HeLiVa platform: integrated heart-liver-vascular systems for drug testing in human health and disease.

Publication Type:

Journal Article

Source:

Stem Cell Res Ther, Volume 4 Suppl 1, p.S8 (2013)

Keywords:

Antiviral Agents, Cell Differentiation, Electric Stimulation, Endothelial Cells, Hepatitis C, Hepatocytes, Humans, Induced Pluripotent Stem Cells, Microfluidic Analytical Techniques, Myocytes, Cardiac

Abstract:

Our project team is developing an integrated microphysiological platform with functionally connected vascular, liver and cardiac microtissues derived from a single line of human pluripotent stem cells. The platform enables functional representation of human physiology in conjunction with real-time biological readouts (via imaging and homologous reporters for all three cell phenotypes) and compatibility with high-throughput/high-content analysis. In this paper, we summarize progress made over the first year of the grant.

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