Compatibility of Primary Hepatocytes with Oxidized Nanoporous Silicon
PUBLICATION TYPE:
Journal Article
AUTHORS:
Chin, V.; Collins, B. E.; Sailor, M. J.; Sangeeta N Bhatia
SOURCE:
Advanced Materials, Volume 13, p.1877–1880 (2001)
URL:
http://dx.doi.org/10.1002/1521-4095(200112)13:24<1877::AID-ADMA1877>3.0.CO;2-4
ABSTRACT:
Porous silicon is a substrate highly compatible with living cells! Particularly after treatment of the surface with adhesive serum proteins, primary rat hepatocytes are easily attached while staying viable (shown by fluorescence microscopy with a vital dye—see Figure). Cells thus immobilized remain active even over a two week period, as their unchanged albumin and urea production reveals.