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Peptide Spiders: Peptide–Polymer Conjugates to Traffic Nucleic Acids

E. J. Kwon, H. Ko, S.N. Bhatia
Mol. Pharm. (2020)

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Nanoparticle delivery of immunostimulatory oligonucleotides enhances response to checkpoint inhibitor therapeutics

C. G. Buss and S. N. Bhatia
Proceedings of the National Academy of Sciences (2020)

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LMRT 6/5/20 LMRT 6/5/20

Pharmacokinetic tuning of protein–antigen fusions enhances the immunogenicity of T-cell vaccines

N. K. Mehta, Pradhan, R. V., Soleimany, A. P., Moynihan, K. D., Rothschilds, A. M., Momin, N., Rakhra, K., Mata-Fink, J., Bhatia, S. N., K. Wittrup, D., and Irvine, D. J.
Nature Biomedical Engineering. (2020)

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LMRT 6/5/20 LMRT 6/5/20

Cancer Cell–Derived Matrisome Proteins Promote Metastasis in Pancreatic Ductal Adenocarcinoma

C. Tian, hlund, D. Ö., Rickelt, S., m, Tö, Huang, Y., Hao, L., Zhao, R. T., Franklin, O., Bhatia, S. N., Tuveson, D. A., and Hynes, R. O.
Cancer Research, vol. 80, no. 7, pp. 1461 - 1474 (2020)

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Ultrasensitive tumour-penetrating nanosensors of protease activity

E. J. Kwon†, Dudani, J. S. †, and Bhatia, S. N.
Nature Biomedical Engineering (2017)

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LMRT 4/1/20 LMRT 4/1/20

Urinary detection of lung cancer in mice via noninvasive pulmonary protease profiling

J. D. Kirkpatrick, A. D. Warren, A. P. Soleimany, P. M. K. Westcott, J. C. Voog, C. Martin-Alonso, H. E. Fleming, T. Tammela, T. Jacks, and S. N. Bhatia
Science Translational Medicine (2020)

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Tumor penetrating nanomedicine targeting both an oncomiR and an oncogene in pancreatic cancer

M.-E. Gilles, L. Hao, K. Brown, J. Lim, S. N. Bhatia, F. J. Slack
Oncotarget. 10, 5349–5358 (2019).

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Renal clearable catalytic gold nanoclusters for in vivo disease monitoring

C. N. Loynachan †, A. P. Soleimany †, J. S. Dudani, Y. Lin, A. Najer, A. Bekdemir, Q. Chen, S. N. Bhatia, and M. M. Stevens
Nat. Nanotechnol. 14, 883–890 (2019).

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Acidification of tumor at stromal boundaries drives transcriptome alterations associated with aggressive phenotypes

Rohani, N., Hao, L., Alexis, M. S., Joughin, B. A., Krismer, K., Moufarrej, M. N., Soltis, A. R., Lauffenburger, D. A., Yaffe, M. B., Burge, C. B., Bhatia, S. N. & Gertler, F. B.
Cancer Res. 79, 1952–1966 (2019).

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LMRT 9/23/18 LMRT 9/23/18

Harnessing Protease Activity to Improve Cancer Care

J.S. Dudani, A.D. Warren, S.N. Bhatia.
Annu. Rev. Cancer Biol. 2, (2018).

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iRGD-guided tumor-penetrating nanocomplexes for therapeutic siRNA delivery to pancreatic cancer

J. H. Lo†, Hao, L. †, Muzumdar, M. D., Raghavan, S., Kwon, E. J., Pulver, E. M., Hsu, F., Aguirre, A. J., Wolpin, B. M., Fuchs, C. S., Hahn, W. C., Jacks, T., and Bhatia, S. N.
Molecular Cancer Therapeutics, vol. 17, no. 11, pp. 2377-2388, 2018.

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Classification of prostate cancer using a protease activity nanosensor library

J. S. Dudani, Ibrahim, M., Kirkpatrick, J., Warren, A. D., and Bhatia, S. N.
Proc Natl Acad Sci U S A, vol. 115, no. 36, pp. 8954-8959, 2018.

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Genome-scale analysis identifies paralog lethality as a vulnerability of chromosome 1p loss in cancer

S. R. Viswanathan, Nogueira, M. F., Buss, C. G., Krill-Burger, J. M., Wawer, M. J., Malolepsza, E., Berger, A. C., Choi, P. S., Shih, J., Taylor, A. M., Tanenbaum, B., Pedamallu, C. Sekhar, Cherniack, A. D., Tamayo, P., Strathdee, C. A., Lage, K., Carr, S. A., Schenone, M., Bhatia, S. N., Vazquez, F., Tsherniak, A., Hahn, W. C., and Meyerson, M.
Nature Genetics, vol. 50, no. 7, pp. 937 - 943, 2018.

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Personalized RNA-medicine for pancreatic cancer

M. - E. Gilles, Hao, L., Huang, L., Rupaimoole, R., Lopez-Casas, P. P., Pulver, E., Jeong, J. Cheol, Muthuswamy, S. K., Hidalgo, M., Bhatia, S. N., and Slack, F. J.
Clinical Cancer Research, vol. 24, no. 7, pp. 1734-1747, 2018.

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Tumor-Penetrating Delivery of siRNA against TNFα to Human Vestibular Schwannomas

Y. Ren, Sagers, J. E., Landegger, L. D., Bhatia, S. N., and Stankovic, K. M., “Tumor-Penetrating Delivery of siRNA against TNFα to Human Vestibular Schwannomas”, Scientific Reports, vol. 7, no. 1, 2017.

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Potential role of intratumor bacteria in mediating tumor resistance to the chemotherapeutic drug gemcitabine

L. T. Geller†, Barzily-Rokni, M. †, Danino, T., Jonas, O. H., Shental, N., Nejman, D., Gavert, N., Zwang, Y., Cooper, Z. A., Shee, K., Thaiss, C. A., Reuben, A., Livny, J., Avraham, R., Frederick, D. T., Ligorio, M., Chatman, K., Johnston, S. E., Mosher, C. M., Brandis, A., Fuks, G., Gurbatri, C., Gopalakrishnan, V., Kim, M., Hurd, M. W., Katz, M., Fleming, J., Maitra, A., Smith, D. A., Skalak, M., Bu, J., Michaud, M., Trauger, S. A., Barshack, I., Golan, T., Sandbank, J., Flaherty, K. T., Mandinova, A., Garrett, W. S., Thayer, S. P., Ferrone, C. R., Huttenhower, C., Bhatia, S. N., Gevers, D., Wargo, J. A., Golub, T. R., and Straussman, R.
Science (2017)

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