Modeling hepatitis C virus infection using human induced pluripotent stem cells

Publication Type:

Journal Article

Authors:

R. E. Schwartz†, Trehan†, K., Andrus, L., Sheahan, T. P., Ploss, A., Duncan, S. A., Rice‡, C. M., and Bhatia‡, S. N.

Source:

Proc Natl Acad Sci U S A, vol. 109, no. 7, pp. 2544-8 (2012)

Abstract:

Human pathogens impact patient health through a complex interplay with the host, but models to study the role of host genetics in this process are limited. Human induced pluripotent stem cells (iPSCs) offer the ability to produce host-specific differentiated cellsand thus have the potential to transform the study of infectious disease; however, no iPSC models of infectious disease have been described. Here we report that hepatocyte-like cells derived from iPSCs support the entire life cycle of hepatitis C virus, including inflammatory responses to infection, enabling studies of how hostgenetics impact viral pathogenesis.

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