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Degradable hydrogels derived from peg-diacrylamide for hepatic tissue engineering

Stevens, K.R., Miller, J.S., Blakely, B.L., Chen, C.S., and Bhatia, S.N.
J Biomed Mater Res A (2015)

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Persistent hepatitis C virus infection in microscale primary human hepatocyte cultures

A. Ploss, S. R. Khetani, C. T. Jones, A. J. Syder, K. Trehan, V. A. Gaysinskaya, K. Mu, K. Ritola, C. M. Rice, and S. N. Bhatia
Proceedings of the National Academy of Sciences (2010)

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Controlled apoptosis of stromal cells to engineer human microlivers

A.X. Chen, A. Chhabra, H.-H. G.Song, H.E. Fleming, C.S. Chen, and S.N. Bhatia
Advanced Functional Materials (2020)

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Towards a Humanized Mouse Model of Liver Stage Malaria Using Ectopic Artificial Livers

S. Ng, March, S., Galstian, A., Gural, N., Stevens, K. R., Mota, M. M., and Bhatia, S. N., Scientific Reports, vol. 7, no. 45424, 2017.

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LMRT 1/10/20 LMRT 1/10/20

Expansion, in vivo–ex vivo cycling, and genetic manipulation of primary human hepatocytes

E. Michailidis, K. Vercauteren, L. Mancio-Silva, L. Andrus, C. Jahan, I. Ricardo-Lax, C. Zou, M. Kabbani, P. Park, C. Quirk, C. Pyrgaki, B. Razooky, L. Verhoye, I. Zoluthkin, W. Lu, S.J. Forbes, L. Chiriboga, N.D. Theise, R.W. Herzog, H. Suemizu, W.M. Schneider, A. Shlomai, P. Meuleman, S.N. Bhatia, C.M. Rice, Y.P. de Jong.
Proc Natl Acad Sci USA 117, 1678–1688 (2020)

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Targeting Liver Stage Malaria With Metformin

Vera, I. M., Grilo Ruivo, M. T., Lemos Rocha, L. F., Marques, S., Bhatia, S. N., Mota, M. M. & Mancio-Silva, L.
JCI Insight 4, (2019)

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Antimalarial Activity of Primaquine Operates via a Two-Step Biochemical Relay

Camarda, G., Jirawatcharadech, P., Priestley, R. S., Saif, A., March, S., Wong, M. H. L., Leung, S., Miller, A. B., Baker, D. A., Alano, P., Paine, M. J. I., Bhatia, S. N., O’Neill, P. M., Ward, S. A. & Biagini, G. A.
Nat. Commun. 10, 3226 (2019)

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Steroid Hormone Function Controls Non-competitive Plasmodium Development in Anopheles

Werling, K., Shaw, W. R., Itoe, M. A., Westervelt, K. A., Marcenac, P., Paton, D. G., Peng, D., Singh, N., Smidler, A. L., South, A., Deik, A. A., Mancio-Silva, L., Demas, A. R., March, S., Calvo, E., Bhatia, S. N., Clish, C. B. & Catteruccia, F.
Cell. 177, 315-325.e14 (2019).

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Improving drug discovery by nucleic acid delivery in engineered human microlivers

L. Mancio-Silva, H. E. Fleming, A. B. Miller, S. Milstein, A. Liebow, P. Haslett, L. Sepp-Lorenzino, and S. N. Bhatia.
Cell Metabolism (2019)

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Estrogen Activation of G protein-coupled Estrogen Receptor 1 Regulates Phosphoinositide 3-kinase and mTOR Signaling to Promote Liver Growth in Zebrafish and Proliferation of Human Hepatocytes

S. Chaturantabut, Shwartz, A., Evason, K. J., Cox, A. G., Labella, K., Schepers, A. G., Yang, S., Aravena, M., Houvras, iv, Y., Mancio-Silva, L., Romano, S., Gorelick, D. A., Cohen, D. E., Zon, L. I., Bhatia, S. N., North, T. E., and Goessling, W.
Gastroenterology, 2019

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A Plasmodium berghei sporozoite-based vaccination platform against human malaria

A. M. Mendes, Machado, M., alves-Rosa, Nç, Reuling, I. J., Foquet, L., Marques, áudia, Salman, A. M., Yang, A. S. P., Moser, K. A., Dwivedi, A., Hermsen, C. C., nez-Díaz, éné, Viera, S., Santos, J. M., Albuquerque, ês, Bhatia, S. N., Bial, J., Angulo-Barturen, ñigo, Silva, J. C., Leroux-Roels, G., Janse, C. J., Khan, S. M., Mota, M. M., Sauerwein, R. W., and Prudêncio, M.
npj Vaccines, vol. 3, 2018.

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A human monoclonal antibody prevents malaria infection by targeting a new site of vulnerability on the parasite

Kisalu, N.K., Idris, A.H., Weidle, C., Flores-Garcia, Y., Flynn, B.J., Sack, B.K., Murphy, Schön A., Freire, E., Francica, J.R., Miller, A.B., Gregory, J., March, S., Liao, H.X., Haynes, B.F., Wiehe, K., Trama, A.M., Saunders, K.O., Gladden, M.A., Monroe, A., Bonsignori, M., Kanekiyo, M., Wheatley, A.K., McDermott, A.B., Farney, S.K., Chuang, G.Y., Zhang, B., Kc, N., Chakravarty, S., Kwong, P.D., Sinnis, P., Bhatia, S.N., Kappe, S.H.I., Sim, B.K.L., Hoffman, S.L., Zavala, F., Pancera, M., and Seder, R.A.
Nature Medicine (2018)

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In vitro culture, drug sensitivity, and transcriptome of plasmodium vivax hypnozoites

N. Gural, L. Mancio-Silva, A.B. Miller, A. Galstian, V.L. Butty, S.S. Levine, R. Patrapuvich, S.P. Desai, S.A. Mikolajczak, S.H.I. Kappe, H.E. Fleming, S. March, J. Sattabongkot, and S.N. Bhatia
Cell Host & Microbe (2018)

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Engineered Livers for Infectious Diseases

N. Gural, Mancio-Silva, L., He, J., and Bhatia, S. N.
Cellular and Molecular Gastroenterology and Hepatology (2018)

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A robust cell culture system supporting the complete life cycle of hepatitis B virus

E. Michailidis, Pabon, J., Xiang, K., Park, P., Ramanan, V., Hoffmann, H. - H., Schneider, W. M., Bhatia, S. N., de Jong, Y. P., Shlomai, A., and Rice, C. M., “A robust cell culture system supporting the complete life cycle of hepatitis B virus”, Scientific Reports, vol. 7, no. 1, 2017.

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Host AMPK Is a Modulator of Plasmodium Liver Infection

M. T. Grilo Ruivo, Vera, I. Medina, Sales-Dias, J., Meireles, P., Gural, N., Bhatia, S. N., Mota, M. M. ‡, and Mancio-Silva, L. ‡
Cell Rep. (2016)

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High-Throughput Platform for Identifying Molecular Factors Involved in Phenotypic Stabilization of Primary Human Hepatocytes In Vitro

J. Shan, Logan, D. J., Root, D. E., Carpenter, A. E., and Bhatia, S. N.
Journal of Biomolecular Screening (2016)

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Engineering a perfusable 3D human liver platform from iPS cells

A. Schepers, Li, C., Chhabra, A., Seney, B. Tschudy, and Bhatia, S.
Lab Chip, vol. 16, pp. 2644-2653 (2016)

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Infection of laboratory colonies of Anopheles mosquitoes with Plasmodium vivax from cryopreserved clinical isolates.

K. Shaw-Saliba, Clarke, D., Santos, J. M., Menezes, M. José, Lim, C., Mascarenhas, A., Chery, L., Gomes, E., March, S., Bhatia, S. N., Rathod, P. K., Ferreira, M. U., Catteruccia, F., and Duraisingh, M. T.
Int J Parasitol, vol. 46, no. 11, pp. 679-683 (2016)

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Viral genome imaging of hepatitis C virus to probe heterogeneous viral infection and responses to antiviral therapies

V. Ramanan†, Trehan, K. †, Ong, M. - L., Luna, J. M., Hoffmann, H. - H., Espiritu, C., Sheahan, T. P., Chandrasekar, H., Schwartz, R. E., Christine, K. S., Rice, C. M., van Oudenaarden, A., and Bhatia, S. N.
Virology, vol. 494, pp. 236 - 247 (2016)

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