Cell and tissue engineering for liver disease.

Publication Type:

Journal Article


Sci Transl Med, Volume 6, Issue 245, p.245sr2 (2014)


Animals, Cell Engineering, Disease Models, Animal, Humans, Liver, Liver Diseases, Tissue Engineering, Translational Medical Research


<p>Despite the tremendous hurdles presented by the complexity of the liver&#39;s structure and function, advances in liver physiology, stem cell biology and reprogramming, and the engineering of tissues and devices are accelerating the development of cell-based therapies for treating liver disease and liver failure. This State of the Art Review discusses both the near- and long-term prospects for such cell-based therapies and the unique challenges for clinical translation.</p>