Publications

N. Gural, Mancio-Silva, L., He, J., and Bhatia, S. N., “Engineered Livers for Infectious Diseases”, Cellular and Molecular Gastroenterology and Hepatology, vol. 5, no. 2, pp. 131 - 144, 2018.

Manuscript.pdf

J. S. Dudani, Warren, A. D., and Bhatia, S. N., “Harnessing Protease Activity to Improve Cancer Care”, Annual Review of Cancer Biology, vol. 2, no. 1, 2018.

manuscript.pdf

S. N. Bhatia and Ingber, D. E., “Microfluidic organs-on-chips.”, Nat Biotechnol, vol. 32, no. 8, pp. 760-72, 2014.

Manuscript,

Related feature in Nature

A. Shlomai^†, Schwartz^†, R. E., Ramanan^†, V., Bhatta, A., de Jong, Y. P., Bhatia^‡, S. N., and Rice^‡, C. M., “Modeling host interactions with hepatitis B virus using primary and induced pluripotent stem cell-derived hepatocellular systems.”, Proc Natl Acad Sci U S A, vol. 111, no. 33, pp. 12193-8, 2014.

Manuscript + Supporting Information,

'In This Issue' highlight

S. Hauert and Bhatia, S. N., “Mechanisms of cooperation in cancer nanomedicine: towards systems nanotechnology.”, Trends Biotechnol, vol. 32, no. 9, pp. 448-55, 2014.

Manuscript

S. N. Bhatia^‡, Underhill, G. H., Zaret, K. S., and Fox, I. J., “Cell and tissue engineering for liver disease.”, Sci Transl Med, vol. 6, no. 245, p. 245sr2, 2014.

Manuscript

E. E. Hui, Li, C., Agrawal, A., and Bhatia, S. N., “Macro-to-Micro Interface for the Control of Cellular Organization”, Journal of Microelectromechanical Systems, vol. 23, pp. 391–397, 2014.

Manuscript

A. D. Warren^†, Kwong, G. A. ^†, Wood, D. K. ^†, Lin, K. Y., and Bhatia, S. N., “Point-of-care diagnostics for noncommunicable diseases using synthetic urinary biomarkers and paper microfluidics.”, Proc Natl Acad Sci U S A, vol. 111, no. 10, pp. 3671-6, 2014.

Manuscript + Supporting Information

C. Y. Li, Stevens, K. R., Schwartz, R. E., Alejandro, B. S., Huang, J. H., and Bhatia, S. N., “Micropatterned cell-cell interactions enable functional encapsulation of primary hepatocytes in hydrogel microtissues.”, Tissue Eng Part A, vol. 20, no. 15-16, pp. 2200-12, 2014.

Manuscript,

Supporting Information

R. E. Schwartz, Fleming, H. E., Khetani, S. R., and Bhatia, S. N., “Pluripotent stem cell-derived hepatocyte-like cells.”, Biotechnol Adv, vol. 32, no. 2, pp. 504-13, 2014.

Manuscript

S. Olcum^†, Cermak, N. ^†, Wasserman, S. C., Christine, K. S., Atsumi, H., Payer, K. R., Shen, W., Lee, J., Belcher, A. M., Bhatia, S. N., and Manalis, S. R., “Weighing nanoparticles in solution at the attogram scale.”, Proc Natl Acad Sci U S A, vol. 111, no. 4, pp. 1310-5, 2014.

Manuscript + Supporting Information

S. Ng, March, S., Galstian, A., Hanson, K., Carvalho, T., Mota, M. M., and Bhatia, S. N., “Hypoxia promotes liver-stage malaria infection in primary human hepatocytes in vitro.”, Dis Model Mech, vol. 7, no. 2, pp. 215-24, 2014.

Manuscript + Supporting Information

2013

G. A. Kwong, von Maltzahn, G., Murugappan, G., Abudayyeh, O., Mo, S., Papayannopoulos, I. A., Sverdlov, D. Y., Liu, S. B., Warren, A. D., Popov, Y., Schuppan, D., and Bhatia, S. N., “Mass-encoded synthetic biomarkers for multiplexed urinary monitoring of disease.”, Nat Biotechnol, vol. 31, no. 1, pp. 63-70, 2013.

Manuscript + Supporting Information

S. Hauert, Berman, S., Nagpal, R., and Bhatia, S. N., “A computational framework for identifying design guidelines to increase the penetration of targeted nanoparticles into tumors.”, Nano Today, vol. 8, no. 6, pp. 566-576, 2013.

Manuscript

G. Vunjak-Novakovic^‡, Bhatia, S. N., Chen, C., and Hirschi, K., “HeLiVa platform: integrated heart-liver-vascular systems for drug testing in human health and disease.”, Stem Cell Res Ther, vol. 4 Suppl 1, p. S8, 2013.

Manuscript

K. Y. Lin^†, Kwong, G. A. ^†, Warren, A. D., Wood, D. K., and Bhatia, S. N., “Nanoparticles that sense thrombin activity as synthetic urinary biomarkers of thrombosis.”, ACS Nano, vol. 7, no. 10, pp. 9001-9, 2013.

Manuscript + Supporting Information

A. F. Bagley, Hill, S., Rogers, G. S., and Bhatia, S. N., “Plasmonic photothermal heating of intraperitoneal tumors through the use of an implanted near-infrared source.”, ACS Nano, vol. 7, no. 9, pp. 8089-97, 2013.

Manuscript + Supporting Information

T. Danino^†, Prindle^†, A., Hasty, J., and Bhatia, S. N., “Measuring growth and gene expression dynamics of tumor-targeted S. typhimurium bacteria.”, J Vis Exp, no. 77, p. e50540, 2013.

Manuscript

S. March, Ng, S., Velmurugan, S., Galstian, A., Shan, J., Logan, D. J., Carpenter, A. E., Thomas, D., B Sim, K. Lee, Mota, M. M., Hoffman, S. L., and Bhatia, S. N., “A microscale human liver platform that supports the hepatic stages of Plasmodium falciparum and vivax.”, Cell Host Microbe, vol. 14, no. 1, pp. 104-15, 2013.

Manuscript + Supporting Information

I. Y. Wong, Bhatia, S. N., and Toner, M., “Nanotechnology: emerging tools for biology and medicine.”, Genes Dev, vol. 27, no. 22, pp. 2397-408, 2013.

Manuscript

J. Lo^†, von Maltzahn^†, G., Douglass, J., Park, J. - H., Sailor, M. J., Ruoslahti, E., and Bhatia, S. N., “Nanoparticle amplification via photothermal unveiling of cryptic collagen binding sites.”, J Mater Chem B Mater Biol Med, vol. 1, no. 39, pp. 5235-5240, 2013.

Manuscript

J. Shan, Schwartz, R. E., Ross, N. T., Logan, D. J., Thomas, D., Duncan, S. A., North, T. E., Goessling, W., Carpenter, A. E., and Bhatia, S. N., “Identification of small molecules for human hepatocyte expansion and iPS differentiation.”, Nat Chem Biol, vol. 9, no. 8, pp. 514-20, 2013.

Manuscript + Supporting Information

S. P. Desai, Bhatia, S. N., Toner, M., and Irimia, D., “Mitochondrial localization and the persistent migration of epithelial cancer cells.”, Biophys J, vol. 104, no. 9, pp. 2077-88, 2013.

Manuscript + Supporting Information

J. D. Baranski^†, Chaturvedi^†, R. R., Stevens^†, K. R., Eyckmans, J., Carvalho, B., Solorzano, R. D., Yang, M. T., Miller, J. S., Bhatia, S. N., and Chen, C. S., “Geometric control of vascular networks to enhance engineered tissue integration and function.”, Proc Natl Acad Sci U S A, vol. 110, no. 19, pp. 7586-91, 2013.

Manuscript + Supporting Information

K. R. Stevens, Ungrin, M. D., Schwartz, R. E., Ng, S., Carvalho, B., Christine, K. S., Chaturvedi, R. R., Li, C. Y., Zandstra, P. W., Chen, C. S., and Bhatia, S. N., “InVERT molding for scalable control of tissue microarchitecture.”, Nat Commun, vol. 4, p. 1847, 2013.

Manuscript + Supporting Information,

Featured in Nature

C. Y. Li^†, Wood^†, D. K., Huang, J. H., and Bhatia, S. N., “Flow-based pipeline for systematic modulation and analysis of 3D tumor microenvironments.”, Lab Chip, vol. 13, no. 10, pp. 1969-78, 2013.

Manuscript + Supporting Information

2012

G. D. Prestwich, Bhatia, S. N., Breuer, C. K., Dahl, S. L. M., Mason, C., McFarland, R., McQuillan, D. J., Sackner-Bernstein, J., Schox, J., Tente, W. E., and Trounson, A., “What is the greatest regulatory challenge in the translation of biomaterials to the clinic?”, Sci Transl Med, vol. 4, no. 160, p. 160cm14, 2012.

Full Text

T. Danino, Lo, J., Prindle, A., Hasty, J., and Bhatia, S. N., “In Vivo Gene Expression Dynamics of Tumor-Targeted Bacteria.”, ACS Synth Biol, vol. 1, no. 10, pp. 465-470, 2012.

Full Text + Supporting Info

A. Prindle, Selimkhanov, J., Danino, T., Samayoa, P., Goldberg, A., Bhatia, S. N., and Hasty, J., “Genetic Circuits in Salmonella typhimurium.”, ACS Synth Biol, vol. 1, no. 10, pp. 458-464, 2012.

Full Text + Supporting Info

G. H. Underhill, Galie, P., Chen, C. S., and Bhatia, S. N., “Bioengineering methods for analysis of cells in vitro.”, Annu Rev Cell Dev Biol, vol. 28, pp. 385-410, 2012.

Full Text

N. E. Reticker-Flynn, Malta, D. F. Braga, Winslow, M. M., Lamar, J. M., Xu, M. J., Underhill, G. H., Hynes, R. O., Jacks, T. E., and Bhatia, S. N., “A combinatorial extracellular matrix platform identifies cell-extracellular matrix interactions that correlate with metastasis.”, Nat Commun, vol. 3, p. 1122, 2012.

Full Text + Supporting Info,

Featured in Nature

C. P. El-Haibi, Bell, G. W., Zhang, J., Collmann, A. Y., Wood, D., Scherber, C. M., Csizmadia, E., Mariani, O., Zhu, C., Campagne, A., Toner, M., Bhatia, S. N., Irimia, D., Vincent-Salomon, A., and Karnoub, A. E., “Critical role for lysyl oxidase in mesenchymal stem cell-driven breast cancer malignancy.”, Proc Natl Acad Sci U S A, vol. 109, no. 43, pp. 17460-5, 2012.

Full Text + Supporting Info

Y. Ren, Hauert, S., Lo, J., and Bhatia, S. N., “Identification and characterization of receptor-specific peptides for siRNA delivery.”, ACS Nano, vol. 6, no. 10, pp. 8620-31, 2012.

Full Text + Supporting Info

D. Nijhawan, Zack, T. I., Ren, Y., Strickland, M. R., Lamothe, R., Schumacher, S. E., Tsherniak, A., Besche, H. C., Rosenbluh, J., Shehata, S., Cowley, G. S., Weir, B. A., Goldberg, A. L., Mesirov, J. P., Root, D. E., Bhatia, S. N., Beroukhim, R., and Hahn, W. C., “Cancer vulnerabilities unveiled by genomic loss.”, Cell, vol. 150, no. 4, pp. 842-54, 2012.

Full Text + Supporting Info

Y. Ren^†, Cheung^†, H. Wing, von Maltzahn, G., Agrawal, A., Cowley, G. S., Weir, B. A., Boehm, J. S., Tamayo, P., Karst, A. M., Liu, J. F., Hirsch, M. S., Mesirov, J. P., Drapkin, R., Root, D. E., Lo, J., Fogal, V., Ruoslahti, E., Hahn^‡, W. C., and Bhatia^‡, S. N., “Targeted tumor-penetrating siRNA nanocomplexes for credentialing the ovarian cancer oncogene ID4.”, Sci Transl Med, vol. 4, no. 147, p. 147ra112, 2012.

Full Text + Supporting Info

S. N. Bhatia, Frangioni, J. V., Hoffman, R. M., A Iafrate, J., and Polyak, K., “The challenges posed by cancer heterogeneity.”, Nat Biotechnol, vol. 30, no. 7, pp. 604-10, 2012.

Full Text

J. S. Miller, Stevens, K. R., Yang, M. T., Baker, B. M., Nguyen, D. - H. T., Cohen, D. M., Toro, E., Chen, A. A., Galie, P. A., Yu, X., Chaturvedi, R., Bhatia, S. N., and Chen, C. S., “Rapid casting of patterned vascular networks for perfusable engineered three-dimensional tissues.”, Nat Mater, vol. 11, no. 9, pp. 768-74, 2012.

Full Text + Supporting Info

D. K. Wood, Soriano, A., Mahadevan, L., Higgins, J. M., and Bhatia, S. N., “A biophysical indicator of vaso-occlusive risk in sickle cell disease.”, Sci Transl Med, vol. 4, no. 123, p. 123ra26, 2012.

Full Text + Supporting Info

R. E. Schwartz^†, Trehan^†, K., Andrus, L., Sheahan, T. P., Ploss, A., Duncan, S. A., Rice^‡, C. M., and Bhatia^‡, S. N., “Modeling hepatitis C virus infection using human induced pluripotent stem cells.”, Proc Natl Acad Sci U S A, vol. 109, no. 7, pp. 2544-8, 2012.

Full Text + Supporting Info

2011

L. Andrus, Marukian, S., Jones, C. T., Catanese, M. Teresa, Sheahan, T. P., Schoggins, J. W., Barry, W. T., Dustin, L. B., Trehan, K., Ploss, A., Bhatia, S. N., and Rice, C. M., “Expression of paramyxovirus V proteins promotes replication and spread of hepatitis C virus in cultures of primary human fetal liver cells.”, Hepatology, vol. 54, no. 6, pp. 1901-12, 2011.

Full Text

N. Singh, Karambelkar, A., Gu, L., Lin, K. Y., Miller, J. S., Chen, C. S., Sailor, M. J., and Bhatia, S. N., “Bioresponsive mesoporous silica nanoparticles for triggered drug release.”, J Am Chem Soc, vol. 133, no. 49, pp. 19582-5, 2011.

Full Text + Supporting Info

C. Y. Li, Wood, D. K., Hsu, C. M., and Bhatia, S. N., “DNA-templated assembly of droplet-derived PEG microtissues.”, Lab Chip, vol. 11, no. 17, pp. 2967-75, 2011.

Full Text + Supporting Info

A. A. Chen, Thomas, D. K., Ong, L. L., Schwartz, R. E., Golub, T. R., and Bhatia, S. N., “Humanized mice with ectopic artificial liver tissues.”, Proc Natl Acad Sci U S A, vol. 108, no. 29, pp. 11842-7, 2011.

Full Text + Supplement

H. Wing Cheung, Cowley, G. S., Weir, B. A., Boehm, J. S., Rusin, S., Scott, J. A., East, A., Ali, L. D., Lizotte, P. H., Wong, T. C., Jiang, G., Hsiao, J., Mermel, C. H., Getz, G., Barretina, J., Gopal, S., Tamayo, P., Gould, J., Tsherniak, A., Stransky, N., Luo, B., Ren, Y., Drapkin, R., Bhatia, S. N., Mesirov, J. P., Garraway, L. A., Meyerson, M., Lander, E. S., Root, D. E., and Hahn, W. C., “Systematic investigation of genetic vulnerabilities across cancer cell lines reveals lineage-specific dependencies in ovarian cancer.”, Proc Natl Acad Sci U S A, vol. 108, no. 30, pp. 12372-7, 2011.

Full Text + Supplement

G. von Maltzahn, Park, J. - H., Lin, K. Y., Singh, N., Schwöppe, C., Mesters, R., Berdel, W. E., Ruoslahti, E., Sailor, M. J., and Bhatia, S. N., “Nanoparticles that communicate in vivo to amplify tumour targeting.”, Nat Mater, vol. 10, no. 7, pp. 545-52, 2011.

Full Text + Supporting Info

T. Danino, Volfson, D., Bhatia, S. N., Tsimring, L., and Hasty, J., “In-silico patterning of vascular mesenchymal cells in three dimensions.”, PLoS One, vol. 6, no. 5, p. e20182, 2011.

Full Text

M. S. Goldberg, Xing, D., Ren, Y., Orsulic, S., Bhatia, S. N., and Sharp, P. A., “Nanoparticle-mediated delivery of siRNA targeting Parp1 extends survival of mice bearing tumors derived from Brca1-deficient ovarian cancer cells.”, Proc Natl Acad Sci U S A, vol. 108, no. 2, pp. 745-50, 2011.

Full Text + Supplement

2010

K. Y. Lin^†, Bagley^†, A. F., Zhang, A. Y., Karl, D. L., Yoon, S. S., and Bhatia, S. N., “Gold nanorod photothermal therapy in a genetically engineered mouse model of soft tissue sarcoma”, Nano LIFE, vol. 01, no. 03n04, pp. 277 - 287, 2010.

Full Text + Supplement

A. A. Chen, Underhill, G. H., and Bhatia, S. N., “Multiplexed, high-throughput analysis of 3D microtissue suspensions.”, Integr Biol (Camb), vol. 2, no. 10, pp. 517-27, 2010.

Full Text + Supporting Info

Z. Poon, Chen, S., Engler, A. C., Lee, H. -il, Atas, E., von Maltzahn, G., Bhatia, S. N., and Hammond, P. T., “Ligand-clustered "patchy" nanoparticles for modulated cellular uptake and in vivo tumor targeting.”, Angew Chem Int Ed Engl, vol. 49, no. 40, pp. 7266-70, 2010.

Full Text + Supporting Info

D. K. Wood, Weingeist, D. M., Bhatia^‡, S. N., and Engelward^‡, B. P., “Single cell trapping and DNA damage analysis using microwell arrays.”, Proc Natl Acad Sci U S A, vol. 107, no. 22, pp. 10008-13, 2010.

Full Text + Supporting Info

D. R. Albrecht^†, Underhill^†, G. H., Resnikoff, J., Mendelson, A., Bhatia, S. N., and Shah, J. V., “Microfluidics-integrated time-lapse imaging for analysis of cellular dynamics.”, Integr Biol (Camb), vol. 2, no. 5-6, pp. 278-87, 2010.

Full Text + Supporting Info

N. Singh, Agrawal, A., Leung, A. K. L., Sharp, P. A., and Bhatia, S. N., “Effect of nanoparticle conjugation on gene silencing by RNA interference.”, J Am Chem Soc, vol. 132, no. 24, pp. 8241-3, 2010.

Full Text + Supporting Info

E. Ruoslahti, Bhatia, S. N., and Sailor, M. J., “Targeting of drugs and nanoparticles to tumors.”, J Cell Biol, vol. 188, no. 6, pp. 759-68, 2010.

Full Text

J. - H. Park, von Maltzahn, G., Ong, L. L., Centrone, A., T Hatton, A., Ruoslahti, E., Bhatia, S. N., and Sailor, M. J., “Cooperative nanoparticles for tumor detection and photothermally triggered drug delivery.”, Adv Mater, vol. 22, no. 8, pp. 880-5, 2010.

Full Text + Supporting Info

N. C. Chesler, Barabino, G., Bhatia, S. N., and Richards-Kortum, R., “The pipeline still leaks and more than you think: a status report on gender diversity in biomedical engineering.”, Ann Biomed Eng, vol. 38, no. 5, pp. 1928-35, 2010.

Full Text

A. Ploss^†, Khetani^†, S. R., Jones, C. T., Syder, A. J., Trehan, K., Gaysinskaya, V. A., Mu, K., Ritola, K., Rice^‡, C. M., and Bhatia^‡, S. N., “Persistent hepatitis C virus infection in microscale primary human hepatocyte cultures.”, Proc Natl Acad Sci U S A, vol. 107, no. 7, pp. 3141-5, 2010.

Full Text + Supporting Info

C. T. Jones, Catanese, M. Teresa, Law, L. Man J., Khetani, S. R., Syder, A. J., Ploss, A., Oh, T. S., Schoggins, J. W., MacDonald, M. R., Bhatia, S. N., and Rice, C. M., “Real-time imaging of hepatitis C virus infection using a fluorescent cell-based reporter system.”, Nat Biotechnol, vol. 28, no. 2, pp. 167-71, 2010.

Full Text + Supporting Info

J. - H. Park, von Maltzahn, G., Xu, M. Jue, Fogal, V., Kotamraju, V. Ramana, Ruoslahti, E., Bhatia, S. N., and Sailor, M. J., “Cooperative nanomaterial system to sensitize, target, and treat tumors.”, Proc Natl Acad Sci U S A, vol. 107, no. 3, pp. 981-6, 2010.

Full Text + Supporting Info

T. J. Harris^†, Green^†, J. J., Fung, P. W., Langer, R., Anderson^‡, D. G., and Bhatia^‡, S. N., “Tissue-specific gene delivery via nanoparticle coating.”, Biomaterials, vol. 31, no. 5, pp. 998-1006, 2010.

Full Text

2009

D. DasGupta, von Maltzahn, G., Ghosh, S., Bhatia, S. N., Das, S. K., and Chakraborty, S., “Probing nanoantenna-directed photothermal destruction of tumors using noninvasive laser irradiation”, Applied Physics Letters, vol. 95, p. -, 2009.

Full Text

G. von Maltzahn, Centrone, A., Park, J. - H., Ramanathan, R., Sailor, M. J., T Hatton, A., and Bhatia, S. N., “SERS-Coded Gold Nanorods as a Multifunctional Platform for Densely Multiplexed Near-Infrared Imaging and Photothermal Heating.”, Adv Mater, vol. 21, no. 31, pp. 3175-3180, 2009.

Full Text + Supporting Info

J. W. Aptekar, Cassidy, M. C., Johnson, A. C., Barton, R. A., Lee, M., Ogier, A. C., Vo, C., Anahtar, M. N., Ren, Y., Bhatia, S. N., Ramanathan, C., Cory, D. G., Hill, A. L., Mair, R. W., Rosen, M. S., Walsworth, R. L., and Marcus, C. M., “Silicon nanoparticles as hyperpolarized magnetic resonance imaging agents.”, ACS Nano, vol. 3, no. 12, pp. 4003-8, 2009.

Full Text + Supporting Info

A. Agrawal, Min, D. - H., Singh, N., Zhu, H., Birjiniuk, A., von Maltzahn, G., Harris, T. J., Xing, D., Woolfenden, S. D., Sharp, P. A., Charest, A., and Bhatia, S. N., “Functional delivery of siRNA in mice using dendriworms.”, ACS Nano, vol. 3, no. 9, pp. 2495-504, 2009.

Full Text + Supporting Info

S. March, Hui, E. E., Underhill, G. H., Khetani, S., and Bhatia, S. N., “Microenvironmental regulation of the sinusoidal endothelial cell phenotype in vitro.”, Hepatology, vol. 50, no. 3, pp. 920-8, 2009.

Full Text + Supporting Info

D. Simberg, Park, J. - H., Karmali, P. P., Zhang, W. - M., Merkulov, S., McCrae, K., Bhatia, S. N., Sailor, M., and Ruoslahti, E., “Differential proteomics analysis of the surface heterogeneity of dextran iron oxide nanoparticles and the implications for their in vivo clearance.”, Biomaterials, vol. 30, no. 23-24, pp. 3926-33, 2009.

Full Text + Supporting Information,

Supplemental Data 1,

Supplemental Data 2,

Supplemental Data 3,

Supplemental Data 4

G. von Maltzahn, Park, J. - H., Agrawal, A., Bandaru, N. Kishor, Das, S. K., Sailor, M. J., and Bhatia, S. N., “Computationally guided photothermal tumor therapy using long-circulating gold nanorod antennas.”, Cancer Res, vol. 69, no. 9, pp. 3892-900, 2009.

Full Text + Supporting Information

J. - H. Park, von Maltzahn, G., Zhang, L., Derfus, A. M., Simberg, D., Harris, T. J., Ruoslahti, E., Bhatia, S. N., and Sailor, M. J., “Systematic surface engineering of magnetic nanoworms for in vivo tumor targeting.”, Small, vol. 5, no. 6, pp. 694-700, 2009.

Full Text + Supporting Information

J. - H. Park, Gu, L., von Maltzahn, G., Ruoslahti, E., Bhatia, S. N., and Sailor, M. J., “Biodegradable luminescent porous silicon nanoparticles for in vivo applications.”, Nat Mater, vol. 8, no. 4, pp. 331-6, 2009.

Full Text + Supporting Information

J. M. Higgins, Eddington, D. T., Bhatia, S. N., and Mahadevan, L., “Statistical dynamics of flowing red blood cells by morphological image processing.”, PLoS Comput Biol, vol. 5, no. 2, p. e1000288, 2009.

Full Text

A. A. Chen, Khetani, S. R., Lee, S., Bhatia, S. N., and Van Vliet, K. J., “Modulation of hepatocyte phenotype in vitro via chemomechanical tuning of polyelectrolyte multilayers.”, Biomaterials, vol. 30, no. 6, pp. 1113-20, 2009.

Full Text + Supporting Information

S. D. Alvarez, Derfus, A. M., Schwartz, M. P., Bhatia, S. N., and Sailor, M. J., “The compatibility of hepatocytes with chemically modified porous silicon with reference to in vitro biosensors.”, Biomaterials, vol. 30, no. 1, pp. 26-34, 2009.

Full Text

2008

J. - H. Park, von Maltzahn, G., Ruoslahti, E., Bhatia, S. N., and Sailor, M. J., “Micellar hybrid nanoparticles for simultaneous magnetofluorescent imaging and drug delivery.”, Angew Chem Int Ed Engl, vol. 47, no. 38, pp. 7284-8, 2008.

Full Text,

Supporting Information

T. J. Harris, von Maltzahn, G., Lord, M. E., Park, J. - H., Agrawal, A., Min, D. - H., Sailor, M. J., and Bhatia, S. N., “Protease-triggered unveiling of bioactive nanoparticles.”, Small, vol. 4, no. 9, pp. 1307-12, 2008.

Full Text,

Supporting Information

S. R. Khetani, Chen, A. A., Ranscht, B., and Bhatia, S. N., “T-cadherin modulates hepatocyte functions in vitro.”, FASEB J, vol. 22, no. 11, pp. 3768-75, 2008.

Full Text,

Supporting Information

G. von Maltzahn, Ren, Y., Park, J. - H., Min, D. - H., Kotamraju, V. Ramana, Jayakumar, J., Fogal, V., Sailor, M. J., Ruoslahti, E., and Bhatia, S. N., “In vivo tumor cell targeting with "click" nanoparticles.”, Bioconjug Chem, vol. 19, no. 8, pp. 1570-8, 2008.

Full Text,

Supporting Information

J. - H. Park, von Maltzahn, G., Zhang, L., Schwartz, M. P., Ruoslahti, E., Bhatia, S. N., and Sailor, M. J., “Magnetic Iron Oxide Nanoworms for Tumor Targeting and Imaging.”, Adv Mater, vol. 20, no. 9, pp. 1630-1635, 2008.

Full Text

C. J. Flaim, Teng, D., Chien, S., and Bhatia, S. N., “Combinatorial signaling microenvironments for studying stem cell fate.”, Stem Cells Dev, vol. 17, no. 1, pp. 29-39, 2008.

Full Text

S. R. Khetani and Bhatia, S. N., “Microscale culture of human liver cells for drug development.”, Nat Biotechnol, vol. 26, no. 1, pp. 120-6, 2008.

Full Text + Supplement

2007

G. von Maltzahn, Min, D. - H., Zhang, Y., Park, J. - H., Harris, T. J., Sailor, M. J., and Bhatia, S. N., “Nanoparticle Self-Assembly Directed by Antagonistic Kinase and Phosphatase Activities”, Advanced Materials, vol. 19, no. 21, pp. 3579–3583, 2007.

Full Text

J. M. Higgins, Eddington, D. T., Bhatia, S. N., and Mahadevan, L., “Sickle cell vasoocclusion and rescue in a microfluidic device.”, Proc Natl Acad Sci U S A, vol. 104, no. 51, pp. 20496-500, 2007.

Higgins_PNAS_2007.pdf

A. M. Derfus, von Maltzahn, G., Harris, T. J., Duza, T., Vecchio, K. S., Ruoslahti, E., and Bhatia, S. N., “Remotely Triggered Release from Magnetic Nanoparticles”, Advanced Materials, vol. 19, no. 22, pp. 3932–3936, 2007.

Full Text

E. E. Hui and Bhatia, S. N., “Silicon microchips for manipulating cell-cell interaction.”, J Vis Exp, no. 7, p. 268, 2007.

Full Text

G. H. Underhill and Bhatia, S. N., “High-throughput analysis of signals regulating stem cell fate and function.”, Curr Opin Chem Biol, vol. 11, no. 4, pp. 357-66, 2007.

Full Text

A. M. Derfus, Chen, A. A., Min, D. - H., Ruoslahti, E., and Bhatia, S. N., “Targeted quantum dot conjugates for siRNA delivery.”, Bioconjug Chem, vol. 18, no. 5, pp. 1391-6, 2007.

Full Text

A. R. Evans, Euteneuer, S., Chavez, E., Mullen, L. M., Hui, E. E., Bhatia, S. N., and Ryan, A. F., “Laminin and fibronectin modulate inner ear spiral ganglion neurite outgrowth in an in vitro alternate choice assay.”, Dev Neurobiol, vol. 67, no. 13, pp. 1721-30, 2007.

Full Text

D. R. Albrecht, Underhill, G. H., Mendelson, A., and Bhatia, S. N., “Multiphase electropatterning of cells and biomaterials.”, Lab Chip, vol. 7, no. 6, pp. 702-9, 2007.

Full Text

G. von Maltzahn, Harris, T. J., Park, J. - H., Min, D. - H., Schmidt, A. J., Sailor, M. J., and Bhatia, S. N., “Nanoparticle self-assembly gated by logical proteolytic triggers.”, J Am Chem Soc, vol. 129, no. 19, pp. 6064-5, 2007.

Full Text,

Supporting Information

E. E. Hui and Bhatia, S. N., “Micromechanical control of cell-cell interactions.”, Proc Natl Acad Sci U S A, vol. 104, no. 14, pp. 5722-6, 2007.

Full Text + Supplement

E. E. Hui and Bhatia, S. N., “Microscale control of cell contact and spacing via three-component surface patterning.”, Langmuir, vol. 23, no. 8, pp. 4103-7, 2007.

Full Text

D. Simberg, Duza, T., Park, J. Ho, Essler, M., Pilch, J., Zhang, L., Derfus, A. M., Yang, M., Hoffman, R. M., Bhatia, S. N., Sailor, M. J., and Ruoslahti, E., “Biomimetic amplification of nanoparticle homing to tumors.”, Proc Natl Acad Sci U S A, vol. 104, no. 3, pp. 932-6, 2007.

Full Text

V. Liu Tsang, Chen, A. A., Cho, L. M., Jadin, K. D., Sah, R. L., DeLong, S., West, J. L., and Bhatia, S. N., “Fabrication of 3D hepatic tissues by additive photopatterning of cellular hydrogels.”, FASEB J, vol. 21, no. 3, pp. 790-801, 2007.

Full Text,

Supporting Information1,

Supporting Information2

V. Liu Tsang and Bhatia, S. N., “Fabrication of three-dimensional tissues.”, Adv Biochem Eng Biotechnol, vol. 103, pp. 189-205, 2007.

G. H. Underhill, Chen, A. A., Albrecht, D. R., and Bhatia, S. N., “Assessment of hepatocellular function within PEG hydrogels.”, Biomaterials, vol. 28, no. 2, pp. 256-70, 2007.

Full Text

2006

J. W. Allen, Khetani, S. R., Johnson, R. S., and Bhatia, S. N., “In vitro liver tissue model established from transgenic mice: role of HIF-1alpha on hypoxic gene expression.”, Tissue Eng, vol. 12, no. 11, pp. 3135-47, 2006.

Full Text

S. R. Khetani and Bhatia, S. N., “Engineering tissues for in vitro applications.”, Curr Opin Biotechnol, vol. 17, no. 5, pp. 524-31, 2006.

Full Text

M. P. Schwartz, Derfus, A. M., Alvarez, S. D., Bhatia, S. N., and Sailor, M. J., “The smart Petri dish: a nanostructured photonic crystal for real-time monitoring of living cells.”, Langmuir, vol. 22, no. 16, pp. 7084-90, 2006.

Full Text

J. - H. Park, Derfus, A. M., Segal, E., Vecchio, K. S., Bhatia, S. N., and Sailor, M. J., “Local heating of discrete droplets using magnetic porous silicon-based photonic crystals.”, J Am Chem Soc, vol. 128, no. 24, pp. 7938-46, 2006.

Full Text

T. J. Harris, von Maltzahn, G., Derfus, A. M., Ruoslahti, E., and Bhatia, S. N., “Proteolytic actuation of nanoparticle self-assembly.”, Angew Chem Int Ed Engl, vol. 45, no. 19, pp. 3161-5, 2006.

Full Text

D. R. Albrecht, Underhill, G. H., Wassermann, T. B., Sah, R. L., and Bhatia, S. N., “Probing the role of multicellular organization in three-dimensional microenvironments.”, Nat Methods, vol. 3, no. 5, pp. 369-75, 2006.

Full Text + Supplement

2005

A. A. Chen, Derfus, A. M., Khetani, S. R., and Bhatia, S. N., “Quantum dots to monitor RNAi delivery and improve gene silencing.”, Nucleic Acids Res, vol. 33, no. 22, p. e190, 2005.

Full Text

C. J. Flaim, Chien, S., and Bhatia, S. N., “An extracellular matrix microarray for probing cellular differentiation.”, Nat Methods, vol. 2, no. 2, pp. 119-25, 2005.

Full Text,

Supporting Information

D. R. Albrecht, Tsang, V. Liu, Sah, R. L., and Bhatia, S. N., “Photo- and electropatterning of hydrogel-encapsulated living cell arrays.”, Lab Chip, vol. 5, no. 1, pp. 111-8, 2005.

Full Text

J. W. Allen, Khetani, S. R., and Bhatia, S. N., “In vitro zonation and toxicity in a hepatocyte bioreactor.”, Toxicol Sci, vol. 84, no. 1, pp. 110-9, 2005.

Full Text

J. W. Allen, Johnson, R. S., and Bhatia, S. N., “Hypoxic inhibition of 3-methylcholanthrene-induced CYP1A1 expression is independent of HIF-1alpha.”, Toxicol Lett, vol. 155, no. 1, pp. 151-9, 2005.

Full Text

2004

A. M. Derfus, Chan, W. C. W., and Bhatia, S. N., “Intracellular Delivery of Quantum Dots for Live Cell Labeling and Organelle Tracking”, Advanced Materials, vol. 16, pp. 961–966, 2004.

Full Text

A. M. Derfus, Chan, W. C. W., and Bhatia, S. N., “Probing the Cytotoxicity of Semiconductor Quantum Dots”, Nano Letters, vol. 4, pp. 11-18, 2004.

Full Text

J. R. Dorvee, Derfus, A. M., Bhatia, S. N., and Sailor, M. J., “Manipulation of liquid droplets using amphiphilic, magnetic one-dimensional photonic crystal chaperones.”, Nat Mater, vol. 3, no. 12, pp. 896-9, 2004.

Full Text

V. I. Chin, Taupin, P., Sanga, S., Scheel, J., Gage, F. H., and Bhatia, S. N., “Microfabricated platform for studying stem cell fates.”, Biotechnol Bioeng, vol. 88, no. 3, pp. 399-415, 2004.

Full Text

D. R. Albrecht, Sah, R. L., and Bhatia, S. N., “Geometric and material determinants of patterning efficiency by dielectrophoresis.”, Biophys J, vol. 87, no. 4, pp. 2131-47, 2004.

Full Text

P. Lin, Chan, W. C. W., Badylak, S. F., and Bhatia, S. N., “Assessing porcine liver-derived biomatrix for hepatic tissue engineering.”, Tissue Eng, vol. 10, no. 7-8, pp. 1046-53, 2004.

Full Text

V. Liu Tsang and Bhatia, S. N., “Three-dimensional tissue fabrication.”, Adv Drug Deliv Rev, vol. 56, no. 11, pp. 1635-47, 2004.

Full Text

S. R. Khetani, Szulgit, G., Del Rio, J. A., Barlow, C., and Bhatia, S. N., “Exploring interactions between rat hepatocytes and nonparenchymal cells using gene expression profiling.”, Hepatology, vol. 40, no. 3, pp. 545-54, 2004.

Full Text

2003

G. Vozzi, Flaim, C., Ahluwalia, A., and Bhatia, S. N., “Fabrication of PLGA scaffolds using soft lithography and microsyringe deposition.”, Biomaterials, vol. 24, no. 14, pp. 2533-40, 2003.

Full Text

Y. Yang Li, Cunin, F., Link, J. R., Gao, T., Betts, R. E., Reiver, S. H., Chin, V., Bhatia, S. N., and Sailor, M. J., “Polymer replicas of photonic porous silicon for sensing and drug delivery applications.”, Science, vol. 299, no. 5615, pp. 2045-7, 2003.

Full Text

J. W. Allen and Bhatia, S. N., “Formation of steady-state oxygen gradients in vitro: application to liver zonation.”, Biotechnol Bioeng, vol. 82, no. 3, pp. 253-62, 2003.

Full Text

S. M. Gopalan, Flaim, C., Bhatia, S. N., Hoshijima, M., Knoell, R., Chien, K. R., Omens, J. H., and McCulloch, A. D., “Anisotropic stretch-induced hypertrophy in neonatal ventricular myocytes micropatterned on deformable elastomers.”, Biotechnol Bioeng, vol. 81, no. 5, pp. 578-87, 2003.

Full Text

2002

V. A. Liu and Bhatia, S. N., “Three-Dimensional Photopatterning of Hydrogels Containing Living Cells”, Biomedical Microdevices, vol. 4, no. 4, pp. 257 - 266, 2002.

Full Text

M. Ozkan, Pisanic, T., Scheel, J., Barlow, C., Esener, S., and Bhatia, S. N., “Electro-Optical Platform for the Manipulation of Live Cells”, Langmuir, vol. 19, no. 5, pp. 1532 - 1538, 2002.

Full Text

M. Ozkan, Bhatia, S. N., and Esener, S., “Optical Addressing of Polymer Beads for Chip-Based Systems”, Sensors and Materials, vol. 14, pp. 189–197, 2002.

Ozkan2002_SensorsMat.pdf

G. D. Heyman, Martyna, B., and Bhatia, S. N., “Gender and achievement-related beliefs among engineering students”, Journal of Women and Minorities in Science and Engineering, vol. 8, pp. 41–52, 2002.

Full Text

G. Vozzi, Flaim, C. J., Bianchi, F., Ahluwalia, A., and Bhatia, S. N., “Microfabricated PLGA scaffolds: a comparative study for application to tissue engineering”, Materials Science and Engineering: C, vol. 20, no. 1-2, pp. 43 - 47, 2002.

Full Text

F. Cunin, Schmedake, T. A., Link, J. R., Li, Y. Yang, Koh, J., Bhatia, S. N., and Sailor, M. J., “Biomolecular screening with encoded porous-silicon photonic crystals.”, Nat Mater, vol. 1, no. 1, pp. 39-41, 2002.

Full Text

J. W. Allen and Bhatia, S. N., “Improving the next generation of bioartificial liver devices.”, Semin Cell Dev Biol, vol. 13, no. 6, pp. 447-54, 2002.

Full Text

J. W. Allen and Bhatia, S. N., “Engineering liver therapies for the future.”, Tissue Eng, vol. 8, no. 5, pp. 725-37, 2002.

Full Text

M. E. Akerman, Chan, W. C. W., Laakkonen, P., Bhatia, S. N., and Ruoslahti, E., “Nanocrystal targeting in vivo.”, Proc Natl Acad Sci U S A, vol. 99, no. 20, pp. 12617-21, 2002.

Full Text

V. A. Liu, Jastromb, W. E., and Bhatia, S. N., “Engineering protein and cell adhesivity using PEO-terminated triblock polymers.”, J Biomed Mater Res, vol. 60, no. 1, pp. 126-34, 2002.

Full Text

2001

M. Ozkan, Ozkan, C. S., Kibar, O., Wang, M. M., Bhatia, S. N., and Esener, S., “Heterogeneous integration through electrokinetic migration”, Engineering in Medicine and Biology Magazine, IEEE, vol. 20, no. 6, pp. 144-151, 2001.

Full Text

M. Ozkan, Esener, S., and Bhatia, S. N., “Electrokinetic Assembly of Microsphere and Cellular Arrays”, Symposia LL/MM/NN/OO – Biomaterials for Drug Delivery & Tissue Engineering, 2001.

Full Text

V. Chin, Collins, B. E., Sailor, M. J., and Bhatia, S. N., “Compatibility of Primary Hepatocytes with Oxidized Nanoporous Silicon”, Advanced Materials, vol. 13, pp. 1877–1880, 2001.

Full Text

J. W. Allen, Hassanein, T., and Bhatia, S. N., “Advances in bioartificial liver devices.”, Hepatology, vol. 34, no. 3, pp. 447-55, 2001.

Full Text

S. Li, Bhatia, S. N., Hu, Y. L., Shiu, Y. T., Li, Y. S., Usami, S., and Chien, S., “Effects of morphological patterning on endothelial cell migration.”, Biorheology, vol. 38, no. 2-3, pp. 101-8, 2001.

Full Text

2000

K. Behnia, Bhatia, S. N., Jastromb, N., Balis, U., Sullivan, S., Yarmush, M., and Toner, M., “Xenobiotic metabolism by cultured primary porcine hepatocytes.”, Tissue Eng, vol. 6, no. 5, pp. 467-79, 2000.

Full Text

1999

S. N. Bhatia and Chen, C. S., “Tissue Engineering at the Micro-Scale”, Biomedical Microdevices, vol. 2, pp. 131-144, 1999.

Full Text

S. N. Bhatia, Balis, U. J., Yarmush, M. L., and Toner, M., “Effect of cell-cell interactions in preservation of cellular phenotype: cocultivation of hepatocytes and nonparenchymal cells.”, FASEB J, vol. 13, no. 14, pp. 1883-900, 1999.

Full Text

S. N. Bhatia, Suri, V., Bundy, A., and Krauss, C. M., “Prenatal detection and mapping of a distal 8p deletion associated with congenital heart disease.”, Prenat Diagn, vol. 19, no. 9, pp. 863-7, 1999.

Full Text

U. J. Balis, Behnia, K., Dwarakanath, B., Bhatia, S. N., Sullivan, S. J., Yarmush, M. L., and Toner, M., “Oxygen consumption characteristics of porcine hepatocytes.”, Metab Eng, vol. 1, no. 1, pp. 49-62, 1999.

Full Text

G. A. Ledezma, Folch, A., Bhatia, S. N., Balis, U. J., Yarmush, M. L., and Toner, M., “Numerical model of fluid flow and oxygen transport in a radial-flow microchannel containing hepatocytes.”, J Biomech Eng, vol. 121, no. 1, pp. 58-64, 1999.

Full Text

1998

S. N. Bhatia, Balis, U. J., Yarmush, M. L., and Toner, M., “Probing heterotypic cell interactions: hepatocyte function in microfabricated co-cultures.”, J Biomater Sci Polym Ed, vol. 9, no. 11, pp. 1137-60, 1998.

Full Text

S. N. Bhatia, Balis, U. J., Yarmush, M. L., and Toner, M., “Microfabrication of hepatocyte/fibroblast co-cultures: role of homotypic cell interactions.”, Biotechnol Prog, vol. 14, no. 3, pp. 378-87, 1998.

Full Text

1997

S. N. Bhatia, Yarmush, M. L., and Toner, M., “Engineered substrates for controlling cell-cell interactions”, Advances in Heat and Mass Transfer in Biotechnology, vol. ASME HTD-355, no. BED-37, pp. 99-103, 1997.

Full Text

S. N. Bhatia, Yarmush, M. L., and Toner, M., “Controlling cell interactions by micropatterning in co-cultures: hepatocytes and 3T3 fibroblasts.”, J Biomed Mater Res, vol. 34, no. 2, pp. 189-99, 1997.

Full Text

1996

S. N. Bhatia, Toner, M., Foy, B. D., Rotem, A., Tompkins, R. G., and Yarmush, M. L., “Zonal liver cell heterogeneity: effects of oxygen on metabolic functions of hepatocytes”, J Cell Eng, vol. 1, pp. 125-135, 1996.

Full Text

1994

S. N. Bhatia, Toner, M., Tompkins, R. G., and Yarmush, M. L., “Selective Adhesion of Hepatocytes on Patterned Surfaces”, Annals of the New York Academy of Sciences, vol. 745, no. 1204, pp. 187 - 209, 1994.

Full Text

A. Rotem, Toner, M., Bhatia, S. N., Foy, B. D., Tompkins, R. G., and Yarmush, M. L., “Oxygen is a factor determining in vitro tissue assembly: Effects on attachment and spreading of hepatocytes.”, Biotechnol Bioeng, vol. 43, no. 7, pp. 654-60, 1994.

Full Text