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News

Boston Globe: Her studies link engineering, biology

Technology Review: A Better Toxicity Test

MIT nanoEECS: Why small is beautiful in Electrical Engineering and Computer Science

Journal Publications

1. Park, J-H, von Maltzahn, G, Schwartz, MP, Ruoslahti, E, Bhatia, SN, Sailor, MJ (2008). Magnetic iron oxide nanoworms for tumor targeting and imaging. Advanced Materials, 20 (9): 1630-1635.

News article in Analytical Chemistry 'Analytical Currents' section: Improved superparamagnetic nanoparticles for targeting and imaging; Analytical Chemistry, July 1 2008, page 4777.


2. Higgins JM, Eddington DT, Bhatia S, Mahadevan L (2007). Sickle-cell vasoocclusion and rescue in a microfluidic device. PNAS, 104 (51): 20496-20500.


3. Khetani, SR, and Bhatia, SN (2007): Microscale human liver tissue for drug development. Nature Biotechnology, 26 (1): 120-126..


4. von Maltzahn, G [†], Min, D-H [†], Zhang, Y, Park, J-H, Harris, TJ,
   Sailor, M, Bhatia, SN (published online 16 Oct 2007): Nanoparticle
   self-assembly directed by antagonistic kinase and phosphatase activities.
   Advanced Materials, 19(21): 3579-3583. [†] These authors contributed equally


5. Hui, E. E. & Bhatia, SN (2007) Silicon microchips for manipulating cell-cell interaction. J. Visualized Exp.; 7 〈http://www.jove.com/index/Details.stp?ID=268〉.


6. Derfus, AM, von Maltzahn, G, Harris, TJ, Duza, T, Vecchio, KS, Ruoslahti, E,
   Bhatia, SN (2007). Remotely triggered release from magnetic nanoparticles.
   Advanced Materials, 19: 3932-3936.


7. Gregory H. Underhill and Bhatia, SN (availabale online 25 July 2007).High-throughput analysis of signals regulating stem cell fate and function. Current Opinion in Chemical Biology, 11: 357-366.


8. Flaim CJ, Teng D, Chien S, and Bhatia, SN (2008). Combinatorial signaling microenvironments for studying stem cell fate. Stem Cells and Development, 17: 1–11.
* For higher resolution version of the images in the pdf file, please click on the images in the document. A window with the high resolution images should open in your internet browser.


9. Dirk R. Albrecht, Gregory H. Underhill, Avital Mendelson and Sangeeta N. Bhatia (2007). Multiphase electropatterning of cells and biomaterials. Lab Chip, 7(6), pp 702 – 709.


10. Derfus, AM, Chen, AA, Min, D-H, Ruoslahti, E, Bhatia, SN (2007): Targeted quantum dot conjugates for siRNA delivery.Bioconjugate Chemistry, 18(5); 1391-1396.


11. Evans, AR, Euteneuer, S, Chavez, E., Mullen, LM, Hui, EE, Bhatia, SN, Ryan, AF (published online 28 June, 2007). Laminin and fibronectin modulate inner ear spiral ganglion neurite outgrowth in an in vitro alternate choice assay. Developmental Neurobiology, 67(13): 1721-1730.


12. von Maltzahn, G, Harris, TJ, Park, J-H, Min, DH, Schmidt, AJ, Sailor, MJ,
    and Bhatia, SN (2007) . Nanoparticle self-assembly gated by logical
    proteolytic triggers. Journal of the American Chemical Society,129(19) pp 6064 - 6065.

* Featured on NCI Cancer News

* Featured in Nature Nanotechnology Research Highlights


13. Hui, EE and Bhatia, SN (2007). Micromechanical control of
    cell-cell interactions. Proceedings of the National Academy of Sciences, 104, 5722-5726.
    
    * Featured on MIT website
    * Featured in Analytical Chemistry, Biosphere section, 'Deciphering Cellular Conversations'. Vol. 79, No. 11: June 1, 2007. p 3962.
    * Featured in Nature Methods, Research Highlights, 'A Gentle Touch for Cells'. Vol.4(6), June 2007, p. 472.'


14. Liu Tsang, V, Chen, AA, Cho, LM, Jadin, KD, Sah, RL, DeLong, S, West, JL, and Bhatia, SN (2007) Fabrication of 3D hepatic tissues by
    additive photopatterning of cellular hydrogels. FASEB J, 21:790-801.


15. Hui E, Bhatia SN, (2007) Microscale Control of Cell Contact and Spacing via Three-Component Surface Patterning. Langmuir, 23: 4103-4107.


16. Simberg D, Duza T, Park JH, Essler M, Pilch J, Zhang L, Derfus AM, Yang M, Hoffman RM, Bhatia SN, Sailor MJ, Ruoslahti E (2007). Biomimetic amplification of nanoparticle homing to tumors. Proceedings of the National Academy of Sciences, 104: 932-936.
    


17. Underhill GH*, Chen AA*, Albrecht DR, Bhatia SN (2007).  Assessment of hepatocellular function within PEG hydrogels.  Biomaterials, 28: 256-270. (*These authors contributed equally).


18. Allen JW, Khetani SR, Johnson RS, Bhatia SN. (2006) In Vitro Liver Tissue Model Established from Transgenic Mice: Role of HIF1alpha on Hypoxic Gene Expression.
    Tissue Eng. 12(11), 3135-3147.


19. Khetani SR, Bhatia SN. (2006) Engineering tissues for in vitro applications. Current Opinion in Biotechnology 17: 524-531.
    
    
20. Harris TJ*, von Maltzahn G*, Derfus AM, Rouslahti E, Bhatia SN. (2006) Proteolytic Actuation of Nanoparticle Self-Assembly. Angewandte Chemie International Edition 41 (19): 3161-3165.
    (*These authors contributed equally)
    
    This acticle featured on the cover of Angewandte Chemie, in Nanotoday, and in MIT News.
    
    
21. Park J-H, Derfus AM, Segal E, Vecchio KS, Bhatia SN, Sailor MJ (2006). Local heating of discrete droplets using magnetic porous silicon-based photonic crystals.  Journal of the American Chemical Society, 128(24): 7938-7946 .
    
    
22. Albrecht DR, Underhill GH, Wassermann TB, Sah RL, Bhatia SN. (2006) Probing the role of multicellular organization in 3D microenvironments. Nature Methods 3, 369-375.
    This article featured in Nature Research Highlights, MIT News, and as Access Science Image of the Week.
    
    
23. Schwartz MP, Derfus AM, Alvarez SD, Bhatia SN, and Sailor MJ (2006).  The smart petri dish: A nanostructured photonic crystal for real-time monitoring of living cells. Langmuir, 22: 7084-7090 .
    
    This article featured on the cover of Langmuir, in Technology Review, and in UCSD news.
    
    
    
24. Chen AA*, Derfus AM*, Khetani SR, Bhatia SN (2005). Quantum Dots to Monitor siRNA Delivery and Improve Gene Silencing. Nucleic Acids Research 33 (22):190 (*These authors contributed equally)
    
    This paper featured on the 'NAR Hot Papers' webpage.
    
    
25. Allen JW, Khetani SR, Bhatia SN. (2005) In Vitro Zonation and Toxicity in a Hepatocyte Bioreactor. Toxicological Sciences 84, 110–119
    
    
26.   Albrecht DR, Liu Tsang V, Sah RL, Bhatia SN (2005): Photo- and Electropatterning of Hydrogel-Encapsulated Living Cell Arrays. Lab on a Chip. 5, 111-118.
    
    
27. Flaim CJ, Chien, S, Bhatia SN. (2005) An Extracellular Matrix Microarray for Probing Cellular Differentiation. Nature Methods. 2(2): 119-125 .
    
    This article featured in paragraph in Nature Methods Table of Contents.
    
    
28.  Dorvee J, Derfus AM, Bhatia SN, Sailor MJ. (2004) Manipulation of Liquid Droplets using Amphiphilic, Magnetic 1-D Photonic Crystal Chaperones. Nature Materials. 3: 896 - 899 .
    This Article Featured in  Nature News and Views: Magnetic Chaperones for Droplets
    
    
29. Lin P, Chan W, Badylak S, Bhatia SN (2004): Assessing Liver-Derived Biomatrix for Hepatic Tissue Engineering. Tissue Engineering 10 (7/8): 1046-1053.
    
    
30.  Chin V Sanga S, Taupin P, Scheel J, Gage FG, Bhatia SN (2004): A Microfabricated Platform for Studying Stem Cell Fates. Biotechnology and Bioengineering. 88 (3): 399-415.
    
    
31. Allen JW, Johnson RS, and  Bhatia SN. (2005): Hypoxic inhibition of 3-methylcholanthrene-induced CYP1A1 expression is independent of HIF-1alpha . Toxicology Letters 155: 151–159.
    
    
32.  Albrecht D. Sah R, Bhatia SN (2004): Geometric and Material Determinants of Particle Kinetics and Patterning Efficiency by Dielectrophoresis. Biophysical Journal. 87 (4): 2131-2147.
    
    
33.  Liu Tsang VA and Bhatia SN (2004):  3-Dimensional Tissue Fabrication.  Advanced Drug Delivery Reviews. 56 :1635– 1647.
    
    
34.  Khetani S, Szulgit G, Del Rio J, Barlow C, Bhatia SN (2004): Exploring Interactions Between Hepatocytes and Nonparenchymal Cells Using Gene Expression Profiling. Hepatology.40(3): 545-54.
    
    
35.  Derfus AM, Chan WCW, Bhatia SN (2004): Intracellular Delivery of Quantum Dots for Live Cell Labeling and Organelle Tracking. Advanced Materials 16(12): 961-966.
    
    
36.  Derfus AM, Chan WCW, Bhatia SN (2004): Probing the Cytotoxicity of Semiconductor Quantum Dots. Nanoletters 4(1); 11-18
    
    
37. Li YY, Cunin F, Link JR, Gao T, Betts RE, Reiver SH, Chin V, Bhatia SN and Sailor MJ (2003): TPolymer Replicas of Photonic Porous Silicon For Sensing and Drug Delivery Applications. Science 299:, 2045-2047
    
    
38. Liu VA and Bhatia SN, (2002): Three-Dimensional Photopatterning of Hydrogels Containing Living Cells. Biomedical Microdevices 4:4, 257-266
    
    
39. Akerman ME*, Chan WCW*, Laakkonen P, Bhatia SN and Ruoslahti E (2002): Nanocrystal Targeting In Vivo. Proceedings of the National Academy of Sciences 99(20): 12617-12621 *These authors contributed equally.
    
    
40. Cunin F, Schmedake TA, Link JR, Koh, J, Bhatia SN and Sailor MJ (2002): Biomolecular screening with encoded porous silicon photonic crystals. Nature Materials 1(1): 39-41 (News & Views Article on this subject.)
    
    
41. Ozkan M, Pisanic T, Barlow C, Esener, S, Bhatia SN. (2003): An Integrated Electro-Optical Platform for the Manipulation of Live Cells. Langmuir 19:, 1532-1538
    
    
42. Allen J W, and Bhatia SN (2003) Formation of Steady-State Oxygen Gradients In vitro: Application to Liver Zonation. Biotechnology and Bioengineering 82: 253-262
    
    
43. Vozzi G, Flaim CJ, Ahluwalia A, and Bhatia SN (2003): Fabrication of PLGA Scaffolds Using Soft Lithography and Microsyringe Deposition. Biomaterials 24: 2533-2540
    
    
44. Gopalan SM, Flaim C, Bhatia SN, Hoshijima M, Knoel R, Chien KR, Omens JH, and McCulloch AD (2003): Anisotropic Stretch-induced Hypertrophy in Neonatal Ventricular Myocytes Micropatterned on Deformable Elastomers. Biotechnology & Bioengineering 81(5): 578-587
    
    
45. Allen J W, and Bhatia SN (2002) Improving the Next Generation of Bioartificial Liver Devices. Seminars in Cell and Developmental Biology 13(6): 447-454
    
    
46. Allen J, Hassenein T, and Bhatia SN (2002): Engineering Liver Therapies for the Future. Tissue Engineering, 8(5): 725-737
    
    
47. Ozkan M, Bhatia SN, and Esener, SC (2002): Optical Addressing of Polymer Beads in Microdevices. Sensors and Materials, 14(4): 189-97
    
    
48. Heyman GD, Bryn M, and Bhatia SN (2002): Gender and Achievement-Related Beliefs among Engineering Students: A Social-  Cognitive Perspective. The Journal of Women and Minorities in Science and Engineering 8 (1):41-52
    
    
49. Vozzi G, Flaim CJ, Ahluwalia A, Bianchi F, and Bhatia SN (2002): Microfabricated PLGA Scaffolds: A Comparative Study for Application to Tissue Engineering. Materials Science & Engineering C, 20(1-2):43-47
    
    
50. V.A. Liu, W.E. Jastromb, and S.N. Bhatia, (2002): Engineering protein and cell adhesivity using PEO-terminated triblock polymers. Journal of Biomedical Materials Research 60(1): 126-134
    
    
51. Ozkan, M., Ozkan, CS, Kibar, O, Wang MM, Bhatia SN, and Esener SC (2001): Heterogeneous Integration through Electrokinetic Migration. IEEE Journal of EMB Magazine, 20(6): 144-151
    
    
52. Ozkan M, Esener SC, and Bhatia, SN (2001): Electrokinetic Assembly of Microsphere and Cellular Arrays, Materials Research Society Joint Proceedings: Biomaterials for Drug Delivery and Tissue Engineering, 662 NN6.4
    
    
53. Bhatia SN (2001). Micropatterned Cultures and Co-Cultures. Methods of Tissue Engineering, (Eds.) Atala and Lanza, Harcourt Academic Press, Ch 8: 121-129
    
    
54. Chin V, Collins B, Sailor M, and Bhatia SN (2001): Compatibility of Primary Hepatocytes on Nanoporous Silicon. Advanced Materials 13(24): 1877-1880
    
    
55. Allen J, Hassenein T, and Bhatia SN (2001): Advances in Bioartificial Liver Devices. Hepatology 34(3): 447-455
    
    
56. Song L, Bhatia SN, Hu YL, Shiu YT, Li YS, Usami S, and Chien S (2001): Effects of Morphological Patterning on Endothelial Cell Migration. Biorheology 38: 101-108
    
    
57. Behnia K, Bhatia SN, Jastromb N, Balis U, Sullivan S, Yarmush M, and Toner M (2000): Xenobiotic Metabolism by Cultured Primary Porcine Hepatocytes. Tissue Engineering 6(5): 467-479
    
    
58. Bhatia SN, and Chen C (1999) Tissue Engineering at the Micro-Scale. Biomedical Microdevices 2(2): 131-144
    
    
59. Bhatia SN, Balis U, Yarmush ML, and Toner M (1999) Effect of Cell-Cell Interactions in Preservation of Cellular Phenotype: Co-Cultivation of Hepatocytes and Non-Parenchymal Cells. FASEB J 13(14): p. 1883-1900
    
    
60. Bhatia SN, Suri V, Budny A, and Krauss C (1999). Prenatal detection and mapping of a distal 8p deletion associated with congenital heart disease. Prenatal Diagnosis 19(9): 863-7
    
    
61. Balis UJ, Behnia K, Dwarkanath B, Bhatia SN, Sullivan SJ, Yarmush ML, and Toner M (1999) Oxygen Consumption Characteristics of Porcine Hepatocytes. Metabolic Engineering 1: 49-62
    
    
62. Ledezma GA , Folch A, Bhatia SN, Balis UJ, Yarmush ML, and Toner M (1999) Numerical Model of Fluid Flow and Oxygen Transport in a Radial-Flow Microchannel Containing Hepatocytes. Journal of Biomechanical Engineering 121: 58-64
    
    
63. Bhatia SN, Balis U, Yarmush ML, Toner M (1998) Probing Heterotypic Cell Interactions: Hepatocyte Function in Microfabricated Co-Cultures. J Biomaterials Science, Polymer Edition 9(11): 1137-1160
    
    
64. Bhatia SN, Balis U, Yarmush ML, Toner M (1998) Microfabrication of Hepatocyte/Fibroblast Co-Cultures: Role of Homotypic Cell Interactions. Biotechnology Progress 14: 378-387
    
    
65. Bhatia SN, Yarmush ML, Toner M (1997) Engineered Substrates for Controlling Cell-Cell Interactions. 1997 Advances in Heat and Mass Transfer in Biotechnology ASME HTD-355, BED- 37: 99-103
    
    
66. Bhatia SN, Yarmush ML, Toner M (1997) Controlling Cell Interactions by Micropatterning in Co-Cultures: Hepatocytes and 3T3 Fibroblasts. Journal of Biomedical Materials Research, 34 (2): 189-199
    
    
67. Bhatia SN, Toner M, Foy BD, Rotem A, O'Neil KM, Tompkins RG, Yarmush ML (1996) Zonal Liver Cell Heterogeneity: Effects of Oxygen on Metabolic Functions of Hepatocytes. Journal of Cellular Engineering, 1:125-135
    
    
68. Bhatia SN, Toner M, Tompkins RG, Yarmush ML (1994) Selective Adhesion of Hepatocytes on Patterned Surfaces. Annals of New York Academy of Sciences 745:187-209
    
    
69. Rotem A, Toner M, Bhatia SN, Foy BD, Tompkins RG, Yarmush ML (1994) Oxygen is a Factor Determining In Vitro Tissue Assembly: Effects on Attachment and Spreading of Hepatocytes. Biotechnology & Bioengineering 43:654-660
    

Book Chapters

Underhill GH, Khetani SR, Chen AA, Bhatia SN. (2007), Liver Tissue Engineering, in Principles of Tissue Engineering, Third Edition. R. Lanza, R. Langer, J.P. Vacanti (eds.), Elsevier, p. 707-732.

Liu WF, Hui EE, Bhatia SN, Chen CS (2007, in press). Engineering Cellular Microenvironments. In Principles of Regenerative Medicine, Atala, A, Lanza, R, Thomson, JA, Nerem, RM (eds.), Elsevier.

Harris, TJ, von Maltzahn, G, and Bhatia SN (2006). Multifunctional Nanoparticles for Cancer Therapy, in Nanotechnology for Cancer Therapy.  M.M. Amiji (ed.), Taylor and Francis/CRC Press.

Underhill GH, Felix J, Allen JW, Tsang VL, Khetani SR, Bhatia SN. (2006), Tissue Engineering of the Liver.  Culture of Cells for Tissue Engineering . G. Vunjak-Novakovic, R.I. Freshney (eds.), John Wiley and Sons.

Chen, A, Liu Tsang, V, Albrecht, D and Bhatia, SN (2006) 3-D fabrication technology for tissue engineering, in BioMEMS and Biomedical Nanotechnology (M. Ferrarik, ed), Volume III: Therapeutic Micro/Nano Technology (T. Desai and S. Bhatia, eds), Springer, NY, p. 23-38.

Liu Tsang, V. and Bhatia, S.N. (2006): Fabrication of three-dimensional tissues, in Advances in Biochemical Engineering/Biotechnology. Special vol.: Tissue Engineering II: Basics of Tissue Engineering and Tissue Applications, K. Lee, D. Kaplan eds. Springer Berlin / Heidelberg, p. 189-205.

Hassanein T., Stange J, Bhatia SN, and Mehta R (2007): Artificial Liver and Blood Cleansing Techniques, in TRAUMA: Critical Care Volume 2. WC Wilson, CM Grande, DB Hoyt (eds.), Informa Healthcare

Bhatia SN and Toner M (1998) Micropatterning Cells in Tissue Engineering. Methods in Molecular Medicine, Vol 18: Tissue Engineering Methods and Protocols (Eds). J Morgan and M.L. Yarmush, Humana Press, NJ: 349-363

Books

Bhatia, SN & Desai, T, eds. (2006) Volume III Therapeutic Micro/Nano
Technology. BioMEMS and Biomedical Micro/Nano Technology (M. Ferrari, ed),
Springer, NY.

Palsson, B and Bhatia, SN (2003) Tissue Engineering Prentice Hall, NY, NY

Bhatia, SN. (1999) Microfabrication in Tissue Engineering and Bioartificial Organs (Ed.) Stephen Senturia, Kluwer Academic Press, MA