†Designates equal contribution; ‡Designates co-corresponding authors.

Reticker-Flynn, NE, and Bhatia, SN (2015): Aberrant glycosylation promotes lung cancer metastasis through adhesion to galectins in the metastatic niche. Cancer Discovery 5(2): 1-14. (PDF) doi: 10.1158/2159-8290.CD-13-0760 Featured in Nature Featured in Nature Reviews Cancer

Hanson, KK, March, S, Ng, S, Bhatia, SN, and Mota, MM (2015): In vitro alterations do not reflect a requirement for host cell cycle progression during Plasmodium liver stage infection. Eukaryotic Cell 14(1): 96-103 (PDF) doi: 10.1128/EC.00166-14


Itoe, MA, Sampaio, JL, Cabal, GG, Real, E, Zuzarte-Luis, V, March, S, Bhatia, SN, Frischknecht, F, Thiele, C, Shevchenko, A, and Mota, MM (2014): Host cell phosphatidylcholine is a key mediator of malaria parasite survival during liver stage infection. Cell Host & Microbe 16(6): 778–786. (PDF) doi: 10.1016/j.chom.2014.11.006

Lin, KY, Kwon, EJ, Lo, JH, and Bhatia, SN (2014, in press): Drug-induced amplification of nanoparticle targeting to tumors. NanoToday 9(5): 550-559. (PDF) doi: 10.1016/j.nantod.2014.09.001

Chaturvedi, RR, Stevens, KR, Solorzano, RD, Schwartz, RE, Eyckmans, J, Baranski, JD, Stapleton, S, Bhatia, SN, and Chen, CS (2014, in press): Patterning vascular networks in vivo for tissue engineering applications. Tissue Engineering Part C. (PDF) doi: 10.1089/ten.TEC.2014.0258

Warren, AD†, Gaylord, ST†, Ngan, KC, Milutinovic, MD, Kwong, GA, Bhatia, SN‡, and Walt, DR‡ (2014): Disease detection by ultrasensitive quantification of microdosed synthetic urinary biomarkers. JACS 136(39): 13709-13714. (PDF) doi: 10.1021/ja505676h

Ghosh, D†, Bagley, AF†, Na, YJ, Birrer, MJ, Bhatia, SN‡, and Belcher, AM‡ (2014): Deep, noninvasive imaging and surgical guidance of submillimeter tumors using targeted M13-stabilized single-walled carbon nanotubes. PNAS 111(38):13948-13953. (PDF) doi: 10.1073/pnas.1400821111 Featured in Chemical Research in Toxicology

Ramanan, V†, Scull, MA†, Sheahan, TP, Rice, CM, and Bhatia, SN (2014): New methods in tissue engineering: improved models for viral infection. Annual Review of Virology 1:475-499. (PDF) doi: 10.1146/annurev-virology-031413-085437

Lin, KY, Lo, JH, Consul, N, Kwong, GA, and Bhatia, SN (2014): Self-titrating nanocomplexes that restore homeostatic regulation of the coagulation cascade. ACS Nano 8(9):8776-8785. (PDF) doi:10.1021/nn501129q

Bhatia, SN, and Ingber, DE (2014): Microfluidic organs-on-chips. Nature Biotechnology 32(8):760-772 (PDF) doi:10.1038/nbt.2989

Shlomai, A†, Schwartz, RE†, Ramanan, V†, Bhatta, A, de Jonga, YP, Bhatia, SN‡, and Rice, CM‡ (2014): Modeling host interactions with hepatitis B virus using primary and induced pluripotent stem cell-derived hepatocellular systems. PNAS 111(33): 12193-12198. (PDF) doi:10.1073/pnas.1412631111

Hauert, S, Bhatia, SN (2014): Mechanisms of cooperation in cancer nanomedicine: towards systems nanotechnology. Trends in Biotechnology 32(9): 448-455. (PDF) doi:10.1016/j.tibtech.2014.06.010

Bhatia, SN, Underhill, GH, Zaret, KS, and Fox, IJ (2014, cover feature): Cell and tissue engineering for liver disease. Sci. Transl. Med. 6, 245sr2. (PDF) doi: 10.1126/scitranslmed.3005975

Hui, EE, Li, C, Agrawal, A, and Bhatia, SN (2014): Macro-to-micro interface for the control of cellular organization. Journal of Microelectromechanical Systems 23(2):391-397. (PDF) doi:10.1109/JMEMS.2013.2278813

Warren, AD†, Kwong, GA†, Wood, DK†, Lin, KY, and Bhatia, SN (2014): Point-of-care diagnostics for noncommunicable diseases using synthetic urinary biomarkers and paper microfluidics. PNAS 111(10): 3671-6. (PDF) doi:10.1073/pnas.1314651111

Li, CY, Stevens, KR, Schwartz, RE, Alejandro, BS, Huang, JH, and Bhatia, SN (in press): Micropatterned cell-cell interactions enable functional encapsulation of primary hepatocytes in hydrogel microtissues. Tissue Eng Part A 20(15-16): 2200-2212. (PDF) and (Supplementary Information) doi:10.1089/ten.TEA.2013.0667

Schwartz, RE, Fleming, HE, Khetani, SR, and Bhatia, SN (2014): Pluripotent stem cell-derived hepatocyte-like cells. Biotechnology Advances 32(2): 504-513. (PDF) doi:10.1016/j.biotechadv.2014.01.003

Olcum S†, Cermak N†, Wasserman SC, Christine KS, Atsumi H, Payer KR, Shen W, Lee J, Belcher AM, Bhatia SN, and Manalis SR (2014): Weighing nanoparticles in solution at the attogram scale. PNAS 111(4):1310-1315. (PDF) doi:10.1073/pnas.1318602111

Ng S, March S, Galstian A, Hanson K, Carvalho T, Mota MM, and Bhatia SN (2014): Hypoxia promotes liver stage malaria infection in primary human hepatocytes in vitro. Disease Models & Mechanisms 7(2): 215-224. (PDF) doi:10.1242/dmm.013490 'In this Issue highlight'


Hauert S, Berman S, Nagpal R, and Bhatia SN (2013): A computational framework for identifying design guidelines to increase the penetration of targeted nanoparticles into tumors. Nano Today. 8: 556-576. (PDF)

Vunjak-Novakovic G, Bhatia S, Chen C, and Hirschi K (2013): HeLiva platform: integrated heart-liver-vascular systems for drug testing in human health and disease. Stem Cell Research & Therapy. 4(Suppl 1):S8-S14. (PDF)

Lin KY, Kwong GA, Warren AD, Wood DK, Bhatia SN (2013): Nanoparticles That Sense Thrombin Activity As Synthetic Urinary Biomarkers of Thrombosis. ACS Nano. 7(10): 9001-9009. doi:10.1021/nn403550c (PDF)

Bagley AF, Hill S, Rogers GS, and Bhatia SN (2013): Plasmonic Photothermal Heating of Intraperitoneal Tumors through the Use of an Implanted Near-Infrared Source. ACS Nano. 7(9): 8089-8097. doi:10.1021/nn4033757 (PDF), Featured in Science Translational Medicine

Danino T, Prindle A, Hasty J, and Bhatia SN (2013): Measuring Growth and Gene Expression Dynamics of Tumor-Targeted S. Typhimurium Bacteria. Journal Visualized Expts. 77:e50540. (PDF) (video)

March, S, Ng, S, Velmurugan, S, Galstian, A, Shan, J, Logan, D, Carpenter, AE, Thomas, D, Sim, BKL, Mota, MM, Hoffman, SL, and Bhatia, SN (2013): A microscale human liver platform that supports the hepatic stages of Plasmodium falciparum and vivax, Cell Host Microbe. 14: 104-115. (PDF) Featured in Nat Revs Microbiology Featured in Science Faculty of 1000 evaluation

Wong IY, Bhatia SN, and Toner M (2013): Nanotechnology: emerging tools for biology and medicine. Genes and Development. 27: 2397-2408. (PDF)

Lo JH, von Maltzahn G, Douglass J, Park J-H, Sailor MJ, and Bhatia SN (2013): Nano particle amplification via photothermal unveiling of cryptic collagen binding sites. Journal of Material Chemicals B. 1: 5235-5240. (PDF)

Shan, J, Schwartz, RE, Ross, NT, Logan, DJ, Duncan, SA, North, TE, Goessling, W, Carpenter, AE, and Bhatia, SN (2013): Identification of small molecules for human hepatocyte expansion and iPS differentiation, Nature Chemical Biology. 9: 514-520. (PDF), Faculty of 1000 evaluation

Desai SP, Bhatia SN, Toner M, and Irimia D. (2013): Mitochondrial localization and the persistent migration of epithelial cancer cells. Biophysical Journal. 104:2077-2088. (PDF)

Baranski, JD, Chaturvedi, RR, Stevens, KR, Eyckmans, J, Carvahlo, B, Solorzano, RD, Yang, MT, Miller, JS, Bhatia, SN, and Chen, CS (2013): Geometric control of vascular networks to enhance engineered tissue integration and function, PNAS. 110:7586-7591. (PDF)

Stevens, KR, Ungrin, MD, Schwartz, RE, Ng, SY, Carvalho, B, Christine, KS, Chaturvedi, R, Li, CY, Zandstra, PW, Chen, CS, and Bhatia, SN (2013): InVERT molding for scalable control of tissue microarchitecture, Nature Communications. 4:1847. (PDF)

Li, CY, Wood, DK, Huang, JH, and Bhatia, SN (2013): Flow-based pipeline for systematic modulation and analysis of 3D tumor microenvironments, Lab Chip, 13:1969-78. (PDF)


Kwong, GA, von Maltzahn, G, Murugappan, G, Abudayyeh, O, Mo, S, Papayannopoulos, IA, Sverdlov, DY, Liu, SB, Warren, AD, Popov, Y, Schuppan, and Bhatia, SN (2012): Mass-encoded synthetic biomarkers for multiplexed urinary monitoring of disease. Nature Biotechnology. 1: 63-70. (PDF)

Prestwich, GD, Bhatia, SN, Breuer, CK, Dahl, SLM, Mason, C, McFarland, R, McQuillan, DJ, Sackner-Bernstein, J, Schox, WE, and Trounson, A (2012): What Is the Greatest Regulatory Challenge in the Translation of Biomaterials to the Clinic? Science Translational Medicine, 4(160): 160cm14. (PDF) Featured in Science

El-Haibi, CP, Bell, GW, Zhang, J, Collmann, AY, Wood, DK, Scherber, CM, Csizmadia, E, Mariani, O, Zhu, C, Campagne, A, Toner, M, Bhatia, SN, Irimia, D, Vincent-Salomon, A, and Karnoub, AE (2012): Critical role for lysyl oxidase in mesenchymal stem cell-driven breast cancer malignancy. PNAS. 109(43): 17460-17465. (PDF)

Reticker-Flynn, NE, Braga Malta, DF, Winslow, MM, Lamar, JM, Xu, MJ, Underhill, GH, Hynes, RO, Jacks, TE, and Bhatia, SN (2012): A combinatorial extracellular matrix platform identifies cell-extracellular matrix interactions that correlate with metastasis. Nature Communications. 3: 1122. (PDF) Supplemental Material Featured in Nature

Danino, T, Lo, J, Prindle, A, Hasty, J and Bhatia, SN (2012): In vivo gene expression dynamics of tumor-targeted bacteria. ACS Synthetic Biology. 1(10): 465-470. (PDF)

Bhatia SN, Frangioni JV, Hoffman RM, Iafrate JA, and Polyak K (2012): The challenges posed by cancer heterogeneity. Nature Biotechnology. 30(7): 604-610. (PDF)

Ren, Y, Hauert, S, Lo, J, and Bhatia, SN (2012): Identification and characterization of receptor-specific peptides for siRNA delivery. ACS Nano. 6(10):8620-8631. (PDF)

Underhill, GH, Galie, P, Chen, CS, and Bhatia, SN (2012): Bioengineering methods for analysis of cells in vitro. Annual Review of Cell and Developmental Biology. 28: 385-410. (PDF)

Prindle, A, Selimkhanov, J, Danino, T, Samayoa, P, Goldberg, A, Bhatia, SN, and Hasty, J (2012): Genetic circuits in Salmonella typhimuriu. ACS Synthetic Biology. 1(10): 458-464. (PDF)

Ren, Y, Cheung, HW, von Maltzhan, G, Agrawal, A, Cowley, GS, Weir, BA, Boehm, JS, Tamayo, P, Karst, AM, Liu, JF, Hirsch, MS, Mesirov, JP, Drapkin, R, Root, DE, Lo, J, Fogal, V, Ruoslahti, E, Hahn, WE, and Bhatia, SN(2012): Targeted tumor-penetrating siRNA nanocomplexes for credentialing the ovarian cancer oncogene ID4. Science Translational Medicine, 4(147): 147ra112. (PDF), Faculty of 1000 evaluation
* Featured in ACS Nano

Nijhawan, D, Zack, TI, Ren, Y, Strickland, MR, Lamothe, R, Schumacher, SE, Tsherniak, A, Besche, HC, Rosenbluh, J, Shehata, S, Cowley, GS, Weir, BA, Goldberg, AL, Mesirov, JP, Root, DE, Bhatia, SN, Beroukhim, R, and Hahn, WC (2012): Cancer vulnerabilities unveiled by genomic loss. Cell, 150(4): 842-854. (PDF)

Miller, JS, Stevens, KR, Yang, MT, Baker, BM, Nguyen, DT, Cohen, DM, Toro, E, Chen, SS, Galie, PA, Yu, X, Chaturvedi, R, Bhatia, SN, and Chen, CS (2012): Rapid casting of patterned vascular networks for perfusable engineered three-dimensional tissues. Nature Materials. 11:768-774. (PDF), Supplemental Material, Supplemental Movie, Faculty of 1000 evaluation

Lin, KY, Bagley, AF, Zhang, AY, Karl, DL, Yoon, SS, and Bhatia, SN(2012): Gold nanorod photothermal therapy in a genetically engineered mouse model of soft tissue sarcoma. Nano LIFE. 1:277-287. (PDF)

Wood, DK, Soriano, A, Mahadevan, L, Higgins, JM, and Bhatia, SN (2012): A biophysical indicator of vaso-occlusive risk in sickle cell disease. Science Translational Medicine: 4, 123ra26. (PDF) STM podcast Featured in Nature Medicine Featured in Lab on a Chip

Schwartz, RE, Trehan, K, Andrus, L, Sheahan, TP, Ploss, A, Duncan, SA, Rice, CM, and Bhatia, SN (2012): Modeling hepatitis C virus infection using human induced pluripotent stem cells. PNAS, 109: 2544-2548. (PDF) Featured in Nature Methods Featured in Disease Models & Mechanisms Faculty of 1000 evaluation


Cheung, HW, Cowley, GS, Weir, BA, Boehm, JS, Rusin, S, Scott, JA, East, A, Ali, LD, Lizotte, PH, Wong, TC, Jiang, G, Hsiao, J, Mermel, CH, Getz, G, Barretina, J, Gopal, S, Tamayo, P, Gould, J, Tsherniak, A, Stransky, N, Luo, B, Ren, Y, Drapkin, R, Bhatia, SN, Mesirov, JP, Garraway, LA, Meyerson, M, Lander, ES, Root, DE, Hahn, WC (2011): Systematic investigation of genetic vulnerabilities across cancer cell lines reveals lineage-specific dependencies in ovarian cancer. PNAS, 108(30): 12372-12377 (PDF)

Andrus, L, Marukian, S, Jones, CT, Catanese, MT, Sheahan, TP, Schoggins, JW, Barry, WT, Dustin, LB, Trehan, K, Ploss, A, Bhatia, SN, Rice, CM (2011): Expression of paramyxovirus V proteins promotes replication and spread of hepatitis C virus in cultures of primary human fetal liver cells. Hepatology, 54: 1901-1912. (PDF)

Danino, T, Volfson, D, Bhatia, SN, Tsimring, L, Hasty, J (2011): In-silico patterning of vascular mesenchymal cells in three dimensions. PLoS ONE 6(5): e20182. (PDF)

Singh, N, Karambelkar, A, Gu, L, Lin, K, Miller, JS, Chen, CS, Sailor, MJ, and Bhatia, SN (2011): Bioresponsive mesoporous silica nanoparticles for triggered drug release. Journal of the American Chemical Society, 133: 19582-19585. (PDF)

Li, CY, Wood, DK, Hsu, CM, Bhatia, SN (2011): DNA-templated assembly of droplet-derived PEG microtissues. Lab Chip, 11(17): 2967-2975. (PDF)

Chen, AA, Thomas, DK, Ong, LL, Schwartz, RE, Golub, TR, Bhatia, SN (2011): Humanized mice with ectopic artificial liver tissues. PNAS, 106: 11842-11847. (PDF), Faculty of 1000 evaluation, Featured in Hepatology
* Top 20 Most Read in July 2011

von Maltzahn, G, Park, J-H, Lin, KY, Singh, N, Schwφppe, C, Mesters, R, Berdel, WE, Ruoslahti, E, Sailor, MJ, Bhatia, SN (2011): Nanoparticles that communicate in vivo to amplify tumour targeting. Nature Materials, 10: 545-552. (PDF) Featured in Nature Materials Featured in Nature Rev Cancer

Goldberg, MS, Xing, D, Ren, Y, Orsulic, S, Bhatia, SN, and Sharp, PA (2011): Nanoparticle-mediated delivery of siRNA targeting Parp1 extends survival of mice bearing tumors derived from Brca1-deficient ovarian cancer cells. PNAS, 108: 745-750. (PDF), Faculty of 1000 evaluation


Poon, Z, Chen, S, Engler, AC, Lee, H-I, Atas, E, von Maltzahn, G, Bhatia, SN, and Hammond, PT (2010). Ligand-clustered "patchy" nanoparticles for modulated cellular uptake and in vivo tumor targeting. Angew Chem Int Ed Engl, 49: 7266-7270. (PDF)

Chen, AA, Underhill, GH, and Bhatia, SN (2010): Multiplexed, high-throughput analysis of 3D microtissue suspensions. Integrative Biology, 2: 517-527. (PDF)

Singh, N, Agrawal, A, Leung, AKL, Sharp, PA, and Bhatia, SN (2010): Effect of Nanoparticle Conjugation on Gene Silencing by RNA Interference. Journal of the American Chemical Society, 132: 8241-8243. (PDF), Faculty of 1000 evaluation

Ruoslahti,E, Bhatia, SN, and Sailor, MJ (2010): Targeting of drugs and nanoparticles to tumors, J. Cell Biol., 188: 759-768. (PDF)

Wood, DK, Weingeist, DM, Bhatia, SN, and Engelward, BP (2010): Single cell trapping and DNA damage analysis using microwell arrays. PNAS, 107: 10008-10013. (PDF), Faculty of 1000 evaluation

Park, J-H, von Maltzahn, G, Ong, L, Centrone, A, Hatton, TA, Ruoslahti, E, Bhatia , SN, and Sailor, MJ (2010): Cooperative nanoparticles for tumor detection and photothermally triggered drug delivery. Advanced Materials, 22: 880-885. (PDF)

Albrecht, DR, Underhill, GH, Resnikoff, J, Mendelson, A, Bhatia, SN, and Shah , JV (2010): Microfluidics-integrated time-lapse imaging for analysis of cellular dynamics. Integrative Biology, 2: 278-287. (PDF)

Chesler, NC, Barabino, GA, Bhatia, SN, Richards-Kortum, RR, (2010): The pipeline still leaks and more than you think: A status report on gender diversity in biomedical engineering, Annals of Biomedical Engineering, 38: 1928-1935. (PDF)

Jones, CT, Catanese, MT, Law, LMJ, Khetani, SR, Syder, AJ, Ploss, A, Oh, TS, Schoggins, JW, MacDonald, MR, Bhatia, SN, and Rice, CM (2010): Real-time imaging of hepatitis C virus infection using a fluorescent cell-based reporter system. Nature Biotechnology. 28, 167-171. (PDF), Faculty of 1000 evaluation

Ploss, A, Khetani, SR, Jones, CT, Sydera, AJ, Trehan, K, Gaysinskaya, VA, Mua, K, Ritola, K, Rice, CM, and Bhatia, SN (2010): Persistent hepatitis C virus infection in microscale primary human hepatocyte cultures. PNAS. 107: 3141-3145. (PDF)

Harris, TJ, Green, JJ, Fung, PW, Langer, R, Anderson, DG, and Bhatia, SN (2010): Tissue-specific gene delivery via nanoparticle coating. Biomaterials. 31: 998-1006. (PDF)

Park,J-H, von Maltzahn, G, Xu, MJ, Fogal, V, Kotamraju,VR, Ruoslahti, E, Bhatia, SN, & Sailor, MJ (2010): Cooperative nanomaterial system to sensitize, target, and treat tumors. PNAS. 107: 981-986. (PDF)


Aptekar, JW, Cassidy, MC, Johnson, AC, Barton, RA, Lee, M, Ogier, AC, Vo, C, Anahtar, MN, Ren, Y, Bhatia, SN, Ramanathan, C, Cory, DG, Hill, AL, Mair, RW, Rosen, MS, Walsworth, RL, and Marcus, CM (2009): Silicon nanoparticles as hyperpolarized magnetic resonance imaging agents. ACS Nano, 3:4003-4008. (PDF)

DasGupta, D, von Maltzahn, G, Ghosh, S, Bhatia, SN, Das, SK, and Chakraborty, S (2009) Probing nanoantenna-directed photothermal destruction of tumors using noninvasive laser irradiation, Applied Physics Letters, 95, 233701. (PDF)

Agrawal, A, Min, D-H, Singh, N, Zhu, H, Birjiniuk, A,von Maltzahn, G, Harris, T, Xing, D, Woolfenden, S, Sharp, P, Charest, A, and Bhatia, SN (2009): Functional delivery of siRNA in mice using dendriworms. ACS Nano. 3: 2495–2504. (PDF) Supplemental Material

Simberg, D ,Park, J-H, Karmali, PP, Zhang, W-M, Merkulov, S, McCrae, K, Bhatia, SN, Sailor, M and Ruoslahti, E (2009): Differential proteomics analysis of the surface heterogeneity of dextran iron oxide nanoparticles and the implications for their in vivo clearance. Biomaterials, 30: 3926-3933. (PDF)

March, S, Hui, EE, Underhill, GH, Khetani, S, and Bhatia, SN (2009). Microenvironmental regulation of the sinusoidal endothelial cell phenotype in vitro. Hepatology, 50: 920-928. (PDF), Supplemental Material, Faculty of 1000 evaluation

von Maltzahn, G, Centrone, A.,Park,J-H, Ramanathan, R, Sailor, MJ, Hatton, TA, and Bhatia, SN (2009): SERS-Coded gold nanorods as a multifunctional platform for densely multiplexed near-infrared imaging and photothermal heating. Advanced Materials, 21: 3175-3180. (PDF)

von Maltzahn, G., Park, J-H, Agrawal, A, Bandaru, NK, Das, SK, Sailor, MJ, and Bhatia, SN (2009): Computationally-guided photothermal tumor therapy using long-circulating gold nanorod antennas. Cancer Research. 69: 3892-3900. (PDF) Supplemental Material

Park, J-H, von Maltzahn, G, Zhang, L, Derfus, AM, Simberg, D, Harris, TJ, Ruoslahti, E, Bhatia, SN, and Sailor, MJ (2009): Systematic surface engineering of magnetic nanoworms for in vivo tumor targeting. Small. 5(6):694-700. (PDF)

Park, J-H, Gu, L, von Maltzahn, G, Ruoslahti, E, Bhatia, SN , and Sailor, MJ (2009): Biodegradable luminescent porous silicon nanoparticles for in vivo applications. Nature Materials, 8: 331-336. (PDF) Highlighted as a Nature Material 'Landmark Article'

Higgins , J, Eddington, D , Bhatia, SN, Mahadevan, L (2009): Statistical dynamics of flowing red blood cells by morphological image processing. PLoS Computational Biology. 5 (2), e1000288. (PDF)

Chen, AA[†], Khetani, SR[†], Lee, S, Bhatia, SN, Van Vliet, KJ (2009): Modulation of hepatocyte phenotype in vitro via chemomechanical tuning of polyelectrolyte multilayers. Biomaterials 30: 1113-1120. (PDF)
[†] These authors contributed equally.


Alvarez SD, Derfus, AM, Schwartz MP, Bhatia, SN, Sailor, MJ (2008): The compatibility of hepatocytes with chemically modified porous silicon with reference to in vitro biosensors. Biomaterials, 30: 26-34. (PDF)

Khetani, SR, Chen, AA, Ranscht, B,and Bhatia, SN (2008): T-cadherin modulates hepatocyte functions in vitro. FASEB Journal, 22:3678-3775. (PDF) Supplemental Material

Park, J-H, von Maltzahn, G, Ruoslahti, E, Bhatia, SN, Sailor, MJ (2008): Micellar hybrid nanoparticles for simultaneous magnetofluorescent imaging and drug delivery. Angewandte Chemie,47: 7284-7288. (PDF)

Von Maltzahn, G, Ren, Y, Park, J-H, Min, D-H, Kotamraju, V R, Jayakumar, J, Fogal, V, Sailor, MJ, Ruoslahti, E, Bhatia, SN (2008): In vivo tumor cell targeting with "click" nanoparticles. Bioconjugate Chemistry, 19: 1570-1578. PMCID: PMC2538627. 10 most-accessed articles of 2008, Bioconjugate Chemistry (PDF)

Harris, TJ, von Maltzahn, G, Lord, ME, Park, J-H, Agrawal, A, Min, D-H, Sailor, MJ, Bhatia, SN (2008): Protease-Triggered Unveiling of Bioactive Nanoparticles. Small, 4:1307-1312. (PDF)

Park, J-H, von Maltzahn, G, Schwartz, MP, Ruoslahti, E, Bhatia, SN, Sailor, MJ (2008, in press): Magnetic iron oxide nanoworms for tumor targeting and imaging. Advanced Materials. (PDF) Supplemental Material

News article in Analytical Chemistry 'Analytical Currents' section: Improved superparamagnetic nanoparticles for targeting and imaging; Analytical Chemistry, July 1 2008, page 4777. (PDF)

Flaim CJ, Teng D, Chien S, and Bhatia, SN (2008). Combinatorial signaling microenvironments for studying stem cell fate. Stem Cells and Development, 17: 29-39. (PDF)
* For higher resolution version of the images in the pdf file, please click on the images in the document. A window with the high resolution images should open in your internet browser.

Khetani, SR, and Bhatia, SN (2008): Microscale human liver tissue for drug development. Nature Biotechnology, 26 (1): 120-126. (PDF), Faculty of 1000 evaluation

Derfus, AM, Chen, AA, Min, D-H, Ruoslahti, E, Bhatia, SN (2007): Targeted quantum dot conjugates for siRNA delivery. Bioconjugate Chemistry, 18(5): 1391-1396. 10 most-accessed articles of 2008, Bioconjugate Chemistry (PDF)


Hui E and Bhatia SN (2007). Silicon microchips for manipulating cell-cell interaction. J Vis Exp, 7: 268. (PDF)

Albrecht, DR, Underhill, GH, Mendelson, A, Bhatia, SN (2007). Multiphase electropatterning of cells and biomaterials. Lab on a Chip. 7: 702-709. (PDF)

von Maltzahn, G [†], Min, D-H [†], Zhang, Y, Park, J-H, Harris, TJ, Sailor, M, Bhatia, SN (2007): Nanoparticle self-assembly directed by antagonistic kinase and phosphatase activities. Advanced Materials. 19(21): 3579-3583. (PDF)
[†] These authors contributed equally.

Underhill GH and Bhatia SN (2007): High-throughput analysis of signals regulating stem cell fate and function. Current Opinion in Chemical Biology. 11: 357-366. (PDF)

Evans, AR, Euteneuer, S, Chavez, E, Mullen, LM, Hui, EE, Bhatia, SN, and Ryan, AF (2007): Laminin and fibronectin modulate inner ear spiral ganglion neurite outgrowth in an in vitro alternate choice assay. Developmental Neurobiology, 67(13): 1721-1730. (PDF)

Higgins JM, Eddington DT, Bhatia S, Mahadevan L (2007). Sickle-cell vasoocclusion and rescue in a microfluidic device. PNAS. 104(51): 20496-20500. (PDF), Faculty of 1000 evaluation

Derfus, AM, von Maltzahn, G, Harris, TJ, Duza, T, Vecchio, KS, Ruoslahti, E, Bhatia, SN (2007). Remotely triggered release from magnetic nanoparticles. Advanced Materials. 19: 3932-3936. (PDF)

von Maltzahn, G, Harris, TJ, Park, J-H, Schmidt, AJ, Sailor, MJ, and Bhatia, SN (2007). Nanoparticle self-assembly gated by logical proteolytic triggers. Journal of the American Chemical Society, 129: 6064-6065. (PDF), Supplemental Material
* Featured on NCI Cancer News
* Featured in Nature Nanotechnology Research Highlights

Hui EE and Bhatia SN (2007). Micromechanical control of cell-cell interactions. PNAS. 104: 5722-5726. (PDF), Supplemental Movie, Faculty of 1000 evaluation
* Featured in Analytical Chemistry, Biosphere section Deciphering Cellular Conversations. Vol. 79, No. 11: June 1, 2007. p 3962. (PDF)
* Featured in Nature Methods, Research Highlights, 'A Gentle Touch for Cells'. Vol. 4(6), June 2007, p. 472. (PDF)

Hui, EE and Bhatia, SN (2007). Microscale control of cell contact and spacing via three-component surface patterning. Langmuir, 23: 4103-4107. (PDF)

Simberg, D, Duza, T, Park, J-H, Essler, M, Pilch, J, Zhang, L, Derfus, AM, Yang, M, Hoffman, RM, Bhatia, SN, Sailor, MJ and Ruoslahti1, E (2007). Biomimetic amplification of nanoparticle homing to tumors. PNAS, 104: 932-936. (PDF)

Liu Tsang, V, Chen, AA, Cho, LM, Jadin, KD, Sah, RL, DeLong, S, West, JL, and Bhatia, SN (2007): Fabrication of 3D hepatic tissues by additive photopatterning of cellular hydrogels. FASEB Journal. 21: 790-801. (PDF), Supplemental Movie

Underhill, GH*, Chen, AA*, Albrecht, DR, Bhatia, SN (2007): Assessment of hepatocellular function within PEG hydrogels. Biomaterials, 28: 256-270. (PDF)
*These authors contributed equally.


Khetani, S.R., and Bhatia, S.N. (2006) Engineering tissues for in vitro applications. Current Opinion in Biotechnology, 17: 524-531. (PDF)

Allen, JW, Khetani, SR, Johnson, RS, and Bhatia, SN. (2006) In vitro liver tissue model established from transgenic mice: Role of HIF-1alpha on hypoxic gene expression. Tissue Engineering, 12(11): 3135-3147. (PDF)

Park J-H, Derfus AM, Segal E, Vecchio KS, Bhatia SN, Sailor MJ (2006): Local heating of discrete droplets using magnetic porous silicon-based photonic crystals. Journal of the American Chemical Society, 128(24): 7938-7946. (PDF)

Schwartz MP, Derfus AM, Alvarez SD, Bhatia SN, and Sailor MJ (2006): The smart petri dish: A nanostructured photonic crystal for real-time monitoring of living cells. Langmuir, 22: 7084-7090. (PDF)

This article featured on the cover of Langmuir, in Technology Review, and in UCSD news.

Albrecht, DR, Underhill, GH, Wassermann, TB, Sah, RL, Bhatia, SN (2006): Probing the role of multicellular organization in 3D microenvironments. Nature Methods. 3: 369-375. (PDF), Supplement 6 - Movie, Supplement 7 - Movie, Faculty of 1000 evaluation

Harris TJ*, von Maltzahn, G*, Derfus AM, Rouslahti E, Bhatia SN (2006): Proteolytic Actuation of Nanoparticle Self-Assembly. Agnewandte Chemie International Edition. 41(19): 3161-3165. (PDF), Faculty of 1000 evaluation
*These authors contributed equally.
This article was featured on the cover of Angewandte Chemie, in Nanotoday, and in MIT News.

Liu VA, and Bhatia SN (2006): 3-D Scaffold Fabrication: Application to Hepatic Tissue Engineering, in Scaffolding in Tissue Engineering. PX Ma and J. Elisseeff, eds., Marcel Dekker, 609-620. (PDF)
This article featured in Nature Research Highlights, MIT News, and as Access Science Image of the Week.


Chen, AA*, Derfus, AM*, Khetani, SR, Bhatia, SN (2005): Quantum Dots to Monitor RNAi Delivery and Improve Gene Silencing. Nucleic Acids Research, 33 (22): e190 (PDF) *These authors contributed equally

This paper featured on the 'NAR Hot Papers' webpage.

Flaim, C., Chien, S, Bhatia, S.N. (2005): An Extracellular Matrix Microarray for Probing Cellular Differentiation. Nature Methods 2(2): 119-125 (PDF + Supplemental Material )

Allen, JW, Khetani, SR, Bhatia, SN (2005): In Vitro Zonation and Toxicity in a Hepatocyte Bioreactor. Toxicological Sciences 84: 110-119 (PDF)

Allen JW, Johnson RS, Bhatia SN. (2005): Hypoxic inhibition of 3-methylcholanthrene-induced CYP1A1 expression is independent of HIF-1alpha . Toxicology Letters 155: 151–159 (PDF)

Albrecht, D.R., V.Liu Tsang, Sah, R.L. and Bhatia, S.N. (2005): Photo-and Electropatterning of Live Cellular Arrays Within Hydrogels. Lab on a Chip 5(1):111-118 (PDF)


Dorvee J, Derfus AM, Bhatia SN, Sailor MJ. (2004) Manipulation of Liquid Droplets using Amphiphilic, Magnetic 1-D Photonic Crystal Chaperones." Nature Materials 3: 896 - 899 (PDF)

This article featured in Nature News and Views: Magnetic Chaperones for Droplets Chin V Sanga S, Taupin P, Scheel J, Gage FG, Bhatia SN (2004): A Microfabricated Platform for Studying Stem Cell Fates. Biotechnology and Bioengineering 88(3): 399-415 (PDF)

Albrecht D. Sah R, Bhatia SN (2004): Geometric and Material Determinants of Patterning Efficiency by Dielectrophoresis. Biophysical Journal 87(4): 2131-2147 (PDF)

Liu V, Bhatia SN (2004): 3D Tissue Fabrication. Advanced Drug Delivery 56: 1635-1647 (PDF)

Bhatia SN (2004), "Cell and Tissue-Based Sensors", WTEC (World Technology Evaluation Center) Panel Report on International Research and Development in Biosensing, 35-42

Khetani S, Szulgit G, Del Rio J, Barlow C, Bhatia SN (2004): Exploring Mechanisms Of Stromal-Epithelial Cell Interactions Using Gene Expression Profiling. Hepatology 40(3): 545-554 (PDF)

Derfus A, Chan W, Bhatia SN (2004): Intracellular Delivery of Quantum Dots for Live Cell Labeling and Organelle Tracking. Advanced Materials 16(12): 961-966. (PDF)

Derfus A, Chan W, Bhatia SN (2004): Probing the Cytotoxicity of Semiconductor Quantum Dots. Nanoletters 4(1): 11-18 (PDF)

Lin P, Chan W, Badylak S, Bhatia SN (2004): Assessing Liver-Derived Biomatrix for Hepatic Tissue Engineering. Tissue Engineering 10 (7/8): 1046-1053 (PDF)


Li YY, Cunin F, Link JR, Gao T, Betts RE, Reiver SH, Chin V, Bhatia SN, Sailor MJ (2003): Polymer Replicas of Photonic Porous Silicon For Sensing and Drug Delivery Applications. Science 299: 2045-2047. (PDF)

Gopalan SM, Flaim C, Bhatia SN, Hoshijima M, Knoel R, Chien KR, Omens JH, and McCulloch AD (2003): Anisotropic Stretch-induced Hypertrophy in Neonatal Ventricular Myocytes Micropatterned on Deformable Elastomers. Biotechnology & Bioengineering 81(5): 578-587. (PDF)

Allen J W, and Bhatia SN  (2003) Formation of Steady-State Oxygen Gradients In vitro: Application to Liver Zonation. Biotechnology and Bioengineering 82: 253-262. (PDF)

Ozkan M, Pisanic T, Barlow C, Esener, S, and Bhatia SN (2003): Electro-Optical Platform for the Manipulation of Live Cells. Langmuir 19: 1532-1538. (PDF), Faculty of 1000 evaluation

Vozzi G, Flaim CJ, Ahluwalia A, and Bhatia SN (2003): Fabrication of PLGA Scaffolds Using Soft Lithography and Microsyringe Deposition. Biomaterials 24: 2533-2540. (PDF)


Liu, V.A. and Bhatia, SN(2002): Three-Dimensional Photopatterning of Hydrogels Containing Living Cells. Biomedical Microdevices 4(4): 257-66 (PDF)

Akerman ME*, Chan WCW*, Laakkonen P, Bhatia SN and Ruoslahti E (2002): Nanocrystal Targeting In Vivo. PNAS 99(20): 12617-12621 *These authors contributed equally. (PDF)

Cunin F, Schmedake TA, Link JR, Koh, J, Bhatia SN and Sailor MJ (2002): Biomolecular screening with encoded porous silicon photonic crystals. Nature Materials 1(1): 39-41 (PDF)

Allen J W, and Bhatia SN (2002) Improving the Next Generation of Bioartificial Liver Devices. Seminars in Cell and Developmental Biology 13(6): 447-454 (PDF)

Allen J, Hassenein T, and Bhatia SN (2002): Engineering Liver Therapies for the Future. Tissue Engineering, 8(5): 725-737 (PDF)

Ozkan M, Bhatia SN, and Esener, SC (2002): Optical Addressing of Polymer Beads in Microdevices. Sensors and Materials, 14(4): 189-97 (PDF)

Heyman GD, Bryn M, and Bhatia SN (2002): Gender and Achievement-Related Beliefs among Engineering Students: A Social-Cognitive Perspective. The Journal of Women and Minorities in Science and Engineering 8 (1): 41-52 (PDF)

Vozzi G, Flaim CJ, Ahluwalia A, Bianchi F, and Bhatia SN (2002): Microfabricated PLGA Scaffolds: A Comparative Study for Application to Tissue Engineering. Materials Science & Engineering C, 20(1-2): 43-47 (PDF)

Liu VA, Jastromb WE, and Bhatia SN (2002): Engineering protein and cell adhesivity using PEO-terminated triblock polymers.  Journal of Biomedical Materials Research 60(1): 126-134 (PDF)


Ozkan M, Ozkan CS, Kibar O, Wang MM, Bhatia SN, and Esener SC (2001): Heterogeneous Integration through Electrokinetic Migration: IEEE Journal of EMB Magazine, 20(6): 144-151 (PDF)

Ozkan M, Esener SC, and Bhatia SN (2001): Electrokinetic Assembly of Microsphere and Cellular Arrays. Materials Research Society Joint Proceedings: Biomaterials for Drug Delivery and Tissue Engineering 662 NN6.4 (PDF)

Chin V, Collins B, Sailor M, and Bhatia SN (2001): Compatibility of Primary Hepatocytes on Nanoporous Silicon. Advanced Materials 13(24): 1877-1880 (PDF)

Allen J, Hassenein T, and Bhatia SN (2001): Advances in Bioartificial Liver Devices. Hepatology 34(3): 447-455 (PDF)

Song L, Bhatia SN, Hu YL, Shiu YT, Li YS, Usami S, and Chien S (2001): Effects of Morphological Patterning on Endothelial Cell Migration. Biorheology 38: 101-108 (PDF)

1994 - 2000

Behnia K, Bhatia SN, Jastromb N, Balis U, Sullivan S, Yarmush M, and Toner M (2000): Xenobiotic Metabolism by Cultured Primary Porcine Hepatocytes. Tissue Engineering 6(5): 467-479 (PDF)

Bhatia SN, and Chen C (1999): Tissue Engineering at the Micro-Scale. Biomedical Microdevices 2(2): 131-144 (PDF)

Bhatia SN, Balis U, Yarmush ML, and Toner M (1999): Effect of Cell-Cell Interactions in Preservation of Cellular Phenotype: Co-Cultivation of Hepatocytes and Non-Parenchymal Cells. FASEB J 13(14): 1883-1900 (PDF)

Bhatia SN, Suri V, Budny A, and Krauss C (1999): Prenatal detection and mapping of a distal 8p deletion associated with congenital heart disease. Prenatal Diagnosis 19(9): 863-7 (PDF)

Balis UJ, Behnia K, Dwarkanath B, Bhatia SN, Sullivan SJ, Yarmush ML, and Toner M (1999): Oxygen Consumption Characteristics of Porcine Hepatocytes. Metabolic Engineering 1: 49-62 (PDF)

Ledezma GA, Folch A, Bhatia SN, Balis UJ, Yarmush ML, and Toner M (1999): Numerical Model of Fluid Flow and Oxygen Transport in a Radial-Flow Microchannel Containing Hepatocytes. Journal of Biomechanical Engineering 121: 58-64

Bhatia SN, Balis U, Yarmush ML, and Toner M (1998): Micropatterning Cells in Tissue Engineering. J Biomaterials Science, Polymer Edition 9(11): 1137-1160 (PDF)

Bhatia SN, Balis U, Yarmush ML, and Toner M (1998): Microfabrication of Hepatocyte/Fibroblast Co-Cultures: Role of Homotypic Cell Interactions. Biotechnology Progress 14: 378-387 (PDF)

Bhatia SN, Yarmush ML, and Toner M (1997): Engineered Substrates for Controlling Cell-Cell Interactions. 1997 Advances in Heat and Mass Transfer in Biotechnology ASME HTD-355, BED- 37: 99-103 (PDF)

Bhatia SN, Yarmush ML, and Toner M (1997): Controlling Cell Interactions by Micropatterning in Co-Cultures: Hepatocytes and 3T3 Fibroblasts. Journal of Biomedical Materials Research, 34 (2): 189-199 (PDF)

Bhatia SN, Toner M, Foy BD, Rotem A, O'Neil KM, Tompkins RG, and Yarmush ML (1996): Zonal Liver Cell Heterogeneity: Effects of Oxygen on Metabolic Functions of Hepatocytes. Journal of Cellular Engineering, 1:125-135 (PDF)

Bhatia SN, Toner M, Tompkins RG, and Yarmush ML (1994): Selective Adhesion of Hepatocytes on Patterned Surfaces. Annals of New York Academy of Sciences 745:187-209

Rotem A, Toner M, Bhatia SN, Foy BD, Tompkins RG, and Yarmush ML (1994): Oxygen is a Factor Determining In Vitro Tissue Assembly: Effects on Attachment and Spreading of Hepatocytes. Biotechnology & Bioengineering 43:654-660 (PDF)