Publications

2024

Featured

RNA delivery systems

Bhatia SN, Dahlman JE.

PNAS (2024)

Manuscript (PDF)

Autonomous circadian rhythms in the human hepatocyte regulate hepatic drug metabolism and inflammatory responses

Sandra March, Niketa Nerurkar, Anisha Jain, Linda Andrus, Daniel Kim, Charles A. Whittaker, Edward K.W. Tan, Sabine Thiberge, Heather E. Fleming, Liliana Mancio-Silva, Charles M. Rice, and Sangeeta N. Bhatia.

Science Advances (2024)

Manuscript: (PDF)

Supplementary Materials (PDF)

News coverage:

MIT News Feature (here), AAAS Feature (here).

Targeting and monitoring ovarian cancer invasion with an RNAi and peptide delivery system

Liangliang Hao, Natalie Boehnke, Susanna K. Elledge, Nour-Saïda Harzallah, Renee T. Zhao, Eva Cai, Yu-XiongFeng, Sofia Neaher, Heather E. Fleming, Piyush B. Gupta, Paula T. Hammond, and Sangeeta N. Bhatia.

PNAS (2024)

Manuscript: (PDF)

Priming agents transiently reduce the clearance of cell-free DNA to improve liquid biopsies

Carmen Martin-Alonso, Shervin Tabrizi , Kan Xiong, Timothy Blewett, Sainetra Sridhar, Andjela Crnjac, Sahil Patel, Zhenyi An, Ahmet Bekdemir, Douglas Shea, Shih-Ting Wang, Sergio Rodriguez-Aponte, Christopher A. Naranjo, Justin Rhoades, Jesse D. Kirkpatrick, Heather E. Fleming, Ava P. Amini, Todd R. Golub, J. Christopher Love , Sangeeta N. Bhatia, and Viktor A. Adalsteinsson.

Science (2024)

Manuscript (PDF)

Cited by:

Tina Moser, Ellen Heitzer, Surpassing sensitivity limits in liquid biopsy. Science383,260-261 (2024). (PDF).

Sarah Crunkhorn, Improving liquid biopsy for cancer detection. Nature Reviews Drug Discovery (2024). (PDF).

News coverage:

MIT News Feature (here), Broad Press Release (here).

Inhalable point-of-care urinary diagnostic platform

Qian Zhong, Edward K. W. Tan, Carmen Martin-Alonso, Tiziana Parisi, Liangliang Hao, Jesse D. Kirkpatrick, Tarek Fadel, Heather E. Fleming, Tyler Jacks, Sangeeta N. Bhatia.

Science Advances (2024)

Manuscript (PDF)

News coverage: MIT News Feature (here), HHMI Feature (here).

2023

Featured

CRISPR-Cas-mediated Multianalyte Synthetic Urine Biomarker Test for Portable Diagnostics

Van Heest AE, Deng F, Zhao RT, Harzallah NS, Fleming HE, Bhatia SN, Hao L.

JoVE (2023)

Manuscript (PDF)

Enhancing the immunogenicity of lipid-nanoparticle mRNA vaccines by adjuvanting the ionizable lipid and the mRNA

Li B, Jiang AY, Raji I, Atyeo C, Raimondo TM, Gordon AGR, Rhym LH, Samad T, MacIsaac C, Witten J, Mughal H, Chicz TM, Xu Y, McNamara RP, Bhatia S, Alter G, Langer R, Anderson DG.

Nature Biomedical Engineering (2023)

Manuscript (PDF)

CRISPR-Cas-amplified urinary biomarkers for multiplexed and portable cancer diagnostics

Liangliang Hao, Renee T. Zhao, Nicole L. Welch, Edward Kah Wei Tan, Qian Zhong, Nour Saida Harzallah, Chayanon Ngambenjawong, Henry Ko, Heather E. Fleming, Pardis C. Sabeti & Sangeeta N. Bhatia

Nature Nanotechnology (2023)

Manuscript (PDF)

Profile of Sangeeta Bhatia

Julia Sklar

PNAS (2023)

Article (PDF)

Low protease activity in B cell follicles promotes retention of intact antigens after immunization

Aereas Aung, Ang Cui, Laura Maiorino, Ava P. Amini, Justin R. Gregory, Maurice Bukenya, Yiming Zhang, Heya Lee, Christopher A. Cottrell, Duncan M. Morgan, Murillo Silva, Heikyung Suh, Jesse D. Kirkpatrick, Parastoo Amlashi, Tanaka Remba, Leah M. Froehle, Shuhao Xiao, Wuhbet Abraham, Josetta Adams, J. Christopher Love, Phillip Huyett, Douglas S. Kwon, Nir Hacohen, William R. Schief, Sangeeta N. Bhatia, Darrell J. Irvine

Science (2023)

Manuscript (PDF)

2022

Featured

Cancer nanomedicine

Sangeeta N. Bhatia , Xiaoyuan Chen , Marina A. Dobrovolskaia and Twan Lammers

Nature Cancer Reviews (2022)

Manuscript (PDF)

Multiscale profiling of protease activity in cancer

Ava P. Amini, Jesse D. Kirkpatrick, Cathy S. Wang, Alex M. Jaeger, Susan Su, Santiago Naranjo, Qian Zhong, Christina M. Cabana, Tyler Jacks & Sangeeta N. Bhatia

Nature Communications (2022)

Manuscript (PDF)
Supporting information (PDF)

Ebola virus infection induces a delayed type I IFN response in bystander cells and the shutdown of key liver genes in human iPSC-derived hepatocytes

Whitney A. Scoon, Liliana Mancio-Silva, Ellen L. Suder, Carlos Villacorta-Martin, Jonathan Lindstrom-Vautrin, John G. Bernbaum, Steve Mazur, Reed F. Johnson, Judith Olejnik, Elizabeth Y. Flores, Aditya Mithal, Feiya Wang, Adam J. Hume, Joseph E. Kaserman, Sandra March-Riera, Andrew A. Wilson, Sangeeta N. Bhatia, Elke Mühlberger, Gustavo Mostoslavsky

Cell Reports (2022)

Manuscript (PDF)
Supporting information (PDF)

Conditional Antimicrobial Peptide Therapeutics

Chayanon Ngambenjawong, Leslie W. Chan, Heather E. Fleming, and Sangeeta N. Bhatia

ACS Nano (2022)

Manuscript (PDF)
Supporting information (PDF)

Direct capture of neutralized RBD enables rapid point-of-care assessment of SARS-CoV-2 neutralizing antibody titer

Guinevere G. Connelly, Orville O. Kirkland, Seven Bohannon, Daniel C. Lim, Robert M. Wilson, Edward J. Richards, Dousabel M. Tay, Hyuk Jee, Riley D. Hellinger, Ngoc K. Hoang, Liang Hao, Arnav Chhabra, Carmen Martin-Alonso, Edward K.W. Tan, Angela N. Koehler, Michael B. Yaffe, Wendy B. London, Pui Y. Lee, Florian Krammer, Robert C. Bohannon, Sangeeta N. Bhatia, Hadley D. Sikes, Hojun Li
Cell Reports Methods (2022)

Manuscript (PDF)
Supporting information (Link)

Protease Activity Analysis: A Toolkit for Analyzing Enzyme Activity Data

Ava P. Soleimany, Carmen Martin-Alonso, Melodi Anahtar, Cathy S. Wang, and Sangeeta N. Bhatia
ACS (2022)

Manuscript (PDF)
Supporting information (PDF)

A vascularized model of the human liver mimics regenerative responses

Arnav Chhabra, H.-H. Greco Song, Katarzyna A. Grzelak, William J. Polacheck, Heather E. Fleming, Christopher S. Chen, and Sangeeta N. Bhatia
PNAS (2022)

Manuscript (PDF)
Supporting information (PDF)

Host protease activity classifies pneumonia etiology

Melodi Anahtar, Leslie W. Chan, Henry Ko, Aditya Rao, Ava P. Soleimany, Purvesh Khatri, and Sangeeta N. Bhatia
PNAS (2022)

Manuscript (PDF)
Supporting information (PDF)

A single-cell liver atlas of Plasmodium vivax infection

Liliana Mancio-Silva, Nil Gural, Eliana Real, Marc H. Wadsworth II, Vincent L. Butty, Sandra March, Niketa Nerurkar, Travis K. Hughes, Wanlapa Roobsoong, Heather E. Fleming, Charlie A. Whittaker, Stuart S. Levine, Jetsumon Sattabongkot, Alex K. Shalek, and Sangeeta N. Bhatia
Cell Host & Microbe (2022)

Manuscript (PDF)
Supporting information (PDF)

Early detection of cancer

David Crosby, Sangeeta Bhatia, Kevin M. Brindle, Lisa M. Coussens, Caroline Dive, Mark Emberton, Sadik Esener, Rebecca C. Fitzgerald, Sanjiv S. Gambhir†, Peter Kuhn, Timothy R. Rebbeck, Shankar Balasubramanian
Science (2022)

Manuscript (PDF)

Ionic Liquid-Mediated Transdermal Delivery ofThrombosis-Detecting Nanosensors

Ahmet Bekdemir, Eden E. L. Tanner, Jesse Kirkpatrick, Ava P. Soleimany, Samir Mitragotri, and Sangeeta N. Bhatia
Advanced Healthcare Materials (2022)

Manuscript (PDF)
Supporting information (PDF)

Distinct Hepatic Gene-Expression Patterns of NAFLD in Patients With Obesity

Sonu Subudhi, Hannah K. Drescher, Laura E. Dichtel, Lea M. Bartsch, Raymond T. Chung, Matthew M. Hutter, Denise W. Gee, Ozanan R. Meireles, Elan R. Witkowski, Louis Gelrud, Ricard Masia, Stephanie A. Osganian, Jenna L. Gustafson, Steve Rwema, Miriam A. Bredella, Sangeeta N. Bhatia, Andrew Warren, Karen K. Miller, Georg M. Lauer, Kathleen E. Corey
Hepatology Communications (2022)

Manuscript (PDF)
Supporting information (Excel)

2021

Featured

Directing Cholangiocyte Morphogenesis in Natural Biomaterial Scaffolds

Q. Smith, J. Bays, L. Li, H. Shareef, C. S. Chen, and S. N. Bhatia
Advanced Science (2021)

Manuscript (PDF)
Supporting information (PDF)

Peptide-based urinary monitoring of fibrotic nonalcoholic steatohepatitis by mass-barcoded activity-based sensors

S. C. Cazanave, A. D. Warren , M. Pacula , F. Touti , A. Zagorska, N. Gural, E. K. Huang , S. Sherman, M. Cheema , S. Ibarra , J. Bates, A. N. Billin, J. T. Liles, G. R. Budas, D. G. Breckenridge , D. Tiniakos, V. Ratziu, A. K. Daly, O. Govaere , Q. M. Anstee, L. Gelrud, J. Luther, R. T. Chung, K. E. Corey , W. Winckler, S. Bhatia, G A. Kwong
Science Translational Medicine (2021)

Manuscript (PDF )
Supporting information (PDF)

Protease activity sensors enable real-time treatment response monitoring in lymphangioleiomyomatosis

J. D. Kirkpatrick, A. P. Soleimany, J. S. Dudani, H-J Liu, H. C. Lam, C. Priolo, E. P. Henske, S. N. Bhatia
European Respiratory Journal (2021)

Manuscript (PDF)

Synthetic biomarkers: a twenty-first century path to early cancer detection

G. A. Kwong, S. Ghosh, L. Gamboa, C. Patriotis, S. Srivastava and S. N. Bhatia
Nature Reviews Cancer (2021)

Manuscript (PDF)

Identification of NQO2 As a Protein Target in Small Molecule Modulation of Hepatocellular Function

A.G. Schepers, J. Shan, A. G. Cox, A. Huang, H. Evans, C. Walesky, H. E. Fleming, W. Goessling, and S. N. Bhatia
ACS Chemical Biology (2021)

Manuscript (PDF)

Synthetic Circuit-Driven Expression of Heterologous Enzymes for Disease Detection

J. He, L. Nissim, A. P. Soleimany, A. Binder-Nissim, H. E. Fleming, T. K. Lu, S. N. Bhatia
ACS Synthetic Biology (2021)

Manuscript (PDF)

Evidential Deep Learning for Guided Molecular Property Prediction and Discovery

A.P. Soleimany, A. Amini, S. Goldman, D. Rus, S.N. Bhatia, and C.W. Coley
ACS Central Science (2021)

Manuscript (PDF)

Supporting Information (PDF)

Microenvironment-triggered multimodal precision diagnostics

L. Hao, N. Rohani, R. T. Zhao, E. M. Pulver, H. Mak, O. J. Kelada, H. Ko, H. E. Fleming, F. B. Gertler, S. N. Bhatia
Nature Materials (2021)

Manuscript (PDF), MIT News feature (Link)

Two chemoattenuated PfSPZ malaria vaccines induce sterile hepatic immunity

A. Mwakingwe-Omari, S. A. Healy, J. Lane, D. M. Cook, S. Kalhori, C. Wyatt, A. Kolluri, O. Marte-Salcedo, A. Imeru, M. Nason, L. K. Ding, H. Decederfelt, J. Duan, J. Neal, J. Raiten, G. Lee, J. C. C. Hume, J. E. Jeon, I. Ikpeama, N. Kc, S. Chakravarty, T. Murshedkar, L. W. P. Church, A. Manoj, A. Gunasekera, C. Anderson, S. C. Murphy, S. March, S. N. Bhatia, E. R. James, P. F. Billingsley, B. K. L. Sim, T. L. Richie, I. Zaidi, S. L. Hoffman, P. E. Duffy
Nature (2021)

Manuscript (PDF), Nature News and Views feature (Link), Nature News feature (Link)

Opening the path to biotech

S.N. Bhatia, N. Hopkins, S. Hockfield
Science (2021)

Manuscript (PDF)

Selective Permeabilization of Gram-Negative Bacterial Membranes Using Multivalent Peptide Constructs for Antibiotic Sensitization

L. W. Chan, K. E. Hern, C. Ngambenjawong, K. Lee, E. J. Kwon, D. T. Hung, S. N. Bhatia
ACS Infectious Diseases (2021)

Manuscript (PDF), Supporting Information (PDF)

Fusogenic porous silicon nanoparticles as a broad-spectrum immunotherapy against bacterial infections

B. Kim, Q. Yang, L. W. Chan, S. N. Bhatia, E. Ruoslahti, M. J. Sailor
Nanoscale Horiz. (2021)

Manuscript (PDF), Supporting information (PDF)

Virtual Undergraduate Research Experiences: More Than a Pandemic Stopgap

T. Samad, H.E. Fleming, S.N. Bhatia
Med (2021)

Manuscript (PDF)

Activatable zymography probes enable in situ localization of protease dysregulation in cancer

A.P. Soleimany, J.D. Kirkpatrick, S. Su, J.S. Dudani, Q. Zhong, A. Bekdemir and S. N. Bhatia
Cancer Research (2021)

Manuscript (PDF), Supporting information (link)

2020

Featured

Transient Support from Fibroblasts is Sufficient to Drive Functional Vascularization in Engineered Tissues

H.-H. G. Song, A. Lammers, S. Sundaram, L. Rubio, A. X. Chen, L. Li, J. Adv. Funct. Mat. (2020)

Manuscript (PDF)

Peptide Spiders: Peptide–Polymer Conjugates to Traffic Nucleic Acids

E. J. Kwon, H. Ko, S.N. Bhatia
Mol. Pharm. (2020)

Manuscript (PDF), Supporting Information (PDF)

Mapping functional humoral correlates of protection against malaria challenge following RTS,S/AS01 vaccination

Suscovich, T. J., Fallon, J. K., Das, J., Demas, A. R., Crain, J., Linde, C. H., Michell, A., Natarajan, H., Arevalo, C., Broge, T., Linnekin, T., Kulkarni, V., Lu, R., Slein, M. D., Luedemann, C., Marquette, M., March, S., Weiner, J., Gregory, S., Coccia, M., Flores-Garcia, Y., Zavala, F., Ackerman, M. E., Bergmann-Leitner, E., Hendriks, J., Sadoff, J., Dutta, S., Bhatia, S. N., Lauffenburger, D. A., Jongert, E., Wille-Reece, U. & Alter, G.
Sci. Transl. Med. 12, (2020).

Manuscript (PDF), Supporting Information (PDF)

Controlled apoptosis of stromal cells to engineer human microlivers

A.X. Chen, A. Chhabra, H.-H. G.Song, H.E. Fleming, C.S. Chen, and S.N. Bhatia
Advanced Functional Materials (2020)

Manuscript (PDF), Supporting Information (PDF)

Nanoparticle delivery of immunostimulatory oligonucleotides enhances response to checkpoint inhibitor therapeutics

C. G. Buss and S. N. Bhatia
Proceedings of the National Academy of Sciences (2020)

Manuscript (PDF), Supporting Information (PDF)

Pharmacokinetic tuning of protein–antigen fusions enhances the immunogenicity of T-cell vaccines

N. K. Mehta, Pradhan, R. V., Soleimany, A. P., Moynihan, K. D., Rothschilds, A. M., Momin, N., Rakhra, K., Mata-Fink, J., Bhatia, S. N., K. Wittrup, D., and Irvine, D. J.
Nature Biomedical Engineering. (2020)

Manuscript (PDF), Supporting Information (PDF)

Cancer Cell–Derived Matrisome Proteins Promote Metastasis in Pancreatic Ductal Adenocarcinoma

C. Tian, hlund, D. Ö., Rickelt, S., m, Tö, Huang, Y., Hao, L., Zhao, R. T., Franklin, O., Bhatia, S. N., Tuveson, D. A., and Hynes, R. O.
Cancer Research, vol. 80, no. 7, pp. 1461 - 1474 (2020)

Manuscript (PDF)

Activity-Based Diagnostics: An emerging paradigm for disease detection and monitoring

A.P. Soleimany and S.N. Bhatia
Trends in Molecular Medicine (2020)

Manuscript (PDF)

Urinary detection of lung cancer in mice via noninvasive pulmonary protease profiling

J. D. Kirkpatrick, A. D. Warren, A. P. Soleimany, P. M. K. Westcott, J. C. Voog, C. Martin-Alonso, H. E. Fleming, T. Tammela, T. Jacks, and S. N. Bhatia
Science Translational Medicine (2020)

Manuscript (PDF), Supporting information (PDF)

Genetic Encoding of Targeted Magnetic Resonance Imaging Contrast Agents for Tumor Imaging

S. Schuerle, M. Furubayashi, A. P. Soleimany, T. Gwisai, W. Huang, C. Voigt, and S. N. Bhatia
ACS Synth. Biol. 9, 392–401 (2020).

Manuscript (PDF), Supporting information (PDF)

Expansion, in vivo–ex vivo cycling, and genetic manipulation of primary human hepatocytes

E. Michailidis, K. Vercauteren, L. Mancio-Silva, L. Andrus, C. Jahan, I. Ricardo-Lax, C. Zou, M. Kabbani, P. Park, C. Quirk, C. Pyrgaki, B. Razooky, L. Verhoye, I. Zoluthkin, W. Lu, S.J. Forbes, L. Chiriboga, N.D. Theise, R.W. Herzog, H. Suemizu, W.M. Schneider, A. Shlomai, P. Meuleman, S.N. Bhatia, C.M. Rice, Y.P. de Jong.
Proc Natl Acad Sci USA 117, 1678–1688 (2020)

Manuscript (PDF), Supplementary Information (PDF)

QnAs with Sangeeta N. Bhatia

P. Nair.

PNAS, p. 201922176 (2020)

Article (PDF)

Engineering synthetic breath biomarkers for respiratory disease

L.W. Chan, M.N. Anahtar, T.-H. Ong, K.E. Hern, R.R. Kunz, and S.N. Bhatia
Nature Nanotechnology (2020)

Manuscript (PDF), Supporting Information (PDF)

2019

Featured

Targeting Liver Stage Malaria With Metformin

Vera, I. M., Grilo Ruivo, M. T., Lemos Rocha, L. F., Marques, S., Bhatia, S. N., Mota, M. M. & Mancio-Silva, L.
JCI Insight 4, (2019)

Manuscript (PDF)

Theranostic Layer-by-Layer Nanoparticles for Simultaneous Tumor Detection and Gene Silencing.

N. Boehnke, S. Correa, L. Hao, W. Wang, J. P. Straehla, S. N. Bhatia, P. T. Hammond.
Angew Chem Int Ed Engl. 59, 2776–2783 (2020).

Manuscript (PDF), Supporting information (PDF)

Non-viral delivery of CRISPR/Cas9 complex using CRISPR-GPS nanocomplexes

P. K. Jain, J. H. Lo, S. Rananaware, M. Downing, A. Panda, M. Tai, S. Raghavan, H. E. Fleming, S. N. Bhatia.
Nanoscale. 11, 21317–21323 (2019).

Manuscript (PDF), Supporting information (PDF)

Tumor penetrating nanomedicine targeting both an oncomiR and an oncogene in pancreatic cancer

M.-E. Gilles, L. Hao, K. Brown, J. Lim, S. N. Bhatia, F. J. Slack
Oncotarget. 10, 5349–5358 (2019).

Manuscript (PDF), Supporting information (PDF)

Renal clearable catalytic gold nanoclusters for in vivo disease monitoring

C. N. Loynachan †, A. P. Soleimany †, J. S. Dudani, Y. Lin, A. Najer, A. Bekdemir, Q. Chen, S. N. Bhatia, and M. M. Stevens
Nat. Nanotechnol. 14, 883–890 (2019).

Manuscript (PDF), Supporting information (PDF)

Antimalarial Activity of Primaquine Operates via a Two-Step Biochemical Relay

Camarda, G., Jirawatcharadech, P., Priestley, R. S., Saif, A., March, S., Wong, M. H. L., Leung, S., Miller, A. B., Baker, D. A., Alano, P., Paine, M. J. I., Bhatia, S. N., O’Neill, P. M., Ward, S. A. & Biagini, G. A.
Nat. Commun. 10, 3226 (2019)

Manuscript (PDF), Supporting Information (PDF)

Synthetic and living micropropellers for convection-enhanced nanoparticle transport

Schuerle, S., Soleimany, A. P., Yeh, T., Anand, G. M., Häberli, M., Fleming, H. E., Mirkhani, N., Qiu, F., Hauert, S., Wang, X., Nelson, B. J. & Bhatia, S. N.
Sci. Adv. 5, eaav4803 (2019).

Manuscript (PDF), Supporting information (PDF)

Steroid Hormone Function Controls Non-competitive Plasmodium Development in Anopheles

Werling, K., Shaw, W. R., Itoe, M. A., Westervelt, K. A., Marcenac, P., Paton, D. G., Peng, D., Singh, N., Smidler, A. L., South, A., Deik, A. A., Mancio-Silva, L., Demas, A. R., March, S., Calvo, E., Bhatia, S. N., Clish, C. B. & Catteruccia, F.
Cell. 177, 315-325.e14 (2019).

Manuscript (PDF), Supporting information (PDF)

Improving drug discovery by nucleic acid delivery in engineered human microlivers

L. Mancio-Silva, H. E. Fleming, A. B. Miller, S. Milstein, A. Liebow, P. Haslett, L. Sepp-Lorenzino, and S. N. Bhatia.
Cell Metabolism (2019)

Manuscript (PDF), Supporting information (PDF)

Acidification of tumor at stromal boundaries drives transcriptome alterations associated with aggressive phenotypes

Rohani, N., Hao, L., Alexis, M. S., Joughin, B. A., Krismer, K., Moufarrej, M. N., Soltis, A. R., Lauffenburger, D. A., Yaffe, M. B., Burge, C. B., Bhatia, S. N. & Gertler, F. B.
Cancer Res. 79, 1952–1966 (2019).

Manuscript (PDF), Supporting information (PDF)

Uncovering and Mitigating Algorithmic Bias through Learned Latent Structure

A. Amini†, Soleimany, A. †, Schwarting, W., Bhatia, S. N., and Rus, D.
AAAI/ACM Conference on Artificial Intelligence, Ethics, and Society, 2019

Manuscript (PDF)

Estrogen Activation of G protein-coupled Estrogen Receptor 1 Regulates Phosphoinositide 3-kinase and mTOR Signaling to Promote Liver Growth in Zebrafish and Proliferation of Human Hepatocytes

S. Chaturantabut, Shwartz, A., Evason, K. J., Cox, A. G., Labella, K., Schepers, A. G., Yang, S., Aravena, M., Houvras, iv, Y., Mancio-Silva, L., Romano, S., Gorelick, D. A., Cohen, D. E., Zon, L. I., Bhatia, S. N., North, T. E., and Goessling, W.
Gastroenterology, 2019

Manuscript (PDF)

2018

Featured

Protease activity sensors noninvasively classify bacterial infections and antibiotic responses

C. Buss †, J.S. Dudani †, R. Akana, H.E. Fleming, and S.N. Bhatia
EBioMedicine (2018)

Manuscript (PDF), Supporting information (PDF)

Harnessing Protease Activity to Improve Cancer Care

J.S. Dudani, A.D. Warren, S.N. Bhatia.
Annu. Rev. Cancer Biol. 2, (2018).

Manuscript (PDF)

A Plasmodium berghei sporozoite-based vaccination platform against human malaria

A. M. Mendes, Machado, M., alves-Rosa, Nç, Reuling, I. J., Foquet, L., Marques, áudia, Salman, A. M., Yang, A. S. P., Moser, K. A., Dwivedi, A., Hermsen, C. C., nez-Díaz, éné, Viera, S., Santos, J. M., Albuquerque, ês, Bhatia, S. N., Bial, J., Angulo-Barturen, ñigo, Silva, J. C., Leroux-Roels, G., Janse, C. J., Khan, S. M., Mota, M. M., Sauerwein, R. W., and Prudêncio, M.
npj Vaccines, vol. 3, 2018.

Manuscript (PDF), Supporting information (PDF)

iRGD-guided tumor-penetrating nanocomplexes for therapeutic siRNA delivery to pancreatic cancer

J. H. Lo†, Hao, L. †, Muzumdar, M. D., Raghavan, S., Kwon, E. J., Pulver, E. M., Hsu, F., Aguirre, A. J., Wolpin, B. M., Fuchs, C. S., Hahn, W. C., Jacks, T., and Bhatia, S. N.
Molecular Cancer Therapeutics, vol. 17, no. 11, pp. 2377-2388, 2018.

Manuscript (PDF), Supporting information (PDF)

Classification of prostate cancer using a protease activity nanosensor library

J. S. Dudani, Ibrahim, M., Kirkpatrick, J., Warren, A. D., and Bhatia, S. N.
Proc Natl Acad Sci U S A, vol. 115, no. 36, pp. 8954-8959, 2018.

Manuscript (PDF), Supporting information (PDF)

Genome-scale analysis identifies paralog lethality as a vulnerability of chromosome 1p loss in cancer

S. R. Viswanathan, Nogueira, M. F., Buss, C. G., Krill-Burger, J. M., Wawer, M. J., Malolepsza, E., Berger, A. C., Choi, P. S., Shih, J., Taylor, A. M., Tanenbaum, B., Pedamallu, C. Sekhar, Cherniack, A. D., Tamayo, P., Strathdee, C. A., Lage, K., Carr, S. A., Schenone, M., Bhatia, S. N., Vazquez, F., Tsherniak, A., Hahn, W. C., and Meyerson, M.
Nature Genetics, vol. 50, no. 7, pp. 937 - 943, 2018.

Manuscript (PDF), Supporting information (PDF)

A human monoclonal antibody prevents malaria infection by targeting a new site of vulnerability on the parasite

Kisalu, N.K., Idris, A.H., Weidle, C., Flores-Garcia, Y., Flynn, B.J., Sack, B.K., Murphy, Schön A., Freire, E., Francica, J.R., Miller, A.B., Gregory, J., March, S., Liao, H.X., Haynes, B.F., Wiehe, K., Trama, A.M., Saunders, K.O., Gladden, M.A., Monroe, A., Bonsignori, M., Kanekiyo, M., Wheatley, A.K., McDermott, A.B., Farney, S.K., Chuang, G.Y., Zhang, B., Kc, N., Chakravarty, S., Kwong, P.D., Sinnis, P., Bhatia, S.N., Kappe, S.H.I., Sim, B.K.L., Hoffman, S.L., Zavala, F., Pancera, M., and Seder, R.A.
Nature Medicine (2018)

Manuscript (PDF), Supporting information (PDF)

In vitro culture, drug sensitivity, and transcriptome of plasmodium vivax hypnozoites

N. Gural, L. Mancio-Silva, A.B. Miller, A. Galstian, V.L. Butty, S.S. Levine, R. Patrapuvich, S.P. Desai, S.A. Mikolajczak, S.H.I. Kappe, H.E. Fleming, S. March, J. Sattabongkot, and S.N. Bhatia
Cell Host & Microbe (2018)

Manuscript (PDF), Supporting information (PDF)

Personalized RNA-medicine for pancreatic cancer

M. - E. Gilles, Hao, L., Huang, L., Rupaimoole, R., Lopez-Casas, P. P., Pulver, E., Jeong, J. Cheol, Muthuswamy, S. K., Hidalgo, M., Bhatia, S. N., and Slack, F. J.
Clinical Cancer Research, vol. 24, no. 7, pp. 1734-1747, 2018.

Manuscript (PDF)

Engineered Livers for Infectious Diseases

N. Gural, Mancio-Silva, L., He, J., and Bhatia, S. N.
Cellular and Molecular Gastroenterology and Hepatology (2018)

Manuscript (PDF)

2017

Featured

Porous Silicon Nanoparticle Delivery of Tandem Peptide Anti-Infectives for the Treatment of Pseudomonas aeruginosa Lung Infections

E. J. Kwon, M. Skalak, A. Bertucci, G. Braun, F. Ricci, E. Ruoslahti, M. J. Sailor, S. N. Bhatia
Adv Mater Weinheim. (2017)

Manuscript (PDF), Supporting information (PDF)

Towards a Humanized Mouse Model of Liver Stage Malaria Using Ectopic Artificial Livers

S. Ng, March, S., Galstian, A., Gural, N., Stevens, K. R., Mota, M. M., and Bhatia, S. N., Scientific Reports, vol. 7, no. 45424, 2017.

Manuscript (PDF), Supporting information (PDF)

Ultrasensitive tumour-penetrating nanosensors of protease activity

E. J. Kwon†, Dudani, J. S. †, and Bhatia, S. N.
Nature Biomedical Engineering (2017)

Manuscript (PDF), Supporting information (PDF)

In situ expansion of engineered human liver tissue in a mouse model of chronic liver disease

K. R. Stevens, M.A. Scull, V. Ramanan, C.L. Fortin, R.R. Chaturvedi, K.A. Knouse, J.W. Xiao, C. Fung, T. Mirabella, A.X. Chen, M.G. McCue, M.T. Yang, H.E. Fleming, K. Chung, Y.P. de Jong, C.S. Chen, C.M. Rice, and S.N. Bhatia.
Science Translational Medicine (2017)

Manuscript (PDF), Supporting information (PDF)

Depolarization signatures map gold nanorods within biological tissue

N. Lippok, Villiger, M., Albanese, A., Meijer, E. F. J., Chung, K., Padera, T. P., Bhatia, S. N., and Bouma, B. E.
Nature Photonics (2017)

Manuscript (PDF), Supporting information (PDF)

Future cancer research priorities in the USA: a Lancet Oncology Commission

E. M. Jaffee, Van Dang, C., Agus, D. B., Alexander, B. M., Anderson, K. C., Ashworth, A., Barker, A. D., Bastani, R., Bhatia, S., Bluestone, J. A., Brawley, O., Butte, A. J., Coit, D. G., Davidson, N. E., Davis, M., DePinho, R. A., Diasio, R. B., Draetta, G., A Frazier, L., Futreal, A., Gambhir, S. S., Ganz, P. A., Garraway, L., Gerson, S., Gupta, S., Heath, J., Hoffman, R. I., Hudis, C., Hughes-Halbert, C., Ibrahim, R., Jadvar, H., Kavanagh, B., Kittles, R., Le, Q. - T., Lippman, S. M., Mankoff, D., Mardis, E. R., Mayer, D. K., McMasters, K., Meropol, N. J., Mitchell, B., Naredi, P., Ornish, D., Pawlik, T. M., Peppercorn, J., Pomper, M. G., Raghavan, D., Ritchie, C., Schwarz, S. W., Sullivan, R., Wahl, R., Wolchok, J. D., Wong, S. L., and Yung, A.
The Lancet Oncology (2017)

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A robust cell culture system supporting the complete life cycle of hepatitis B virus

E. Michailidis, Pabon, J., Xiang, K., Park, P., Ramanan, V., Hoffmann, H. - H., Schneider, W. M., Bhatia, S. N., de Jong, Y. P., Shlomai, A., and Rice, C. M., “A robust cell culture system supporting the complete life cycle of hepatitis B virus”, Scientific Reports, vol. 7, no. 1, 2017.

Manuscript (PDF), Supporting information (PDF)

Tumor-Penetrating Delivery of siRNA against TNFα to Human Vestibular Schwannomas

Y. Ren, Sagers, J. E., Landegger, L. D., Bhatia, S. N., and Stankovic, K. M., “Tumor-Penetrating Delivery of siRNA against TNFα to Human Vestibular Schwannomas”, Scientific Reports, vol. 7, no. 1, 2017.

Manuscript (PDF), Supporting information (PDF)

Potential role of intratumor bacteria in mediating tumor resistance to the chemotherapeutic drug gemcitabine

L. T. Geller†, Barzily-Rokni, M. †, Danino, T., Jonas, O. H., Shental, N., Nejman, D., Gavert, N., Zwang, Y., Cooper, Z. A., Shee, K., Thaiss, C. A., Reuben, A., Livny, J., Avraham, R., Frederick, D. T., Ligorio, M., Chatman, K., Johnston, S. E., Mosher, C. M., Brandis, A., Fuks, G., Gurbatri, C., Gopalakrishnan, V., Kim, M., Hurd, M. W., Katz, M., Fleming, J., Maitra, A., Smith, D. A., Skalak, M., Bu, J., Michaud, M., Trauger, S. A., Barshack, I., Golan, T., Sandbank, J., Flaherty, K. T., Mandinova, A., Garrett, W. S., Thayer, S. P., Ferrone, C. R., Huttenhower, C., Bhatia, S. N., Gevers, D., Wargo, J. A., Golub, T. R., and Straussman, R.
Science (2017)

Manuscript (PDF), Supporting information (PDF)

2016

Featured

Extracellular matrix microarrays to study inductive signaling for endoderm specification

D. F. B. Malta, N. E. Reticker-Flynn, C. L. da Silva, J. M. S. Cabral, H. E. Fleming, K. S. Zaret, S. N. Bhatia, G. H. Underhill
Acta Biomater. (2016)

Manuscript + Supporting information (PDF)

Voices of biotech

Amit et al.
Nature Biotechnology. (2016)

Manuscript + Supporting information (PDF)

Sustained-Release Synthetic Biomarkers for Monitoring Thrombosis and Inflammation Using Point-of-Care Compatible Readouts

J. S. Dudani, C. G. Buss, R. T. K. Akana, G. A. Kwong, S. N. Bhatia
Adv. Funct. Mater. (2016)

Manuscript + Supporting information (PDF)

Porous silicon–graphene oxide core–shell nanoparticles for targeted delivery of siRNA to the injured brain

J. Joo, E. J. Kwon, J. Kang, M. Skalak, E. J. Anglin, A. P. Mann, E. Ruoslahti, S. N. Bhatia, M. J. Sailor
Nanoscale Horizons (2016)

Manuscript + Supporting information (PDF)

Infection of laboratory colonies of Anopheles mosquitoes with Plasmodium vivax from cryopreserved clinical isolates

K. Shaw-Saliba, D. Clarke, J. M. Santos, M. J. Menezes, C. Lim, A. Mascarenhas, L. Chery, E. Gomes, S. March, S. N. Bhatia
Int. J. Parasitol. (2016)

Manuscript (PDF)

Development of Light-Activated CRISPR Using Guide RNAs with Photocleavable Protectors

P. K. Jain, V. Ramanan, A. G. Schepers, N. S. Dalvie, A. Panda, H. E. Fleming, S. N. Bhatia
Angew Chem Int Ed. (2016)

Manuscript + Supporting information (PDF)

Viral genome imaging of hepatitis C virus to probe heterogeneous viral infection and responses to antiviral therapies

V. Ramanan, K. Trehan, M.-L. Ong, J. M. Luna, H.-H. Hoffmann, C. Espiritu, T. P. Sheahan, H. Chandrasekar, R. E. Schwartz, K. S. Christine, C. M. Rice, A. van Oudenaarden, S. N. Bhatia
Virology. (2016)

Manuscript (PDF), Supporting information (PDF)

Diversity-oriented synthesis yields novel multistage antimalarial inhibitors

N. Kato†, Comer, E. †, Sakata-Kato, T., Sharma, A., Sharma, M., Maetani, M., Bastien, J., Brancucci, N. M., Bittker, J. A., Corey, V., Clarke, D., Derbyshire, E. R., Dornan, G., Duffy, S., Eckley, S., Itoe, M. A., Koolen, K. M. J., Lewis, T. A., Lui, P. S., Lukens, A. K., Lund, E., March, S., Meibalan, E., Meier, B. C., McPhail, J., Mitasev, B., Moss, E. L., Sayes, M., VanGessel, Y., Wawer, M. J., Yoshinaga, T., Zeeman, A. - M., Avery, V. M., Bhatia, S. N., Burke, J. E., Catteruccia, F., Clardy, J. C., Clemons, P. A., Dechering, K. J., Duvall, J. R., Foley, M. A., Gusovsky, F., Kocken, C. H. M., Marti, M., Morningstar, M. L., Munoz, B., Neafsey, D. E., Sharma, A., Winzeler, E. A., Wirth, D. F., Scherer, C. A., and Schreiber, S. L.
Nature (2016)

Manuscript (PDF)

Host AMPK Is a Modulator of Plasmodium Liver Infection

M. T. Grilo Ruivo, Vera, I. Medina, Sales-Dias, J., Meireles, P., Gural, N., Bhatia, S. N., Mota, M. M. ‡, and Mancio-Silva, L. ‡
Cell Rep. (2016)

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Comparison of Modular PEG Incorporation Strategies for Stabilization of Peptide–siRNA Nanocomplexes

J. H. Lo†, Kwon, E. J. †, Zhang, A. Q., Singhal, P., and Bhatia, S. N.
Bioconjugate Chemistry (2016)

Manuscript (PDF)

2015

Featured

In vitro alterations do not reflect a requirement for host cell cycle progression during Plasmodium liver stage infection

K. Hanson, S. March, S. Ng, S.N. Bhatia, M.M. Mota
Eukaryotic Cell (2015)

Manuscript + Supporting Information (PDF)

Aberrant glycosylation promotes lung cancer metastasis through adhesion to galectins in the metastatic niche

N. Reticker-Flynn, S.N. Bhatia
Cancer Discovery (2015)

Manuscript + Supporting Information (PDF)

Human iPSC-derived hepatocyte-like cells support Plasmodium liver-stage infection in vitro

S. Ng, R. E. Schwartz, S. March, A. Galstian, N. Gural, J. Shan, M. Prabhu, M. M. Mota, S. N. Bhatia
Stem Cell Reports (2015)

Manuscript + Supporting Information (PDF)

Patterning Vascular Networks In Vivo for Tissue Engineering Applications

R. R. Chaturvedi, K. R. Stevens, R. D. Solorzano, R. E. Schwartz, J. Eyckmans, J. D. Baranski, S. C. Stapleton, S. N. Bhatia, C. S. Chen
Tissue Eng. Part C Methods (2015)

Manuscript (PDF)

Programmable probiotics for detection of cancer in urine

T. Danino, A. Prindle, G. A. Kwong, M. Skalak, H. Li, K. Allen, J. Hasty, S. N. Bhatia
Science Translational Medicine (2015)

Manuscript (PDF)

CRISPR/Cas9 cleavage of viral DNA efficiently suppresses hepatitis B virus

V. Ramanan, A. Shlomai, D. B. T. Cox, R. E. Schwartz, E. Michailidis, A. Bhatta, D. A. Scott, F. Zhang, C. M. Rice, S. N. Bhatia
Scientific Reports (2015)

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A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malaria

M. A. Phillips, J. Lotharius, K. Marsh, J. White, A. Dayan, K. L. White, J. W. Njoroge, F. El Mazouni, Y. Lao, S. Kokkonda, D. R. Tomchick, X. Deng, T. Laird, S. N. Bhatia, S. March, C. L. Ng, D. A. Fidock, S. Wittlin, M. Lafuente-Monasterio, F. J. G. Benito, L. M. S. Alonso, M. S. Martinez, M. B. Jimenez-Diaz, S. F. Bazaga, I. Angulo-Barturen, J. N. Haselden, J. Louttit, Y. Cui, A. Sridhar, A.-M. Zeeman, C. Kocken, R. Sauerwein, K. Dechering, V. M. Avery, S. Duffy, M. Delves, R. Sinden, A. Ruecker, K. S. Wickham, R. Rochford, J. Gahagen, L. Iyer, E. Riccio, J. Mirsalis, I. Bathhurst, T. Rueckle, X. Ding, B. Campo, D. Leroy, M. J. Rogers, P. K. Rathod, J. N. Burrows, S. A. Charman
Science Translational Medicine (2015)

Manuscript (PDF), Supporting information (PDF)

Endothelial Thermotolerance Impairs Nanoparticle Transport in Tumors

A. F. Bagley, R. Scherz-Shouval, P. A. Galie, A. Q. Zhang, J. Wyckoff, L. Whitesell, C. S. Chen, S. Lindquist, S. N. Bhatia
Cancer Research (2015)

Manuscript (PDF)

Micropatterned coculture of primary human hepatocytes and supportive cells for the study of hepatotropic pathogens

S. March, V. Ramanan, K. Trehan, S. Ng, A. Galstian, N. Gural, M. A. Scull, A. Shlomai, M. M. Mota, H. E. Fleming, S. R. Khetani, C. M. Rice, S. N. Bhatia
Nature Protocols (2015)

Manuscript (PDF)

Smart nanosystems: Bio-inspired technologies that interact with the host environment

E. J. Kwon, J. H. Lo, S. N. Bhatia
PNAS (2015)

Manuscript (PDF)

Photoactivated Spatiotemporally-Responsive Nanosensors of in Vivo Protease Activity

J. S. Dudani, P. K. Jain, G. A. Kwong, K. R. Stevens, S. N. Bhatia
ACS Nano (2015)

Manuscript + Supporting information (PDF)

Degradable hydrogels derived from peg-diacrylamide for hepatic tissue engineering

Stevens, K.R., Miller, J.S., Blakely, B.L., Chen, C.S., and Bhatia, S.N.
J Biomed Mater Res A (2015)

Manuscript (PDF)

Quantifying co-cultured cell phenotypes in high-throughput using pixel-based classification

Logan, D.J., Shan, J., Bhatia, S.N., and Carpenter, A.E.
Methods (2015)

Manuscript (PDF), Supporting information (PDF)

Mathematical framework for activity-based cancer biomarkers

Kwong, G.A., Dudani, J.S., Carrodeguas, E., Mazumdar, E.V., Zekavat, S.M., and Bhatia, S.N.
PNAS (2015)

Manuscript and supporting information (PDF)

2014

Featured

Hypoxia promotes liver-stage malaria infection in primary human hepatocytes in vitro

S. Ng, S. March, A. Galstian, K. Hanson, T. Carvalho, M. M. Mota and S. N. Bhatia
Dis Model Mech (2014)

Manuscript + Supporting information (PDF)

Weighing nanoparticles in solution at the attogram scale

S. Olcum, N. Cermak, S. C. Wasserman, K. S. Christine, H. Atsumi, K. R. Payer, W. Shen, J. Lee, A. M. Belcher, S. N. Bhatia, S. R. Manalis
PNAS (2014)

Manuscript + Supporting information (PDF)

Micropatterned Cell–Cell Interactions Enable Functional Encapsulation of Primary Hepatocytes in Hydrogel Microtissues

C. Y. Li, K. R. Stevens, R. E. Schwartz, B. S. Alejandro, J. H. Huang, S. N. Bhatia
Tissue Eng. Part A (2014)

Manuscript (PDF), Supporting information (PDF)

Pluripotent stem cell-derived hepatocyte-like cells

R.E. Schwartz, H.E. Fleming, S.R. Khetani, S.N. Bhatia
Bioetchnol. Adv. (2014)

Manuscript (PDF)

Point-of-care diagnostics for noncommunicable diseases using synthetic urinary biomarkers and paper microfluidics

A. D. Warren, G. A. Kwong, D. K. Wood, K. Y. Lin, S. N. Bhatia
PNAS (2014)

Manuscript (PDF)

Macro-to-Micro Interface for the Control of Cellular Organization

E. E. Hui, C. Li, A. Agrawal, S. N. Bhatia
Journal of Microelectromechanical Systems (2014)

Manuscript (PDF)

Cell and tissue engineering for liver disease

S. N. Bhatia, G. H. Underhill, K. S. Zaret, I. J. Fox
Science Translational Medicine (2014)

Manuscript (PDF)

Mechanisms of cooperation in cancer nanomedicine: towards systems nanotechnology

S. Hauert, S.N. Bhatia
Trends Biotechnology (2014)

Manuscript (PDF)

Modeling host interactions with hepatitis B virus using primary and induced pluripotent stem cell-derived hepatocellular systems.

A. Shlomai, R. E. Schwartz, V. Ramanan, A. Bhatta, Y. P. de Jong, S. N. Bhatia, C. M. Rice
PNAS (2014)

Manuscript (PDF)

Microfluidic organs-on-chips

S. N. Bhatia, D. E. Ingber
Nature Biotechnology (2014)

Manuscript (PDF)

Self-titrating anticoagulant nanocomplexes that restore homeostatic regulation of the coagulation cascade.

K. Y. Lin, J. H. Lo, N. Consul, G. A. Kwong, S. N. Bhatia
ACS Nano (2014)

Manuscript + Supporting Information (PDF)

Deep, noninvasive imaging and surgical guidance of submillimeter tumors using targeted M13-stabilized single-walled carbon nanotubes

D. Ghosh, A. F. Bagley, Y. J. Na, M. J. Birrer, S. N. Bhatia, A. M. Belcher
PNAS (2014)

Manuscript + Supporting Information (PDF)

Disease detection by ultrasensitive quantification of microdosed synthetic urinary biomarkers.

A. D. Warren, S. T. Gaylord, K. C. Ngan, M. Dumont Milutinovic, G. A. Kwong, S. N. Bhatia, D. R. Walt
J Am Chem Soc (2014)

Manuscript + Supporting Information (PDF)

Drug-induced amplification of nanoparticle targeting to tumors

K. Y. Lin, E. J. Kwon, J. H. Lo, S. N. Bhatia
Nano Today (2014)

Manuscript + Supporting Information (PDF)

Host cell phosphatidylcholine is a key mediator of malaria parasite survival during liver stage infection

M. A. Itoe, J. L. Sampaio, G. G. Cabal, E. Real, V. Zuzarte-Luis, S. March, S. N. Bhatia, F. Frischknecht, C. Thiele, A. Shevchenko, M. M. Mota
Cell Host Microbe (2014)

Manuscript + Supporting Information (PDF)

New Methods in Tissue Engineering: Improved Models for Viral Infection

V. Ramanan, M. A. Scull, T. P. Sheahan, C. M. Rice, and S. N. Bhatia.
Annu. Rev. Virol. (2014)

Manuscript (PDF)

2013

Featured

Flow-based pipeline for systematic modulation and analysis of 3D tumor microenvironments

C. Y. Li, D. K. Wood, J. H. Huang, S. N. Bhatia
Lab Chip (2013)

Manuscript + Supporting information (PDF)

InVERT molding for scalable control of tissue microarchitecture

K. R. Stevens, M. D. Ungrin, R. E. Schwartz, S. Ng, B. Carvalho, K. S. Christine, R. R. Chaturvedi, C. Y. Li, P. W. Zandstra, C. S. Chen, S. N. Bhatia
Nature Communications (2013)

Manuscript + Supporting information (PDF)

Geometric control of vascular networks to enhance engineered tissue integration and function

J. D. Baranski, R. R. Chaturvedi, K. R. Stevens, J. Eyckmans, B. Carvalho, R. D. Solorzano, M. T. Yang, J. S. Miller, S. N. Bhatia, C. S. Chen
PNAS (2013)

Manuscript + Supporting information (PDF)

Mitochondrial localization and the persistent migration of epithelial cancer cells

S.P. Desai, S. N. Bhatia, M. Toner, D. Irimia
Biophysics Journal (2013)

Manuscript + Supporting information (PDF)

Nanoparticle amplification via photothermal unveiling of cryptic collagen binding sites

J. H. Lo, G. von Maltzahn, J. Douglass, J.-H. Park, M. J. Sailor, E. Ruoslahti, S. N. Bhatia
J Mater Chem B Mater Biol Med. (2013)

Manuscript (PDF)

Nanotechnology: emerging tools for biology and medicine

I.Y. Wong, S.N. Bhatia, M. Toner
Genes Dev (2013)

Manuscript (PDF)

A microscale human liver platform that supports the hepatic stages of Plasmodium falciparum and vivax

S. March, S. Ng, S. Velmurugan, A. Galstian, J. Shan, D. J. Logan, A. E. Carpenter, D. Thomas, B. K. L. Sim, M. M. Mota, S. L. Hoffman, S. N. Bhatia
Cell Host and Microbe (2013)

Manuscript (PDF)

Measuring Growth and Gene Expression Dynamics of Tumor-Targeted S. Typhimurium Bacteria

T. Danino, A. Prindle, J. Hasty, S.N. Bhatia
JOVE (2013)

Manuscript (PDF)

Plasmonic photothermal heating of intraperitoneal tumors through the use of an implanted near-infrared source

A. F. Bagley, S. Hill, G. S. Rogers, S. N. Bhatia
ACS Nano (2013)

Manuscript + Supporting information (PDF)

Nanoparticles that sense thrombin activity as synthetic urinary biomarkers of thrombosis

K. Y. Lin, G. A. Kwong, A. D. Warren, D. K. Wood, S. N. Bhatia
ACS Nano (2013)

Manuscript + Supporting information (PDF)

HeLiVa platform: integrated heart-liver-vascular systems for drug testing in human health and disease

G. Vunjak-Novakovic, S. Bhatia, C. Chen, K. Hirschi
Stem Cell Res Ther (2013)

Manuscript + Supporting information (PDF)

A computational framework for Identifying design guidelines to increase the penetration of targeted nanoparticles into tumors

S. Hauert, S. Berman, R. Nagpal, S. N. Bhatia
Nano Today (2013)

Manuscript + Supporting information (PDF)

Identification of small molecules for human hepatocyte expansion and iPS differentiation

J. Shan, R.E. Schwartz, N.T. Ross, D.J. Logan, D. Thomas, S.A Duncan, T.E. North, W. Goessling, A.E. Carpenter, and S.N. Bhatia
Nature Chemical Biology (2013)

Manuscript (PDF), Supporting information (PDF)

Mass-encoded synthetic biomarkers for multiplexed urinary monitoring of disease

G. A. Kwong, G. von Maltzahn, G. Murugappan, O. Abudayyeh, S. Mo, I. A. Papayannopoulos, D.Y. Sverdlov, S. B. Liu, A.D. Warren, Y. Popov, D. Schuppan, and S.N. Bhatia
Nature Biotechnology (2013)

Manuscript (PDF), Supporting information (PDF)

2012

Featured

In Vivo Gene Expression Dynamics of Tumor-Targeted Bacteria

T. Danino, J. Lo, A. Prindle, J. Hasty, S. N. Bhatia,
ACS Synthetic Biology (2012)

Manuscript + Supporting information (PDF)

Genetic Circuits in Salmonella typhimurium

A. Prindle, J. Selimkhanov, T. Danino, P. Samayoa, A. Goldberg, S. N. Bhatia, J. Hasty
ACS Synthetic Biology (2012)

Manuscript + Supporting information (PDF)

Bioengineering Methods for Analysis of Cells In Vitro

G. H. Underhill, P. Galie, C.S. Chen, S. N. Bhatia
Annu. Rev. Cell Dev. Biol. (2012)

Manuscript (PDF)

A combinatorial extracellular matrix platform identifies cell-extracellular matrix interactions that correlate with metastasis

N. E. Reticker-Flynn, D. F. B. Malta, M. M. Winslow, J. M. Lamar, M. J. Xu, G. H. Underhill, R. O. Hynes, T. E. Jacks, S. N. Bhatia
Nature Communications (2012)

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Critical role for lysyl oxidase in mesenchymal stem cell-driven breast cancer malignancy

C. P. El-Haibi, G. W. Bell, J. Zhang, A. Y. Collmann, D. Wood, C. M. Scherber, E. Csizmadia, O. Mariani, C. Zhu, A. Campagne, M. Toner, S. N. Bhatia, D. Irimia, A. Vincent-Salomon, A. E. Karnoub
PNAS (2012)

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Cancer Vulnerabilities Unveiled by Genomic Loss

D. Nijhawan, T. I. Zack, Y. Ren, M. R. Strickland, R. Lamothe, S. E. Schumacher, A. Tsherniak, H. C. Besche, J. Rosenbluh, S. Shehata, G. S. Cowley, B. A. Weir, A. L. Goldberg, J. P. Mesirov, D. E. Root, S. N. Bhatia, R. Beroukhim, W. C. Hahn
Cell (2012)

Manuscript + Supporting information (PDF)

The challenges posed by cancer heterogeneity

S.N. Bhatia, J.V. Frangioni, R. M. Hoffman, A. J. Iafrate, K. Polyak
Nature Biotechnology (2012)

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Rapid casting of patterned vascular networks for perfusable engineered three-dimensional tissues

J. S. Miller, K. R. Stevens, M. T. Yang, B. M. Baker, D.-H. T. Nguyen, D. M. Cohen, E. Toro, A. A. Chen, P. A. Galie, X. Yu, R. Chaturvedi, S. N. Bhatia, C. S. Chen
Nature Materials (2012)

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A Biophysical Indicator of Vaso-occlusive Risk in Sickle Cell Disease

D. K. Wood, A. Soriano, L. Mahadevan, J. M. Higgins S. N. Bhatia
Science Translational Medicine (2012)

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Modeling hepatitis C virus infection using human induced pluripotent stem cells

R. E. Schwartz, K. Trehan, L. Andrus, T. P. Sheahan, A. Ploss, S. A. Duncan, C. M. Rice, S. N. Bhatia
PNAS (2012)

Manuscript (PDF)

What is the greatest regulatory challenge in the translation of biomaterials to the clinic?

G. D. Prestwich, S. Bhatia, C. K. Breuer, S. L. M. Dahl, C. Mason, R. McFarland, D. J. McQuillan, J. Sackner-Bernstein, J. Schox, W. E. Tente, A. Trounson
Science Translational Medicine (2012)

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Targeted tumor-penetrating siRNA nanocomplexes for credentialing the ovarian cancer oncogene ID4

Y. Ren, H. W. Cheung, G. von Maltzhan, A. Agrawal, G.S. Cowley, B. A. Weir, J. S. Boehm, P. Tamayo, A. M. Karst, J. F. Liu, M. S. Hirsch, J. P. Mesirov, R. Drapkin, D. E. Root, J. Lo, V. Fogal, E. Ruoslahti, W. C. Hahn,* S. N. Bhatia*
Science Translational Medicine (2012)

Manuscript (PDF), Supporting information (PDF)

Identification and characterization of receptor-specific peptides for siRNA delivery.

Y. Ren, S. Hauert, J. Lo, S.N.Bhatia
ACS Nano, Volume 6, Issue 10, p.8620-31 (2012)

2011

Featured

Expression of paramyxovirus V proteins promotes replication and spread of hepatitis C virus in cultures of primary human fetal liver cells

Andrus, Linda; Marukian, Svetlana; Jones, Christopher T; Catanese, Maria Teresa; Sheahan, Timothy P; Schoggins, John W; Barry, Walter T; Dustin, Lynn B; Trehan, Kartik; Ploss, Alexander; Sangeeta N Bhatia; Rice, Charles M
Hepatology (2011)

Manuscript (PDF)

Bioresponsive mesoporous silica nanoparticles for triggered drug release

Singh, Neetu; Karambelkar, Amrita; Gu, Luo; Kevin Y Lin; Miller, Jordan S; Chen, Christopher S; Sailor, Michael J; Sangeeta N Bhatia
Journal of the American Chemical Society (2011)

Manuscript (PDF)

DNA-templated assembly of droplet-derived PEG microtissues

Li, Cheri Y; Wood, David K; Hsu, Caroline M; Sangeeta N Bhatia
Lab on a Chip (2011)

Manuscript (PDF)

Humanized mice with ectopic artificial liver tissues

A.A. Chen, D. K. Thomas, L.L. Ong, L. Luvena, R.E. Schwartz, T.R. Golub, S.N. Bhatia.
PNAS (2011)

Manuscript (PDF)

Systematic investigation of genetic vulnerabilities across cancer cell lines reveals lineage-specific dependencies in ovarian cancer

Cheung, Hiu Wing; Cowley, Glenn S; Weir, Barbara A; Boehm, Jesse S; Rusin, Scott; Scott, Justine A; East, Alexandra; Ali, Levi D; Lizotte, Patrick H; Wong, Terence C; Jiang, Guozhi; Hsiao, Jessica; Mermel, Craig H; Getz, Gad; Barretina, Jordi; Gopal, Shuba; Tamayo, Pablo; Gould, Joshua; Tsherniak, Aviad; Stransky, Nicolas; Luo, Biao; Ren, Yin; Drapkin, Ronny; Sangeeta N Bhatia; Mesirov, Jill P; Garraway, Levi A; Meyerson, Matthew; Lander, Eric S; Root, David E; Hahn, William C
PNAS (2011)

Manuscript (PDF)

Nanoparticles that communicate in vivo to amplify tumour targeting

von Maltzahn, Geoffrey; Park, Ji-Ho; Kevin Y Lin; Singh, Neetu; Schwöppe, Christian; Mesters, Rolf; Berdel, Wolfgang E; Ruoslahti, Erkki; Sailor, Michael J; Sangeeta N Bhatia
Nature Materials (2011)

Manuscript (PDF)

In-silico patterning of vascular mesenchymal cells in three dimensions

Tal Danino; Volfson, Dmitri; Sangeeta N Bhatia; Tsimring, Lev; Jeff Hasty
PLoS One (2011)

Manuscript (PDF)

Nanoparticle-mediated delivery of siRNA targeting Parp1 extends survival of mice bearing tumors derived from Brca1-deficient ovarian cancer cells

Goldberg, Michael S; Xing, Deyin; Ren, Yin; Orsulic, Sandra; Sangeeta N Bhatia; Sharp, Phillip A
PNAS (2011)

Manuscript (PDF)

Gold nanorod photothermal therapy in a genetically engineered mouse model of soft tissue sarcoma

Kevin Y Lin†; Alexander F Bagley†; Alexia Y. Zhang; Daniel L. Karl; Sam S. Yoon; Sangeeta N Bhatia
Nano LIFE (2011)

Manuscript (PDF)

Nanoparticles that communicate in vivo to amplify tumour targeting

G. von Maltzahn, J.H. Park, K. Y. Lin, N. Singh, C. Schwöppe, R. Mesters, W. E. Berdel, E. Ruoslahti, M. J. Sailor, and S. N. Bhatia
Nature Materials (2011)

Manuscript (PDF), Supplementary information (PDF)

2010

Featured

Multiplexed, high-throughput analysis of 3D microtissue suspensions

Chen, Alice A; Underhill, Gregory H; Sangeeta N Bhatia
Integrative Biology (2010)

Manuscript (PDF)

Ligand-clustered "patchy" nanoparticles for modulated cellular uptake and in vivo tumor targeting

Poon, Zhiyong; Chen, Shujun; Engler, Amanda C; Lee, Hyung-il; Atas, Evrim; von Maltzahn, Geoffrey; Sangeeta N Bhatia; Hammond, Paula T
Angewandte Chemie (2010)

Manuscript (PDF)

Single cell trapping and DNA damage analysis using microwell arrays

Wood, David K; Weingeist, David M; Sangeeta N Bhatia‡; Bevin P Engelward‡
PNAS (2010)

Manuscript (PDF)

Microfluidics-integrated time-lapse imaging for analysis of cellular dynamics

Dirk R Albrecht†; Gregory H Underhill†; Resnikoff, Joshua; Mendelson, Avital; Sangeeta N Bhatia; Shah, Jagesh V
Integrative Biology (2010)

Manuscript (PDF)

Effect of nanoparticle conjugation on gene silencing by RNA interference

Singh, Neetu; Agrawal, Amit; Leung, Anthony K L; Sharp, Phillip A; Sangeeta N Bhatia
Journal of American Chemical Society (2010)

Manuscript (PDF)

Targeting of drugs and nanoparticles to tumors.

Ruoslahti, Erkki; Sangeeta N Bhatia; Sailor, Michael J
Journal of Cell Biology (2010)

Manuscript (PDF)

Cooperative nanoparticles for tumor detection and photothermally triggered drug delivery

Park, Ji-Ho; von Maltzahn, Geoffrey; Ong, Luvena L; Centrone, Andrea; Hatton, T Alan; Ruoslahti, Erkki; Sangeeta N Bhatia; Sailor, Michael J
Advanced Materials (2010)

Manuscript (PDF)

The pipeline still leaks and more than you think: a status report on gender diversity in biomedical engineering

Chesler, Naomi C; Barabino, Gilda; Sangeeta N Bhatia; Richards-Kortum, Rebecca
Annual Biomedical Engineering (2010)

Manuscript (PDF)

Real-time imaging of hepatitis C virus infection using a fluorescent cell-based reporter system

Jones, Christopher T; Catanese, Maria Teresa; Law, Lok Man J; Khetani, Salman R; Syder, Andrew J; Ploss, Alexander; Oh, Thomas S; Schoggins, John W; MacDonald, Margaret R; Sangeeta N Bhatia; Rice, Charles M
Nature Biotechnology (2010)

Manuscript (PDF)

Cooperative nanomaterial system to sensitize, target, and treat tumors

Park, Ji-Ho; von Maltzahn, Geoffrey; Xu, Mary Jue; Fogal, Valentina; Kotamraju, Venkata Ramana; Ruoslahti, Erkki; Sangeeta N Bhatia; Sailor, Michael J
PNAS (2010)

Manuscript (PDF)

Tissue-specific gene delivery via nanoparticle coating

Todd J Harris†; Jordan J Green†; Fung, Peter W; Langer, Robert; Daniel G Anderson‡; Sangeeta N Bhatia‡
Biomaterials (2010)

Manuscript (PDF)

Persistent hepatitis C virus infection in microscale primary human hepatocyte cultures

A. Ploss, S. R. Khetani, C. T. Jones, A. J. Syder, K. Trehan, V. A. Gaysinskaya, K. Mu, K. Ritola, C. M. Rice, and S. N. Bhatia
Proceedings of the National Academy of Sciences (2010)

Manuscript (PDF), Supporting information (PDF)

2009

Featured

Probing nanoantenna-directed photothermal destruction of tumors using noninvasive laser irradiation

DasGupta, Debabrata; von Maltzahn, Geoffrey; Ghosh, Soham; Sangeeta N Bhatia; Das, Sarit K.; Chakraborty, Suman
Applied Physics Letters (2009)

Manuscript (PDF)

SERS-Coded Gold Nanorods as a Multifunctional Platform for Densely Multiplexed Near-Infrared Imaging and Photothermal Heating

von Maltzahn, Geoffrey; Centrone, Andrea; Park, Ji-Ho; Ramanathan, Renuka; Sailor, Michael J; Hatton, T Alan; Sangeeta N Bhatia
Advanced Materials (2009)

Manuscript (PDF)

Silicon nanoparticles as hyperpolarized magnetic resonance imaging agents

Aptekar, Jacob W; Cassidy, Maja C; Johnson, Alexander C; Barton, Robert A; Lee, Menyoung; Ogier, Alexander C; Vo, Chinh; Anahtar, Melis N; Ren, Yin; Sangeeta N Bhatia; Ramanathan, Chandrasekhar; Cory, David G; Hill, Alison L; Mair, Ross W; Rosen, Matthew S; Walsworth, Ronald L; Marcus, Charles M
ACS Nano (2009)

Manuscript (PDF)

Functional delivery of siRNA in mice using dendriworms

Agrawal, Amit; Min, Dal-Hee; Singh, Neetu; Zhu, Haihao; Birjiniuk, Alona; von Maltzahn, Geoffrey; Harris, Todd J; Xing, Deyin; Woolfenden, Stephen D; Sharp, Phillip A; Charest, Alain; Sangeeta N Bhatia
ACS Nano (2009)

Manuscript (PDF)

Microenvironmental regulation of the sinusoidal endothelial cell phenotype in vitro

March, Sandra; Hui, Elliot E; Underhill, Gregory H; Khetani, Salman; Sangeeta N Bhatia
Hepatology (2009)

Manuscript (PDF)

Differential proteomics analysis of the surface heterogeneity of dextran iron oxide nanoparticles and the implications for their in vivo clearance

Simberg, Dmitri; Park, Ji-Ho; Karmali, Priya P; Zhang, Wan-Ming; Merkulov, Sergei; McCrae, Keith; Sangeeta N Bhatia; Sailor, Michael; Ruoslahti, Erkki
Biomaterials (2009)

Manuscript (PDF)

Computationally guided photothermal tumor therapy using long-circulating gold nanorod antennas

von Maltzahn, Geoffrey; Park, Ji-Ho; Agrawal, Amit; Bandaru, Nanda Kishor; Das, Sarit K; Sailor, Michael J; Sangeeta N Bhatia
Cancer Research (2009)

Manuscript (PDF)

Systematic surface engineering of magnetic nanoworms for in vivo tumor targeting

Park, Ji-Ho; von Maltzahn, Geoffrey; Zhang, Lianglin; Derfus, Austin M; Simberg, Dmitri; Harris, Todd J; Ruoslahti, Erkki; Sangeeta N Bhatia; Sailor, Michael J
Small (2009)

Manuscript (PDF)

Biodegradable luminescent porous silicon nanoparticles for in vivo applications

Park, Ji-Ho; Gu, Luo; von Maltzahn, Geoffrey; Ruoslahti, Erkki; Sangeeta N Bhatia; Sailor, Michael J
Nature Materials (2009)

Manuscript (PDF)

Statistical dynamics of flowing red blood cells by morphological image processing

Higgins, John M; Eddington, David T; Sangeeta N Bhatia; Mahadevan, L
PLoS Computational Biology (2009)

Manuscript (PDF)

Modulation of hepatocyte phenotype in vitro via chemomechanical tuning of polyelectrolyte multilayers

Chen, Alice A; Khetani, Salman R; Lee, Sunyoung; Sangeeta N Bhatia; Van Vliet, Krystyn J
Biomaterials (2009)

Manuscript (PDF)

The compatibility of hepatocytes with chemically modified porous silicon with reference to in vitro biosensors

Alvarez, Sara D; Derfus, Austin M; Schwartz, Michael P; Sangeeta N Bhatia; Sailor, Michael J
Biomaterials (2009)

Manuscript (PDF)

2008

Featured

In vivo tumor cell targeting with "click" nanoparticles

G. von Maltzahn, Y. Ren, J.-H. Park, D.-H. Min, V. R. Kotamraju, J. Jayakumar, V. Fogal, M. J. Sailor, E. Ruoslahti, S. N. Bhatia
Bioconjug Chem (2008)

Manuscript (PDF), Supporting information (PDF)

T-cadherin modulates hepatocyte functions in vitro

S. R. Khetani, A. A. Chen, B. Ranscht, S. N. Bhatia
FASEB Journal (2008)

Manuscript (PDF), Supporting information (PDF)

Protease-triggered unveiling of bioactive nanoparticles

T. J. Harris, G. von Maltzahn, M. E. Lord, J. Park, A. Agrawal, D. Min, M. J. Sailor, S. N. Bhatia
Small (2008)

Manuscript (PDF), Supporting information (PDF)

Micellar hybrid nanoparticles for simultaneous magnetofluorescent imaging and drug delivery

J. Park, G. von Maltzahn, E. Ruoslahti, S. N. Bhatia, M. J. Sailor
Angew Chem Int Ed. (2008)

Manuscript (PDF), Supporting information (PDF)

Combinatorial Signaling Microenvironments for Studying Stem Cell Fate

C. J. Flaim, D. Teng, S. Chein, S. N. Bhatia
Stem Cells and Development (2008)

Manuscript (PDF)

Magnetic Iron Oxide Nanoworms for Tumor Targeting and Imaging

J. Park, G. von Maltzahn, L. Zhang, M. P. Schwartz, E. Ruoslahti, S. N. Bhatia, M. J. Sailor
Advanced Materials (2008)

Manuscript (PDF)

Microscale culture of human liver cells for drug development

S. Khetani and S. Bhatia.
Nature Biotechnology (2008)

Manuscript (PDF), Supporting information (PDF)

2007

Featured

Nanoparticle Self-Assembly Directed by Antagonistic Kinase and Phosphatase Activities

von Maltzahn, Geoffrey; Min, Dal-Hee; Zhang, Y.; Park, Ji-Ho; Harris, Todd J; Sailor, Michael J; Sangeeta N Bhatia
Advanced Materials (2007)

Manuscript (PDF)

Sickle cell vasoocclusion and rescue in a microfluidic device

Higgins, J M; Eddington, D T; Sangeeta N Bhatia; Mahadevan, L
PNAS (2007)

Manuscript (PDF)

Remotely Triggered Release from Magnetic Nanoparticles

Derfus, Austin M; von Maltzahn, Geoffrey; Harris, Todd J; Duza, Tasmia; Kenneth S Vecchio; Ruoslahti, Erkki; Sangeeta N Bhatia
Advanced Materials (2007)

Manuscript (PDF)

Silicon microchips for manipulating cell-cell interaction

Hui, Elliot E; Sangeeta N Bhatia
Journal of Visualized Experiments (2007)

Manuscript (PDF)

High-throughput analysis of signals regulating stem cell fate and function

Underhill, Gregory H; Sangeeta N Bhatia
Current Opinion in Chemical Biology (2007)

Manuscript (PDF)

Targeted quantum dot conjugates for siRNA delivery

Derfus, Austin M; Chen, Alice A; Min, Dal-Hee; Ruoslahti, Erkki; Sangeeta N Bhatia
Bioconjugate Chemistry (2007)

Manuscript (PDF)

Laminin and fibronectin modulate inner ear spiral ganglion neurite outgrowth in an in vitro alternate choice assay

Evans, Amaretta R; Euteneuer, Sara; Chavez, Eduardo; Mullen, Lina M; Hui, Elliot E; Sangeeta N Bhatia; Ryan, Allen F
Developmental Neurobiology (2007)

Manuscript (PDF)

Multiphase electropatterning of cells and biomaterials

Albrecht, Dirk R; Underhill, Gregory H; Mendelson, Avital; Sangeeta N Bhatia
Lab Chip (2007)

Manuscript (PDF)

Nanoparticle Self-Assembly Gated by Logical Proteolytic Triggers

von Maltzahn, Geoffrey; Harris, Todd J; Park, Ji-Ho; Min, Dal-Hee; Schmidt, Alexander J; Sailor, Michael J; Sangeeta N Bhatia
Journal of the American Chemical Society (2007)

Manuscript (PDF)

Micromechanical control of cell-cell interactions

Hui, Elliot E; Sangeeta N Bhatia
PNAS (2007)

Manuscript (PDF)

Microscale control of cell contact and spacing via three-component surface patterning

Hui, Elliot E; Sangeeta N Bhatia
Langmuir (2007)

Manuscript (PDF)

Biomimetic amplification of nanoparticle homing to tumors

Simberg, Dmitri; Duza, Tasmia; Park, Ji Ho; Essler, Markus; Pilch, Jan; Zhang, Lianglin; Derfus, Austin M; Yang, Meng; Hoffman, Robert M; Sangeeta N Bhatia; Sailor, Michael J; Ruoslahti, Erkki
PNAS (2007)

Manuscript (PDF) Supplementary Figures (link)

Fabrication of 3D hepatic tissues by additive photopatterning of cellular hydrogels

Valerie Liu Tsang; Chen, Alice A; Cho, Lisa M; Jadin, Kyle D; Sah, Robert L; DeLong, Solitaire; West, Jennifer L; Sangeeta N Bhatia
FASEB J (2007)

Manuscript (PDF) Supplementary Figures (PDF)

Fabrication of three-dimensional tissues

Valerie Liu Tsang; Sangeeta N Bhatia
Advances in Biochemical Engineering (2007)

Assessment of hepatocellular function within PEG hydrogels

Underhill, Gregory H; Chen, Alice A; Albrecht, Dirk R; Sangeeta N Bhatia
Biomaterials (2007)

Manuscript (PDF)

2006

Featured

In vitro liver tissue model established from transgenic mice: role of HIF-1alpha on hypoxic gene expression

Allen, Jared W; Khetani, Salman R; Johnson, Randall S; Sangeeta N Bhatia
Tissue Engineering (2006)

Manuscript (PDF)

Engineering tissues for in vitro applications

Khetani, Salman R; Sangeeta N Bhatia
Current Opinions in Biotechnology (2006)

Manuscript (PDF)

The smart Petri dish: a nanostructured photonic crystal for real-time monitoring of living cells

Schwartz, Michael P; Derfus, Austin M; Alvarez, Sara D; Sangeeta N Bhatia; Sailor, Michael J
Langmuir (2006)

Manuscript (PDF)

Local heating of discrete droplets using magnetic porous silicon-based photonic crystals

Park, Ji-Ho; Derfus, Austin M; Segal, Ester; Kenneth S Vecchio; Sangeeta N Bhatia; Sailor, Michael J
Journal of the American Chemical Society (2006)

Manuscript (PDF)

Proteolytic actuation of nanoparticle self-assembly

Harris, Todd J; von Maltzahn, Geoffrey; Derfus, Austin M; Ruoslahti, Erkki; Sangeeta N Bhatia
Angewandte International Edition Chemie (2006)

Manuscript (PDF)

Probing the role of multicellular organization in three-dimensional microenvironments

Albrecht, Dirk R; Underhill, Gregory H; Wassermann, Travis B; Sah, Robert L; Sangeeta N Bhatia
Nature Methods (2006)

Manuscript (PDF)

2005

Featured

Quantum dots to monitor RNAi delivery and improve gene silencing

A. A. Chen, A. M. Derfus, S. R. Khetani, S.N. Bhatia
Nucleic Acids Research (2005)

Manuscript (PDF)

An extracellular matrix microarray for probing cellular differentiation

C. J. Flaim, S. Chien, S. N. Bhatia
Nature Methods (2005)

Manuscript (PDF), Supporting information (PDF)

Photo- and electropatterning of hydrogel-encapsulated living cell arrays

D. R. Albrecht, V. L. Tsang, R. L. Sah, S. N. Bhatia
Lab Chip (2005)

Manuscript (PDF)

In vitro zonation and toxicity in a hepatocyte bioreactor

J.W. Allen, S.R. Khetani, S. N. Bhatia
Toxicology Sciences (2005)

Manuscript (PDF)

Hypoxic inhibition of 3-methylcholanthrene-induced CYP1A1 expression is independent of HIF-1alpha

J.W. Allen, R.S. Johnson, S. N. Bhatia
Toxicology Letters (2005)

Manuscript (PDF)

2004

Featured

Intracellular Delivery of Quantum Dots for Live Cell Labeling and Organelle Tracking

Derfus, A. M.; Chan, W. C. W.; Sangeeta N Bhatia
Advanced Materials (2004)

Manuscript (PDF)

Probing the Cytotoxicity of Semiconductor Quantum Dots

Derfus, Austin M.; Chan, Warren C. W.; Sangeeta N Bhatia
Nano Letters (2004)

Manuscript (PDF)

Manipulation of liquid droplets using amphiphilic, magnetic one-dimensional photonic crystal chaperones

Dorvee, Jason R; Derfus, Austin M; Sangeeta N Bhatia; Sailor, Michael J
Nature Materials (2004)

Manuscript (PDF)

Microfabricated platform for studying stem cell fates

Chin, Vicki I; Taupin, Philippe; Sanga, Sandeep; Scheel, John; Gage, Fred H; Sangeeta N Bhatia
Biotechnology and Bioengineering (2004)

Manuscript (PDF)

Geometric and material determinants of patterning efficiency by dielectrophoresis

Albrecht, Dirk R; Sah, Robert L; Sangeeta N Bhatia
Biophysical Journal (2004)

Manuscript (PDF)

Assessing porcine liver-derived biomatrix for hepatic tissue engineering

Lin, Paul; Chan, Warren C W; Badylak, Stephen F; Sangeeta N Bhatia
Tissue Engineering (2004)

Manuscript (PDF)

Three-dimensional tissue fabrication.

Valerie Liu Tsang; Sangeeta N Bhatia
Advanced Drug Delivery Reviews (2004)

Manuscript (PDF)

Exploring interactions between rat hepatocytes and nonparenchymal cells using gene expression profiling.

Khetani, Salman R; Szulgit, Greg; Del Rio, Jo A; Barlow, Carrolee; Sangeeta N Bhatia
Hepatology (2004)

Manuscript (PDF)

2003

Featured

Fabrication of PLGA scaffolds using soft lithography and microsyringe deposition

G. Vozzi, C. Flaim, A Ahluwalia, S. N. Bhatia
Biomaterials (2003)

Manuscript (PDF)

Polymer replicas of photonic porous silicon for sensing and drug delivery applications

Y. Y. Li, F. Cunin, J. R. Link, T. Gao, R. E. Betts, S. H. Reiver, V. Chin, S. N. Bhatia, M. J. Sailor
Science (2003)

Manuscript (PDF)

Formation of steady-state oxygen gradients in vitro: application to liver zonation

J.W. Allen, S.N. Bhatia
Biotechnol Bioeng (2003)

Manuscript (PDF)

Anisotropic stretch-induced hypertrophy in neonatal ventricular myocytes micropatterned on deformable elastomers

S. M. Gopalan, C. Flaim, S. N. Bhatia, M. Hoshijima, R. Knoell, K.R. Chien, J. H. Omens, A. D. McCulloch
Biotechnol Bioeng (2003)

Manuscript (PDF)

2002

Featured

Three-Dimensional Photopatterning of Hydrogels Containing Living Cells

Liu, Valerie A.; Bhatia, Sangeeta N.
Biomedical Microdevices (2002)

Manuscript (PDF)

Electro-Optical Platform for the Manipulation of Live Cells

Mihrimah Ozkan; Pisanic, T.; Scheel, J.; Barlow, C.; S. Esener; Sangeeta N Bhatia
Langmuir (2002)

Manuscript (PDF)

Optical Addressing of Polymer Beads for Chip-Based Systems

Mihrimah Ozkan; Sangeeta N Bhatia; S. Esener
Sensors and Materials (2002)

Manuscript (PDF)

Gender and achievement-related beliefs among engineering students

Heyman, GD; Martyna, B; Sangeeta N Bhatia
Journal of Women and Minorities in Science and Engineering (2002)

Manuscript (PDF)

Microfabricated PLGA scaffolds: a comparative study for application to tissue engineering

Giovanni Vozzi; Christopher J. Flaim; Francesca Bianchi; Arti Ahluwalia; Sangeeta N Bhatia
Materials Science and Engineering (2002)

Manuscript (PDF)

Biomolecular screening with encoded porous-silicon photonic crystals

Cunin, Frédérique; Schmedake, Thomas A; Link, Jamie R; Li, Yang Yang; Koh, Jennifer; Sangeeta N Bhatia; Sailor, Michael J
Nature Materials (2002)

Manuscript (PDF)

Improving the next generation of bioartificial liver devices

Allen, Jared W; Sangeeta N Bhatia
Seminars in Cell and Developmental Biology (2002)

Manuscript (PDF)

Engineering liver therapies for the future

Allen, Jared W; Sangeeta N Bhatia
Tissue Engineering (2002)

Manuscript (PDF)

Nanocrystal targeting in vivo

Akerman, Maria E; Chan, Warren C W; Laakkonen, Pirjo; Sangeeta N Bhatia; Ruoslahti, Erkki
PNAS (2002)

Manuscript (PDF)

Engineering protein and cell adhesivity using PEO-terminated triblock polymers

Liu, Valerie A; Jastromb, William E; Sangeeta N Bhatia
Journal of Biomedical Materials Research (2002)

Manuscript (PDF)

2001

Featured

Heterogeneous integration through electrokinetic migration

Mihrimah Ozkan; Ozkan, Cengiz S.; Kibar, O.; Wang, M.M.; Sangeeta N Bhatia; S. Esener
IEEE (2001)

Manuscript (PDF)

Electrokinetic Assembly of Microsphere and Cellular Arrays

Mihrimah Ozkan; S. Esener; Sangeeta N Bhatia
Materials Research Society Symposia (2001)

Manuscript (PDF)

Compatibility of Primary Hepatocytes with Oxidized Nanoporous Silicon

Chin, V.; Collins, B. E.; Sailor, M. J.; Sangeeta N Bhatia
Advanced Materials (2001)

Manuscript (PDF)

Advances in bioartificial liver devices

Allen, J W; Hassanein, T; Sangeeta N Bhatia
Hepatology (2001)

Manuscript (PDF)

Effects of morphological patterning on endothelial cell migration

Li, S; Sangeeta N Bhatia; Hu, Y L; Shiu, Y T; Li, Y S; Usami, S; Chien, S
Biorheology (2001)

Manuscript (PDF)

1994-2000

Featured

Xenobiotic metabolism by cultured primary porcine hepatocytes

Behnia, K; Sangeeta N Bhatia; Jastromb, N; Balis, U; Sullivan, S; Yarmush, M; Toner, M
Tissue Eng (2000)

Manuscript (PDF)

Tissue Engineering at the Micro-Scale

Sangeeta N Bhatia; Chen, Christopher S.
Biomedical Microdevices (1999)

Manuscript (PDF)

Effect of cell-cell interactions in preservation of cellular phenotype: cocultivation of hepatocytes and nonparenchymal cells

Sangeeta N Bhatia; Balis, U J; Yarmush, M L; Toner, M
FASEB J (1999)

Manuscript (PDF)

Prenatal detection and mapping of a distal 8p deletion associated with congenital heart disease

Sangeeta N Bhatia; Suri, V; Bundy, A; Krauss, C M
Prenat Diagn (1999)

Manuscript (PDF)

Oxygen consumption characteristics of porcine hepatocytes

Balis, U J; Behnia, K; Dwarakanath, B; Sangeeta N Bhatia; Sullivan, S J; Yarmush, M L; Toner, M
Metab Eng (1999)

Manuscript (PDF)

Numerical model of fluid flow and oxygen transport in a radial-flow microchannel containing hepatocytes.

Ledezma, G A; Folch, A; Sangeeta N Bhatia; Balis, U J; Yarmush, M L; Toner, M
J Biomech Eng (1999)

Manuscript (PDF)

Engineered substrates for controlling cell-cell interactions

Sangeeta N Bhatia; Yarmush, M L; Toner, M
ASME (1997)

Manuscript (PDF)

Controlling cell interactions by micropatterning in co-cultures: hepatocytes and 3T3 fibroblasts

Sangeeta N Bhatia; Yarmush, M L; Toner, M
J Biomed Mater Res (1997)

Manuscript (PDF)

Zonal liver cell heterogeneity: effects of oxygen on metabolic functions of hepatocytes

Sangeeta N Bhatia; Toner, M; Foy, BD; Rotem, A; Tompkins, RG; Yarmush, ML
J Cell Eng (1996)

Manuscript (PDF)

Selective Adhesion of Hepatocytes on Patterned Surfaces

Bhatia, SN; Toner, M; Tompkins, RG; Yarmush, ML
Annals of the New York Academy of Sciences (1994)

Manuscript (PDF)

Oxygen Is a Factor Determining In Vitro Tissue Assembly: Effects on Attachment and Spreading of Hepatocytes

Avi Rotem, Mehmet Toner, Sangeeta Bhatia, Brent D. Foy, and Ronald G. Tompkins, and Martin L. Yarmush
Biotechnology and Bioengineering (1994)

Manuscript (PDF)

Books & Book Chapters

Books

Nahmias, Y and Bhatia, SN, eds. (2009) Methods in Bioengineering Series: Microdevices in Biology and Medicine. Artech House Publishers, Norwood, MA.
Bhatia, SN & Desai, T, eds. (2006) Volume III Therapeutic Micro/Nano Technology.BioMEMS and Biomedical Micro/Nano Technology (M. Ferrari, ed), Springer, NY.
Palsson, B and Bhatia, SN (2003): Tissue Engineering. Pearson Prentice Hall, NY, NY
Bhatia, SN. (1999): Microfabrication in Tissue Engineering and Bioartificial Organs. Kluwer Academic Press, MA

Book Chapters

Chen AX, Chhabra A, Fleming HE, Bhatia SN (2020): "Hepatic Tissue Engineering," in Principles of Tissue Engineering, R. Lanza, R. Langer, J. Vacanti, A. Atala (eds.), Elsevier, pp. 738-753. ISBN: 978-0-1282-1401-5 PDF
Vo TN, Chen AX, Smith QB, Chhabra A, Bhatia SN, Marti M (2020): "Integrated Technologies for Liver Tissue Engineering," in The Liver: Biology and Pathobiology, I.M. Arias, H.J. Alter, J.L. Boyer, D.E. Cohen, D.A. Shafritz, S.S. Thorgeirsson, A.W. Wolkoff (eds.), John Wiley & Sons Ltd, pp. 1028-1035. ISBN: 978-1-1194-3682-9 PDF
Kato N, March S, Bhatia SN, Marti M (2018): "Phenotypic Screening of Small Molecules with Antimalarial Activity for Three Different Parasitic Life Stages," in Phenotypic Screening, B. Warner (ed.), Springer Nature, pp. 41-52. ISBN: 978-1-4939-7846-5 PDF
Stevens KR, Schwartz RE, Ng S, Shan J, and Bhatia SN (2014): "Hepatic Tissue Engineering," in Principles of Tissue Engineering, 4th Edition, R. Lanza, R. Langer, and J.P. Vacanti (eds.), Elsevier, pp. 951-986. ISBN: 978-0-12-398358-9 PDF
Shan, J, Stevens, KR, Trehan, K, Underhill, GH, Chen, AA, and Bhatia, SN (2011).Hepatic tissue engineering, in Molecular Pathology of Liver Diseases. S.P.S. Monga (ed.), Springer Science, 321-342. (PDF)
Underhill, GH, Khetani, SR, Chen, AA, and Bhatia, SN (2010) Tissue engineering of the liver, in The Liver: Biology and Pathobiology, 5th edition. I.M. Arias (ed.), Wiley-Blackwell. 935-954.
Liu, WF, Hui, EE, Bhatia, SN, and Chen, CS (2008): Engineering cellular microenvironments. In Principles of Regenerative Medicine. Atala, A, Lanza, R, Thomson, JA, Nerem, RM, (eds.), Academic Press, 536-553.
Underhill GH, Khetani SR, Chen, AA, & Bhatia, SN. (2007), Liver Tissue Engineering, in: Principles of Tissue Engineering, Third Edition. R. Lanza, R. Langer, J.P. Vacanti (eds.), Elsevier, 707-732.
Hassanein T., Stange J, Bhatia, SN, and Mehta R (2007): Artificial Liver and Blood Cleansing Techniques, in: TRAUMA: Critical Care Volume 2. WC Wilson, CM Grande, DB Hoyt (eds.), Informa Healthcare
Harris, TJ, von Maltzahn, G, and Bhatia, SN (2006). Multifunctional Nanoparticles for Cancer Therapy, in: Nanotechnology for Cancer Therapy. M.M. Amiji (ed.), Taylor and Francis/CRC Press, 59-76. (PDF)
Harris, TJ, von Maltzahn, G, and Bhatia, SN (2006). Multifunctional Nanoparticles for Cancer Therapy, in: Nanotechnology for Cancer Therapy. M.M. Amiji (ed.), Taylor and Francis/CRC Press, 59-76.
Underhill, GH, Felix, J, Allen, JW, Tsang, VL, Khetani, SR, Bhatia, SN. (2006), Tissue Engineering of the Liver, in: Culture of Cells for Tissue Engineering. G. Vunjak-Novakovic, R.I. Freshney (Eds.), John Wiley and Sons, 417-470.
Chen, A, Liu Tsang, V, Albrecht, D and Bhatia, SN (2006) 3-D fabrication technology for tissue engineering, in: BioMEMS and Biomedical Nanotechnology (M. Ferrarik, ed), Volume III: Therapeutic Micro/Nano Technology (T. Desai and S. Bhatia, eds), Springer, NY, p. 23-38.
Liu Tsang, V. and Bhatia, SN (2006): Fabrication of three-dimensional tissues, in:Advances in Biochemical Engineering/Biotechnology, special Vol: Tissue Engineering II: Basics of Tissue Engineering and Tissue Applications, K. Lee, D. Kaplan eds. Springer Berlin / Heidelberg, p. 189-205.
Bhatia, SN (2001): Micropatterned Cultures and Co-Cultures. Methods of Tissue Engineering, (Eds.) Atala and Lanza, Harcourt Academic Press, Ch 8: 121-129
Bhatia, SN, Yarmush, LM, and Toner M (1999): Micropatterning Cells in Tissue Engineering. Methods in Molecular Medicine, (Eds.) Morgan and Yarmush, Humana Press, Ch 4: 349-363

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