaffolds Using Soft Lithography and Microsyringe Deposition. Biomaterials 24: 2533-2540. (PDF)