Cell and tissue engineering for liver disease.

Publication Type:

Journal Article

Source:

Sci Transl Med, Volume 6, Issue 245, p.245sr2 (2014)

Keywords:

Animals, Cell Engineering, Disease Models, Animal, Humans, Liver, Liver Diseases, Tissue Engineering, Translational Medical Research

Abstract:

Despite the tremendous hurdles presented by the complexity of the liver's structure and function, advances in liver physiology, stem cell biology and reprogramming, and the engineering of tissues and devices are accelerating the development of cell-based therapies for treating liver disease and liver failure. This State of the Art Review discusses both the near- and long-term prospects for such cell-based therapies and the unique challenges for clinical translation.