HeLiVa platform: integrated heart-liver-vascular systems for drug testing in human health and disease

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Publication Type:

Journal Article

Authors:

Vunjak-Novakovic‡, Gordana; Sangeeta N Bhatia; Chen, Christopher; Hirschi, Karen

Source:

Stem Cell Res Ther, Volume 4 Suppl 1, p.S8 (2013)

Abstract:

Our project team is developing an integrated microphysiological platform with functionally connected vascular, liver and cardiac microtissues derived from a single line of human pluripotent stem cells. The platform enables functional representation of human physiology in conjunction with real-time biological readouts (via imaging and homologous reporters for all three cell phenotypes) and compatibility with high-throughput/high-content analysis. In this paper, we summarize progress made over the first year of the grant.

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