Publications
![Transient Support from Fibroblasts is Sufficient to Drive Functional Vascularization in Engineered Tissues](https://images.squarespace-cdn.com/content/v1/5e96377a2c8aee64d168790e/1616614770745-MDR9GJU3JY5H5TROCZ91/Song+2020.png)
Transient Support from Fibroblasts is Sufficient to Drive Functional Vascularization in Engineered Tissues
H.-H. G. Song, A. Lammers, S. Sundaram, L. Rubio, A. X. Chen, L. Li, J. Adv. Funct. Mat. (2020)
Manuscript (PDF)
![Peptide Spiders: Peptide–Polymer Conjugates to Traffic Nucleic Acids](https://images.squarespace-cdn.com/content/v1/5e96377a2c8aee64d168790e/1600194215680-FI9HXOWS1RGW20DYA20A/Screen%252BShot%252B2020-09-15%252Bat%252B2.19.50%252BPM.jpg)
![Mapping functional humoral correlates of protection against malaria challenge following RTS,S/AS01 vaccination](https://images.squarespace-cdn.com/content/v1/5e96377a2c8aee64d168790e/1612383788926-N6W2GSGK78JI88ZUA1N1/Suscovich+2020.png)
Mapping functional humoral correlates of protection against malaria challenge following RTS,S/AS01 vaccination
Suscovich, T. J., Fallon, J. K., Das, J., Demas, A. R., Crain, J., Linde, C. H., Michell, A., Natarajan, H., Arevalo, C., Broge, T., Linnekin, T., Kulkarni, V., Lu, R., Slein, M. D., Luedemann, C., Marquette, M., March, S., Weiner, J., Gregory, S., Coccia, M., Flores-Garcia, Y., Zavala, F., Ackerman, M. E., Bergmann-Leitner, E., Hendriks, J., Sadoff, J., Dutta, S., Bhatia, S. N., Lauffenburger, D. A., Jongert, E., Wille-Reece, U. & Alter, G.
Sci. Transl. Med. 12, (2020).
Manuscript (PDF), Supporting Information (PDF)
![Controlled apoptosis of stromal cells to engineer human microlivers](https://images.squarespace-cdn.com/content/v1/5e96377a2c8aee64d168790e/1600102338775-36SHSXPWU6B1WCEZMCQR/Screen%2BShot%2B2020-06-09%2Bat%2B2.03.47%2BPM.jpg)
Controlled apoptosis of stromal cells to engineer human microlivers
A.X. Chen, A. Chhabra, H.-H. G.Song, H.E. Fleming, C.S. Chen, and S.N. Bhatia
Advanced Functional Materials (2020)
Manuscript (PDF), Supporting Information (PDF)
![Nanoparticle delivery of immunostimulatory oligonucleotides enhances response to checkpoint inhibitor therapeutics](https://images.squarespace-cdn.com/content/v1/5e96377a2c8aee64d168790e/1612129879478-D0DGAPXRVOM6YFKHC1Z9/Buss+2020.png)
Nanoparticle delivery of immunostimulatory oligonucleotides enhances response to checkpoint inhibitor therapeutics
C. G. Buss and S. N. Bhatia
Proceedings of the National Academy of Sciences (2020)
Manuscript (PDF), Supporting Information (PDF)
![Pharmacokinetic tuning of protein–antigen fusions enhances the immunogenicity of T-cell vaccines](https://images.squarespace-cdn.com/content/v1/5e96377a2c8aee64d168790e/1612130002067-DC88FZBTT7C71UOY8B6O/Mehta+2020.png)
Pharmacokinetic tuning of protein–antigen fusions enhances the immunogenicity of T-cell vaccines
N. K. Mehta, Pradhan, R. V., Soleimany, A. P., Moynihan, K. D., Rothschilds, A. M., Momin, N., Rakhra, K., Mata-Fink, J., Bhatia, S. N., K. Wittrup, D., and Irvine, D. J.
Nature Biomedical Engineering. (2020)
Manuscript (PDF), Supporting Information (PDF)
![Cancer Cell–Derived Matrisome Proteins Promote Metastasis in Pancreatic Ductal Adenocarcinoma](https://images.squarespace-cdn.com/content/v1/5e96377a2c8aee64d168790e/1612383553583-F7LTEK7KDWPSCIPC8W31/Tian+2020.png)
Cancer Cell–Derived Matrisome Proteins Promote Metastasis in Pancreatic Ductal Adenocarcinoma
C. Tian, hlund, D. Ö., Rickelt, S., m, Tö, Huang, Y., Hao, L., Zhao, R. T., Franklin, O., Bhatia, S. N., Tuveson, D. A., and Hynes, R. O.
Cancer Research, vol. 80, no. 7, pp. 1461 - 1474 (2020)
Manuscript (PDF)
![Activity-Based Diagnostics: An emerging paradigm for disease detection and monitoring](https://images.squarespace-cdn.com/content/v1/5e96377a2c8aee64d168790e/1587653379127-X9SHMEERFMD6TTH96SLX/nn+soleimany+review.png)
Activity-Based Diagnostics: An emerging paradigm for disease detection and monitoring
A.P. Soleimany and S.N. Bhatia
Trends in Molecular Medicine (2020)
Manuscript (PDF)
![Urinary detection of lung cancer in mice via noninvasive pulmonary protease profiling](https://images.squarespace-cdn.com/content/v1/5e96377a2c8aee64d168790e/1612130114112-SWN7E9VH2NR57L03KK3Q/Kirkpatrick+2020.png)
Urinary detection of lung cancer in mice via noninvasive pulmonary protease profiling
J. D. Kirkpatrick, A. D. Warren, A. P. Soleimany, P. M. K. Westcott, J. C. Voog, C. Martin-Alonso, H. E. Fleming, T. Tammela, T. Jacks, and S. N. Bhatia
Science Translational Medicine (2020)
Manuscript (PDF), Supporting information (PDF)
![Genetic Encoding of Targeted Magnetic Resonance Imaging Contrast Agents for Tumor Imaging](https://images.squarespace-cdn.com/content/v1/5e96377a2c8aee64d168790e/1612130608207-QYKDEN0H57MZ3LT2QYJC/Schuerle%2B2020.jpg)
![Expansion, in vivo–ex vivo cycling, and genetic manipulation of primary human hepatocytes](https://images.squarespace-cdn.com/content/v1/5e96377a2c8aee64d168790e/1612383295814-E19G4D523PJVSBMHEC56/michalidis+2020.png)
Expansion, in vivo–ex vivo cycling, and genetic manipulation of primary human hepatocytes
E. Michailidis, K. Vercauteren, L. Mancio-Silva, L. Andrus, C. Jahan, I. Ricardo-Lax, C. Zou, M. Kabbani, P. Park, C. Quirk, C. Pyrgaki, B. Razooky, L. Verhoye, I. Zoluthkin, W. Lu, S.J. Forbes, L. Chiriboga, N.D. Theise, R.W. Herzog, H. Suemizu, W.M. Schneider, A. Shlomai, P. Meuleman, S.N. Bhatia, C.M. Rice, Y.P. de Jong.
Proc Natl Acad Sci USA 117, 1678–1688 (2020)
Manuscript (PDF), Supplementary Information (PDF)
![QnAs with Sangeeta N. Bhatia](https://images.squarespace-cdn.com/content/v1/5e96377a2c8aee64d168790e/1587143417704-UAQNPSPVT10JUUCBHHKU/Sangeeta+Bhatia.jpg)
![Engineering synthetic breath biomarkers for respiratory disease](https://images.squarespace-cdn.com/content/v1/5e96377a2c8aee64d168790e/1597081257620-2AL0ESVQ3ANYV89Q0ZMW/MIT-Smart-Breathalyzer-01_0.jpg)
Engineering synthetic breath biomarkers for respiratory disease
L.W. Chan, M.N. Anahtar, T.-H. Ong, K.E. Hern, R.R. Kunz, and S.N. Bhatia
Nature Nanotechnology (2020)
Manuscript (PDF), Supporting Information (PDF)