HeLiVa platform: integrated heart-liver-vascular systems for drug testing in human health and disease.

Publication Type:

Journal Article


Stem Cell Res Ther, Volume 4 Suppl 1, p.S8 (2013)


Antiviral Agents, Cell Differentiation, Electric Stimulation, Endothelial Cells, Hepatitis C, Hepatocytes, Humans, Induced Pluripotent Stem Cells, Microfluidic Analytical Techniques, Myocytes, Cardiac


Our project team is developing an integrated microphysiological platform with functionally connected vascular, liver and cardiac microtissues derived from a single line of human pluripotent stem cells. The platform enables functional representation of human physiology in conjunction with real-time biological readouts (via imaging and homologous reporters for all three cell phenotypes) and compatibility with high-throughput/high-content analysis. In this paper, we summarize progress made over the first year of the grant.