Publications


2017

N. Lippok, Villiger, M., Albanese, A., Meijer, E. F. J., Chung, K., Padera, T. P., Bhatia, S. N., and Bouma, B. E., “Depolarization signatures map gold nanorods within biological tissue”, Nature Photonics, 2017. PDF icon Manuscript
K. R. Stevens, Scull, M. A., Ramanan, V., Fortin, C. L., Chaturvedi, R. R., Knouse, K. A., Xiao, J. W., Fung, C., Mirabella, T., Chen, A. X., McCue, M. G., Yang, M. T., Fleming, H. E., Chung, K., de Jong, Y. P., Chen, C. S., Rice, C. M., and Bhatia, S. N., “In situ expansion of engineered human liver tissue in a mouse model of chronic liver disease”, Science Translational Medicine, vol. 9, no. 399, 2017.
E. J. Kwon, Skalak, M., Bertucci, A., Braun, G., Ricci, F., Ruoslahti, E., Sailor, M. J., and Bhatia, S. N., “Porous Silicon Nanoparticle Delivery of Tandem Peptide Anti-Infectives for the Treatment of Pseudomonas aeruginosa Lung Infections”, Advanced Materials, 2017. PDF icon Manuscript
E. J. Kwon†, Dudani, J. S. †, and Bhatia, S. N., “Ultrasensitive tumour-penetrating nanosensors of protease activity”, Nature Biomedical Engineering, vol. 1, p. 0054, 2017. PDF icon Full Text, PDF icon Supporting Information
S. Ng, March, S., Galstian, A., Gural, N., Stevens, K. R., Mota, M. M., and Bhatia, S. N., “Towards a Humanized Mouse Model of Liver Stage Malaria Using Ectopic Artificial Livers”, Scientific Reports, vol. 7, no. 45424, 2017. PDF icon Full Text, PDF icon Supporting Information


2016

S. Schuerle†, Dudani, J. S. †, Christiansen, M. G., Anikeeva, P., and Bhatia, S. N., “Magnetically Actuated Protease Sensors for in Vivo Tumor Profiling”, Nano Letters, vol. 16, no. 10, pp. 6303–6310, 2016. PDF icon Full Text + Supporting Information
J. H. Lo†, Kwon, E. J. †, Zhang, A. Q., Singhal, P., and Bhatia, S. N., “Comparison of Modular PEG Incorporation Strategies for Stabilization of Peptide–siRNA Nanocomplexes”, Bioconjugate Chemistry, vol. 27, no. 10, pp. 2323-2331, 2016. PDF icon Full Text + Supporting Information
N. Kato, Comer, E., Sakata-Kato, T., Sharma, A., Sharma, M., Maetani, M., Bastien, J., Brancucci, N. M., Bittker, J. A., Corey, V., Clarke, D., Derbyshire, E. R., Dornan, G., Duffy, S., Eckley, S., Itoe, M. A., Koolen, K. M. J., Lewis, T. A., Lui, P. S., Lukens, A. K., Lund, E., March, S., Meibalan, E., Meier, B. C., McPhail, J., Mitasev, B., Moss, E. L., Sayes, M., VanGessel, Y., Wawer, M. J., Yoshinaga, T., Zeeman, A. - M., Avery, V. M., Bhatia, S. N., Burke, J. E., Catteruccia, F., Clardy, J. C., Clemons, P. A., Dechering, K. J., Duvall, J. R., Foley, M. A., Gusovsky, F., Kocken, C. H. M., Marti, M., Morningstar, M. L., Munoz, B., Neafsey, D. E., Sharma, A., Winzeler, E. A., Wirth, D. F., Scherer, C. A., and Schreiber, S. L., “Diversity-oriented synthesis yields novel multistage antimalarial inhibitors”, Nature, vol. 538, no. 7625, pp. 344-349, 2016. PDF icon Full Text + Supporting Information
M. T. Grilo Ruivo, Vera, I. Medina, Sales-Dias, J., Meireles, P., Gural, N., Bhatia, S. N., Mota, M. M., and Mancio-Silva, L., “Host AMPK Is a Modulator of Plasmodium Liver Infection.”, Cell Rep, vol. 16, no. 10, pp. 2539-45, 2016. PDF icon Full Text + Supporting Information
K. Shaw-Saliba, Clarke, D., Santos, J. M., Menezes, M. José, Lim, C., Mascarenhas, A., Chery, L., Gomes, E., March, S., Bhatia, S. N., Rathod, P. K., Ferreira, M. U., Catteruccia, F., and Duraisingh, M. T., “Infection of laboratory colonies of Anopheles mosquitoes with Plasmodium vivax from cryopreserved clinical isolates.”, Int J Parasitol, vol. 46, no. 11, pp. 679-683, 2016. PDF icon Full Text
P. K. Jain, Ramanan, V., Schepers, A. G., Dalvie, N. S., Panda, A., Fleming, H. E., and Bhatia, S. N., “Development of Light-Activated CRISPR Using Guide RNAs with Photocleavable Protectors”, Angewandte Chemie International Edition, vol. 55, no. 40, pp. 12440–12444, 2016. PDF icon Full Text + Supporting Information
W. C. Van Voorhis, Adams, J. H., Adelfio, R., Ahyong, V., Akabas, M. H., Alano, P., Alday, A., Resto, Yán, Alsibaee, A., Alzualde, A., Andrews, K. T., Avery, S. V., Avery, V. M., Ayong, L., Baker, M., Baker, S., Ben Mamoun, C., Bhatia, S., Bickle, Q., Bounaadja, L., Bowling, T., Bosch, ürgen, Boucher, L. E., Boyom, F. F., Brea, J., Brennan, M., Burton, A., Caffrey, C. R., Camarda, G., Carrasquilla, M., Carter, D., Cassera, M. Belen, Cheng, K. Chih- Chien, Chindaudomsate, W., Chubb, A., Colon, B. L., n-López, D. D. ó, Corbett, Y., Crowther, G. J., Cowan, N., Alessandro, S. ’, Le Dang, N., Delves, M., DeRisi, J. L., Du, A. Y., Duffy, S., El-Sayed, S. Abd El- Sal, Ferdig, M. T., Robledo, éA. ández, Fidock, D. A., Florent, I., Fokou, P. V. T., Galstian, A., Gamo, F. Javier, Gokool, S., Gold, B., Golub, T., Goldgof, G. M., Guha, R., W. Guiguemde, A., Gural, N., R. Guy, K., Hansen, M. A. E., Hanson, K. K., Hemphill, A., van Huijsduijnen, R. Hooft, Horii, T., Horrocks, P., Hughes, T. B., Huston, C., Igarashi, I., Ingram-Sieber, K., Itoe, M. A., Jadhav, A., Jensen, A. Naranuntar, Jensen, L. T., Jiang, R. H. Y., Kaiser, A., Keiser, J., Ketas, T., Kicka, S., Kim, S., Kirk, K., Kumar, V. P., Kyle, D. E., Lafuente, M. Jose, Landfear, S., Lee, N., Lee, S., Lehane, A. M., Li, F., Little, D., Liu, L., s, Má, Loza, M. I., Lubar, A., Lucantoni, L., Lucet, I., Maes, L., Mancama, D., Mansour, N. R., March, S., McGowan, S., Vera, I. Medina, Meister, S., Mercer, L., Mestres, J., Mfopa, A. N., Misra, R. N., Moon, S., Moore, J. P., da Costa, F. Morais Rod, ller, Jü, Muriana, A., Hewitt, S. Nakazawa, Nare, B., Nathan, C., Narraidoo, N., Nawaratna, S., Ojo, K. K., Ortiz, D., Panic, G., Papadatos, G., Parapini, S., Patra, K., Pham, N., Prats, S., Plouffe, D. M., Poulsen, S. - A., Pradhan, A., Quevedo, C., Quinn, R. J., Rice, C. A., Rizk, M. Abdo, Ruecker, A., Onge, R. St., Ferreira, R. Salgado, Samra, J., Robinett, N. G., Schlecht, U., Schmitt, M., Villela, F. Silva, Silvestrini, F., Sinden, R., Smith, D. A., Soldati, T., ller, Aü, Stamm, S. Maximilian, Sullivan, D. J., Sullivan, W., Suresh, S., Suzuki, B. M., Suzuki, Y., S. Swamidass, J., Taramelli, D., Tchokouaha, L. R. Y., Theron, A., Thomas, D., Tonissen, K. F., Townson, S., Tripathi, A. K., Trofimov, V., Udenze, K. O., Ullah, I., Vallieres, C., Vigil, E., Vinetz, J. M., Vinh, P. Voong, Vu, H., Watanabe, N. -aki, Weatherby, K., White, P. M., Wilks, A. F., Winzeler, E. A., Wojcik, E., Wree, M., Wu, W., Yokoyama, N., Zollo, P. H. A., Abla, N., Blasco, B., Burrows, J., Laleu, ît, Leroy, D., Spangenberg, T., Wells, T., and Willis, P. A., “Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond”, PLOS Pathogens, vol. 12, no. 7, 2016. PDF icon Full Text
E. J. Kwon, Skalak, M., Bu, R. Lo, and Bhatia, S. N., “Neuron-Targeted Nanoparticle for siRNA Delivery to Traumatic Brain Injuries”, ACS Nano, vol. 10, no. 8, pp. 7926–7933, 2016. PDF icon Full Text + Supporting Information
O. M. Din†, Danino, T. †, Prindle, A., Skalak, M., Selimkhanov, J., Allen, K., Julio, E., Atolia, E., Tsimring, L. S., Bhatia, S. N. ‡, and Hasty, J. ‡, “Synchronized cycles of bacterial lysis for in vivo delivery”, Nature, vol. 536, no. 7614, pp. 81-85, 2016. PDF icon Full Text + Supporting Information
A. P. Mann, Scodeller, P., Hussain, S., Joo, J., Kwon, E., Braun, G. B., Mölder, T., She, Z. - G., Kotamraju, V. Ramana, Ranscht, B., Krajewski, S., Teesalu, T., Bhatia, S., Sailor, M. J., and Ruoslahti, E., “A peptide for targeted, systemic delivery of imaging and therapeutic compounds into acute brain injuries.”, Nat Commun, vol. 7, p. 11980, 2016. PDF icon Full Text + Supporting Information
J. Kang, Joo, J., Kwon, E. J., Skalak, M., Hussain, S., She, Z. - G., Ruoslahti, E., Bhatia, S. N., and Sailor, M. J., “Self-Sealing Porous Silicon-Calcium Silicate Core-Shell Nanoparticles for Targeted siRNA Delivery to the Injured Brain”, Advanced Materials, vol. 28, no. 36, pp. 7962–7969, 2016. PDF icon Full Text + Supporting Information
A. Schepers, Li, C., Chhabra, A., Seney, B. Tschudy, and Bhatia, S., “Engineering a perfusable 3D human liver platform from iPS cells”, Lab Chip, vol. 16, pp. 2644-2653, 2016. PDF icon Full Text + Supporting Information
J. Joo, Kwon, E. J., Kang, J., Skalak, M., Anglin, E. J., Mann, A. P., Ruoslahti, E., Bhatia, S. N., and Sailor, M. J., “Porous silicon–graphene oxide core–shell nanoparticles for targeted delivery of siRNA to the injured brain”, Nanoscale Horiz., vol. 1, no. 5, pp. 407 - 414, 2016. PDF icon Full Text + Supporting Information
J. Shan, Logan, D. J., Root, D. E., Carpenter, A. E., and Bhatia, S. N., “High-Throughput Platform for Identifying Molecular Factors Involved in Phenotypic Stabilization of Primary Human Hepatocytes In Vitro”, Journal of Biomolecular Screening, pp. 1-15, 2016. PDF icon Full Text
V. Ramanan, Trehan, K., Ong, M. - L., Luna, J. M., Hoffmann, H. - H., Espiritu, C., Sheahan, T. P., Chandrasekar, H., Schwartz, R. E., Christine, K. S., Rice, C. M., van Oudenaarden, A., and Bhatia, S. N., “Viral genome imaging of hepatitis C virus to probe heterogeneous viral infection and responses to antiviral therapies”, Virology, vol. 494, pp. 236 - 247, 2016. PDF icon Full Text
J. S. Dudani, Buss, C. G., Akana, R. T. K., Kwong, G. A., and Bhatia, S. N., “Sustained-Release Synthetic Biomarkers for Monitoring Thrombosis and Inflammation Using Point-of-Care Compatible Readouts”, Advanced Functional Materials, vol. 26, no. 17, pp. 2919-2928, 2016. PDF icon Full Text + Supporting Information
I. Amit, Baker, D., Barker, R., Berger, B., Bertozzi, C., Bhatia, S., Biffi, A., Demichelis, F., Doudna, J., Dowdy, S. F., Endy, D., Helmstaedter, M., Junca, H., June, C., Kamb, S., Khvorova, A., Kim, D. -hyeong, Kim, J. - S., Krishnan, Y., Lakadamyali, M., Lappalainen, T., Lewin, S., Liao, J., Loman, N., Lundberg, E., Lynd, L., Martin, C., Mellman, I., Miyawaki, A., Mummery, C., Nelson, K., Paz, J., Peralta-Yahya, P., Picotti, P., Polyak, K., Prather, K., Qin, J., Quake, S., Regev, iv, A., Rogers, J. A., Shetty, R., Sommer, M., Stevens, M., Stolovitzky, G., Takahashi, M., Tang, F., Teichmann, S., Torres-Padilla, M. - E., Tripathi, L., Vemula, P., Verdine, G., Vollmer, F., Wang, J., Ying, J. Y., Zhang, F., and Zhang, T., “Voices of biotech”, Nature Biotechnology, vol. 34, no. 3, pp. 270 - 275, 2016. PDF icon Full Text
D. J. Logan, Shan, J., Bhatia, S. N., and Carpenter, A. E., “Quantifying co-cultured cell phenotypes in high-throughput using pixel-based classification.”, Methods, vol. 96, pp. 6-11, 2016. PDF icon Full Text
D. F. Braga Malta, Reticker-Flynn, N. E., da Silva, C. L., Cabral, J. M. S., Fleming, H. E., Zaret, K. S., Bhatia, S. N., and Underhill, G. H., “Extracellular matrix microarrays to study inductive signaling for endoderm specification.”, Acta Biomater, 2016. PDF icon Full Text + Supporting Information


2015

J. S. Dudani, Jain, P. K., Kwong, G. A., Stevens, K. R., and Bhatia, S. N., “Photoactivated Spatiotemporally-Responsive Nanosensors of in Vivo Protease Activity.”, ACS Nano, vol. 9, no. 12, pp. 11708-17, 2015. PDF icon Full Text + Supporting Information
E. J. Kwon, Lo, J. H., and Bhatia, S. N., “Smart nanosystems: Bio-inspired technologies that interact with the host environment.”, Proc Natl Acad Sci U S A, vol. 112, no. 47, pp. 14460-6, 2015. PDF icon Full Text
S. March, Ramanan, V., Trehan, K., Ng, S., Galstian, A., Gural, N., Scull, M. A., Shlomai, A., Mota, M. M., Fleming, H. E., Khetani, S. R., Rice, C. M., and Bhatia, S. N., “Micropatterned coculture of primary human hepatocytes and supportive cells for the study of hepatotropic pathogens”, Nat. Protocols, vol. 10, no. 12, pp. 2027 - 2053, 2015. PDF icon PDF Full Text
G. A. Kwong, Dudani, J. S., Carrodeguas, E., Mazumdar, E. V., Zekavat, S. M., and Bhatia, S. N., “Mathematical framework for activity-based cancer biomarkers”, Proceedings of the National Academy of Sciences, 2015. PDF icon Full text + supporting information
A. F. Bagley, Scherz-Shouval, R., Galie, P. A., Zhang, A. Q., Wyckoff, J., Whitesell, L., Chen, C. S., Lindquist, S., and Bhatia, S. N., “Endothelial Thermotolerance Impairs Nanoparticle Transport in Tumors.”, Cancer Res, vol. 75, no. 16, pp. 3255-67, 2015. PDF icon Full Text + Supporting Information
M. A. Phillips, Lotharius, J., Marsh, K., White, J., Dayan, A., White, K. L., Njoroge, J. W., Mazouni, F. El, Lao, Y., Kokkonda, S., Tomchick, D. R., Deng, X., Laird, T., Bhatia, S. N., March, S., Ng, C. L., Fidock, D. A., Wittlin, S., Lafuente-Monasterio, M., Benito, F. Javier Gam, Alonso, L. Maria Sanz, Martinez, M. Santos, Jimenez-Diaz, M. Belen, Bazaga, S. Ferrer, Angulo-Barturen, I., Haselden, J. N., Louttit, J., Cui, Y., Sridhar, A., Zeeman, A. - M., Kocken, C., Sauerwein, R., Dechering, K., Avery, V. M., Duffy, S., Delves, M., Sinden, R., Ruecker, A., Wickham, K. S., Rochford, R., Gahagen, J., Iyer, L., Riccio, E., Mirsalis, J., Bathhurst, I., Rueckle, T., Ding, X., Campo, B., Leroy, D., M. Rogers, J., Rathod, P. K., Burrows, J. N., and Charman, S. A., “A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malaria”, Science Translational Medicine, vol. 7, pp. 296ra111–296ra111, 2015. PDF icon PDF Full Text
V. Ramanan†, Shlomai, A. †, Cox†, D. B. T., Schwartz, R. E., Michailidis, E., Bhatta, A., Scott, D. A., Zhang, F. ‡, Rice, C. M. ‡, and Bhatia‡, S. N., “CRISPR/Cas9 cleavage of viral DNA efficiently suppresses hepatitis B virus”, Sci. Rep., vol. 5, 2015. PDF icon Full Text + Supporting Info
T. Danino†, Prindle, A. †, Kwong, G. A., Skalak, M., Li, H., Allen, K., Hasty, J. ‡, and Bhatia‡, S. N., “Programmable probiotics for detection of cancer in urine”, Science Translational Medicine, vol. 7, p. 289ra84–, 2015. PDF icon PDF Full Text + Supporting Info, PDF icon Recommended by Faculty of 1000
K. R. Stevens, Miller, J. S., Blakely, B. L., Chen, C. S., and Bhatia, S. N., “Degradable hydrogels derived from PEG-diacrylamide for hepatic tissue engineering.”, J Biomed Mater Res A, 2015. PDF icon PDF Full Text
R. R. Chaturvedi, Stevens, K. R., Solorzano, R. D., Schwartz, R. E., Eyckmans, J., Baranski, J. D., Stapleton, S. Chase, Bhatia, S. N., and Chen, C. S., “Patterning vascular networks in vivo for tissue engineering applications.”, Tissue Eng Part C Methods, vol. 21, no. 5, pp. 509-17, 2015. PDF icon Full Text + Supporting Information
S. Ng, Schwartz, R. E., March, S., Galstian, A., Gural, N., Shan, J., Prabhu, M., Mota, M. M., and Bhatia, S. N., “Human iPSC-derived hepatocyte-like cells support Plasmodium liver-stage infection in vitro.”, Stem Cell Reports, vol. 4, no. 3, pp. 348-59, 2015. PDF icon Full Text + Supporting Info, PDF icon Highlighted in Nature Medicine
N. E. Reticker-Flynn and Bhatia, S. N., “Aberrant glycosylation promotes lung cancer metastasis through adhesion to galectins in the metastatic niche.”, Cancer Discov, vol. 5, no. 2, pp. 168-81, 2015. PDF icon (PDF Full Text + Supplement), PDF icon Featured in Nature, PDF icon Featured in Nature Reviews Cancer, PDF icon Featured in Cancer Discovery Features, PDF icon (Cover Feature)
K. K. Hanson, March, S., Ng, S., Bhatia, S. N., and Mota, M. M., “In vitro alterations do not reflect a requirement for host cell cycle progression during Plasmodium liver stage infection.”, Eukaryot Cell, vol. 14, no. 1, pp. 96-103, 2015. PDF icon Full Text + Supporting Info


2014

M. A. Itoe, Sampaio, J. L., Cabal, G. G., Real, E., Zuzarte-Luis, V., March, S., Bhatia, S. N., Frischknecht, F., Thiele, C., Shevchenko, A., and Mota, M. M., “Host cell phosphatidylcholine is a key mediator of malaria parasite survival during liver stage infection.”, Cell Host Microbe, vol. 16, no. 6, pp. 778-86, 2014. PDF icon Full Text + Supporting Information
K. Y. Lin, Kwon, E. J., Lo, J., and Bhatia, S. N., “Drug-induced amplification of nanoparticle targeting to tumors”, Nano Today, vol. 9, pp. 550 - 559, 2014. PDF icon Full Text + Supporting Info
A. D. Warren†, Gaylord†, S. T., Ngan, K. C., Milutinovic, M. Dumont, Kwong, G. A., Bhatia‡, S. N., and Walt‡, D. R., “Disease detection by ultrasensitive quantification of microdosed synthetic urinary biomarkers.”, J Am Chem Soc, vol. 136, no. 39, pp. 13709-14, 2014. PDF icon Full Text + Supporting Info
D. Ghosh†, Bagley†, A. F., Na, Y. Jeong, Birrer, M. J., Bhatia‡, S. N., and Belcher‡, A. M., “Deep, noninvasive imaging and surgical guidance of submillimeter tumors using targeted M13-stabilized single-walled carbon nanotubes.”, Proc Natl Acad Sci U S A, vol. 111, no. 38, pp. 13948-53, 2014. PDF icon Full Text + Supporting Info, PDF icon Featured in Chemical Research in Toxicology
V. Ramanan†, Scull, M. A. †, Sheahan, T. P., Rice‡, C. M., and Bhatia‡, S. N., “New Methods in Tissue Engineering: Improved Models for Viral Infection”, Annual Review of Virology, vol. 1, pp. 475-499, 2014. PDF icon Full Text
K. Y. Lin, Lo, J. H., Consul, N., Kwong, G. A., and Bhatia, S. N., “Self-titrating anticoagulant nanocomplexes that restore homeostatic regulation of the coagulation cascade.”, ACS Nano, vol. 8, no. 9, pp. 8776-85, 2014. PDF icon Full Text + Supporting Info
S. N. Bhatia and Ingber, D. E., “Microfluidic organs-on-chips.”, Nat Biotechnol, vol. 32, no. 8, pp. 760-72, 2014. PDF icon Full Text, PDF icon Related feature in Nature
A. Shlomai†, Schwartz†, R. E., Ramanan†, V., Bhatta, A., de Jong, Y. P., Bhatia‡, S. N., and Rice‡, C. M., “Modeling host interactions with hepatitis B virus using primary and induced pluripotent stem cell-derived hepatocellular systems.”, Proc Natl Acad Sci U S A, vol. 111, no. 33, pp. 12193-8, 2014. PDF icon Full Text + Supporting Info, PDF icon 'In This Issue' highlight
S. Hauert and Bhatia, S. N., “Mechanisms of cooperation in cancer nanomedicine: towards systems nanotechnology.”, Trends Biotechnol, vol. 32, no. 9, pp. 448-55, 2014. PDF icon Full Text
S. N. Bhatia, Underhill, G. H., Zaret, K. S., and Fox, I. J., “Cell and tissue engineering for liver disease.”, Sci Transl Med, vol. 6, no. 245, p. 245sr2, 2014. PDF icon Full Text
E. E. Hui, Li, C., Agrawal, A., and Bhatia, S. N., “Macro-to-Micro Interface for the Control of Cellular Organization”, Journal of Microelectromechanical Systems, vol. 23, pp. 391–397, 2014. PDF icon Full Text
A. D. Warren, Kwong, G. A., Wood, D. K., Lin, K. Y., and Bhatia, S. N., “Point-of-care diagnostics for noncommunicable diseases using synthetic urinary biomarkers and paper microfluidics.”, Proc Natl Acad Sci U S A, vol. 111, no. 10, pp. 3671-6, 2014. PDF icon Full Text + Supporting Info
C. Y. Li, Stevens, K. R., Schwartz, R. E., Alejandro, B. S., Huang, J. H., and Bhatia, S. N., “Micropatterned cell-cell interactions enable functional encapsulation of primary hepatocytes in hydrogel microtissues.”, Tissue Eng Part A, vol. 20, no. 15-16, pp. 2200-12, 2014. PDF icon Full Text
R. E. Schwartz, Fleming, H. E., Khetani, S. R., and Bhatia, S. N., “Pluripotent stem cell-derived hepatocyte-like cells.”, Biotechnol Adv, vol. 32, no. 2, pp. 504-13, 2014. PDF icon Full Text
S. Olcum, Cermak, N., Wasserman, S. C., Christine, K. S., Atsumi, H., Payer, K. R., Shen, W., Lee, J., Belcher, A. M., Bhatia, S. N., and Manalis, S. R., “Weighing nanoparticles in solution at the attogram scale.”, Proc Natl Acad Sci U S A, vol. 111, no. 4, pp. 1310-5, 2014. PDF icon Full Text + Supporting Info
S. Ng, March, S., Galstian, A., Hanson, K., Carvalho, T., Mota, M. M., and Bhatia, S. N., “Hypoxia promotes liver-stage malaria infection in primary human hepatocytes in vitro.”, Dis Model Mech, vol. 7, no. 2, pp. 215-24, 2014. PDF icon Full Text + Supporting Info


2013

G. A. Kwong, von Maltzahn, G., Murugappan, G., Abudayyeh, O., Mo, S., Papayannopoulos, I. A., Sverdlov, D. Y., Liu, S. B., Warren, A. D., Popov, Y., Schuppan, D., and Bhatia, S. N., “Mass-encoded synthetic biomarkers for multiplexed urinary monitoring of disease.”, Nat Biotechnol, vol. 31, no. 1, pp. 63-70, 2013. PDF icon Full Text + Supporting Info
S. Hauert, Berman, S., Nagpal, R., and Bhatia, S. N., “A computational framework for identifying design guidelines to increase the penetration of targeted nanoparticles into tumors.”, Nano Today, vol. 8, no. 6, pp. 566-576, 2013. PDF icon Full Text
G. Vunjak-Novakovic, Bhatia, S. N., Chen, C., and Hirschi, K., “HeLiVa platform: integrated heart-liver-vascular systems for drug testing in human health and disease.”, Stem Cell Res Ther, vol. 4 Suppl 1, p. S8, 2013. PDF icon Full Text
K. Y. Lin, Kwong, G. A., Warren, A. D., Wood, D. K., and Bhatia, S. N., “Nanoparticles that sense thrombin activity as synthetic urinary biomarkers of thrombosis.”, ACS Nano, vol. 7, no. 10, pp. 9001-9, 2013. PDF icon Full Text + Supporting Info
A. F. Bagley, Hill, S., Rogers, G. S., and Bhatia, S. N., “Plasmonic photothermal heating of intraperitoneal tumors through the use of an implanted near-infrared source.”, ACS Nano, vol. 7, no. 9, pp. 8089-97, 2013. PDF icon Full Text + Supporting Info
T. Danino†, Prindle†, A., Hasty, J., and Bhatia, S. N., “Measuring growth and gene expression dynamics of tumor-targeted S. typhimurium bacteria.”, J Vis Exp, no. 77, p. e50540, 2013. PDF icon Full Text
S. March, Ng, S., Velmurugan, S., Galstian, A., Shan, J., Logan, D. J., Carpenter, A. E., Thomas, D., B Sim, K. Lee, Mota, M. M., Hoffman, S. L., and Bhatia, S. N., “A microscale human liver platform that supports the hepatic stages of Plasmodium falciparum and vivax.”, Cell Host Microbe, vol. 14, no. 1, pp. 104-15, 2013. PDF icon Full Text + Supporting Info
I. Y. Wong, Bhatia, S. N., and Toner, M., “Nanotechnology: emerging tools for biology and medicine.”, Genes Dev, vol. 27, no. 22, pp. 2397-408, 2013. PDF icon Full Text
J. Lo†, von Maltzahn†, G., Douglass, J., Park, J. - H., Sailor, M. J., Ruoslahti, E., and Bhatia, S. N., “Nanoparticle amplification via photothermal unveiling of cryptic collagen binding sites.”, J Mater Chem B Mater Biol Med, vol. 1, no. 39, pp. 5235-5240, 2013. PDF icon Full Text
J. Shan, Schwartz, R. E., Ross, N. T., Logan, D. J., Thomas, D., Duncan, S. A., North, T. E., Goessling, W., Carpenter, A. E., and Bhatia, S. N., “Identification of small molecules for human hepatocyte expansion and iPS differentiation.”, Nat Chem Biol, vol. 9, no. 8, pp. 514-20, 2013. PDF icon Full Text + Supporting Info
S. P. Desai, Bhatia, S. N., Toner, M., and Irimia, D., “Mitochondrial localization and the persistent migration of epithelial cancer cells.”, Biophys J, vol. 104, no. 9, pp. 2077-88, 2013. PDF icon Full Text + Supporting Info
J. D. Baranski†, Chaturvedi†, R. R., Stevens†, K. R., Eyckmans, J., Carvalho, B., Solorzano, R. D., Yang, M. T., Miller, J. S., Bhatia, S. N., and Chen, C. S., “Geometric control of vascular networks to enhance engineered tissue integration and function.”, Proc Natl Acad Sci U S A, vol. 110, no. 19, pp. 7586-91, 2013. PDF icon Full Text + Supporting Info
K. R. Stevens, Ungrin, M. D., Schwartz, R. E., Ng, S., Carvalho, B., Christine, K. S., Chaturvedi, R. R., Li, C. Y., Zandstra, P. W., Chen, C. S., and Bhatia, S. N., “InVERT molding for scalable control of tissue microarchitecture.”, Nat Commun, vol. 4, p. 1847, 2013. PDF icon Full Text + Supporting Info, PDF icon Featured in Nature
C. Y. Li†, Wood†, D. K., Huang, J. H., and Bhatia, S. N., “Flow-based pipeline for systematic modulation and analysis of 3D tumor microenvironments.”, Lab Chip, vol. 13, no. 10, pp. 1969-78, 2013. PDF icon Full Text + Supporting Info


2012

G. D. Prestwich, Bhatia, S. N., Breuer, C. K., Dahl, S. L. M., Mason, C., McFarland, R., McQuillan, D. J., Sackner-Bernstein, J., Schox, J., Tente, W. E., and Trounson, A., “What is the greatest regulatory challenge in the translation of biomaterials to the clinic?”, Sci Transl Med, vol. 4, no. 160, p. 160cm14, 2012. PDF icon Full Text
T. Danino, Lo, J., Prindle, A., Hasty, J., and Bhatia, S. N., “In Vivo Gene Expression Dynamics of Tumor-Targeted Bacteria.”, ACS Synth Biol, vol. 1, no. 10, pp. 465-470, 2012. PDF icon Full Text + Supporting Info
A. Prindle, Selimkhanov, J., Danino, T., Samayoa, P., Goldberg, A., Bhatia, S. N., and Hasty, J., “Genetic Circuits in Salmonella typhimurium.”, ACS Synth Biol, vol. 1, no. 10, pp. 458-464, 2012. PDF icon Full Text + Supporting Info
G. H. Underhill, Galie, P., Chen, C. S., and Bhatia, S. N., “Bioengineering methods for analysis of cells in vitro.”, Annu Rev Cell Dev Biol, vol. 28, pp. 385-410, 2012. PDF icon Full Text
N. E. Reticker-Flynn, Malta, D. F. Braga, Winslow, M. M., Lamar, J. M., Xu, M. J., Underhill, G. H., Hynes, R. O., Jacks, T. E., and Bhatia, S. N., “A combinatorial extracellular matrix platform identifies cell-extracellular matrix interactions that correlate with metastasis.”, Nat Commun, vol. 3, p. 1122, 2012. PDF icon Full Text + Supporting Info, PDF icon Featured in Nature
C. P. El-Haibi, Bell, G. W., Zhang, J., Collmann, A. Y., Wood, D., Scherber, C. M., Csizmadia, E., Mariani, O., Zhu, C., Campagne, A., Toner, M., Bhatia, S. N., Irimia, D., Vincent-Salomon, A., and Karnoub, A. E., “Critical role for lysyl oxidase in mesenchymal stem cell-driven breast cancer malignancy.”, Proc Natl Acad Sci U S A, vol. 109, no. 43, pp. 17460-5, 2012. PDF icon Full Text + Supporting Info
Y. Ren, Hauert, S., Lo, J., and Bhatia, S. N., “Identification and characterization of receptor-specific peptides for siRNA delivery.”, ACS Nano, vol. 6, no. 10, pp. 8620-31, 2012. PDF icon Full Text + Supporting Info
D. Nijhawan, Zack, T. I., Ren, Y., Strickland, M. R., Lamothe, R., Schumacher, S. E., Tsherniak, A., Besche, H. C., Rosenbluh, J., Shehata, S., Cowley, G. S., Weir, B. A., Goldberg, A. L., Mesirov, J. P., Root, D. E., Bhatia, S. N., Beroukhim, R., and Hahn, W. C., “Cancer vulnerabilities unveiled by genomic loss.”, Cell, vol. 150, no. 4, pp. 842-54, 2012. PDF icon Full Text + Supporting Info
Y. Ren†, Cheung†, H. Wing, von Maltzahn, G., Agrawal, A., Cowley, G. S., Weir, B. A., Boehm, J. S., Tamayo, P., Karst, A. M., Liu, J. F., Hirsch, M. S., Mesirov, J. P., Drapkin, R., Root, D. E., Lo, J., Fogal, V., Ruoslahti, E., Hahn‡, W. C., and Bhatia‡, S. N., “Targeted tumor-penetrating siRNA nanocomplexes for credentialing the ovarian cancer oncogene ID4.”, Sci Transl Med, vol. 4, no. 147, p. 147ra112, 2012. PDF icon Full Text + Supporting Info
S. N. Bhatia, Frangioni, J. V., Hoffman, R. M., A Iafrate, J., and Polyak, K., “The challenges posed by cancer heterogeneity.”, Nat Biotechnol, vol. 30, no. 7, pp. 604-10, 2012. PDF icon Full Text
J. S. Miller, Stevens, K. R., Yang, M. T., Baker, B. M., Nguyen, D. - H. T., Cohen, D. M., Toro, E., Chen, A. A., Galie, P. A., Yu, X., Chaturvedi, R., Bhatia, S. N., and Chen, C. S., “Rapid casting of patterned vascular networks for perfusable engineered three-dimensional tissues.”, Nat Mater, vol. 11, no. 9, pp. 768-74, 2012. PDF icon Full Text + Supporting Info
D. K. Wood, Soriano, A., Mahadevan, L., Higgins, J. M., and Bhatia, S. N., “A biophysical indicator of vaso-occlusive risk in sickle cell disease.”, Sci Transl Med, vol. 4, no. 123, p. 123ra26, 2012. PDF icon Full Text + Supporting Info
R. E. Schwartz†, Trehan†, K., Andrus, L., Sheahan, T. P., Ploss, A., Duncan, S. A., Rice‡, C. M., and Bhatia‡, S. N., “Modeling hepatitis C virus infection using human induced pluripotent stem cells.”, Proc Natl Acad Sci U S A, vol. 109, no. 7, pp. 2544-8, 2012. PDF icon Full Text + Supporting Info


2011

L. Andrus, Marukian, S., Jones, C. T., Catanese, M. Teresa, Sheahan, T. P., Schoggins, J. W., Barry, W. T., Dustin, L. B., Trehan, K., Ploss, A., Bhatia, S. N., and Rice, C. M., “Expression of paramyxovirus V proteins promotes replication and spread of hepatitis C virus in cultures of primary human fetal liver cells.”, Hepatology, vol. 54, no. 6, pp. 1901-12, 2011. PDF icon Full Text
N. Singh, Karambelkar, A., Gu, L., Lin, K. Y., Miller, J. S., Chen, C. S., Sailor, M. J., and Bhatia, S. N., “Bioresponsive mesoporous silica nanoparticles for triggered drug release.”, J Am Chem Soc, vol. 133, no. 49, pp. 19582-5, 2011. PDF icon Full Text + Supporting Info
C. Y. Li, Wood, D. K., Hsu, C. M., and Bhatia, S. N., “DNA-templated assembly of droplet-derived PEG microtissues.”, Lab Chip, vol. 11, no. 17, pp. 2967-75, 2011. PDF icon Full Text + Supporting Info
A. A. Chen, Thomas, D. K., Ong, L. L., Schwartz, R. E., Golub, T. R., and Bhatia, S. N., “Humanized mice with ectopic artificial liver tissues.”, Proc Natl Acad Sci U S A, vol. 108, no. 29, pp. 11842-7, 2011. PDF icon Full Text + Supplement
H. Wing Cheung, Cowley, G. S., Weir, B. A., Boehm, J. S., Rusin, S., Scott, J. A., East, A., Ali, L. D., Lizotte, P. H., Wong, T. C., Jiang, G., Hsiao, J., Mermel, C. H., Getz, G., Barretina, J., Gopal, S., Tamayo, P., Gould, J., Tsherniak, A., Stransky, N., Luo, B., Ren, Y., Drapkin, R., Bhatia, S. N., Mesirov, J. P., Garraway, L. A., Meyerson, M., Lander, E. S., Root, D. E., and Hahn, W. C., “Systematic investigation of genetic vulnerabilities across cancer cell lines reveals lineage-specific dependencies in ovarian cancer.”, Proc Natl Acad Sci U S A, vol. 108, no. 30, pp. 12372-7, 2011. PDF icon Full Text + Supplement
G. von Maltzahn, Park, J. - H., Lin, K. Y., Singh, N., Schwöppe, C., Mesters, R., Berdel, W. E., Ruoslahti, E., Sailor, M. J., and Bhatia, S. N., “Nanoparticles that communicate in vivo to amplify tumour targeting.”, Nat Mater, vol. 10, no. 7, pp. 545-52, 2011. PDF icon Full Text + Supporting Info
T. Danino, Volfson, D., Bhatia, S. N., Tsimring, L., and Hasty, J., “In-silico patterning of vascular mesenchymal cells in three dimensions.”, PLoS One, vol. 6, no. 5, p. e20182, 2011. PDF icon Full Text
M. S. Goldberg, Xing, D., Ren, Y., Orsulic, S., Bhatia, S. N., and Sharp, P. A., “Nanoparticle-mediated delivery of siRNA targeting Parp1 extends survival of mice bearing tumors derived from Brca1-deficient ovarian cancer cells.”, Proc Natl Acad Sci U S A, vol. 108, no. 2, pp. 745-50, 2011. PDF icon Full Text + Supplement


2010

K. Y. Lin†, Bagley†, A. F., Zhang, A. Y., Karl, D. L., Yoon, S. S., and Bhatia, S. N., “Gold nanorod photothermal therapy in a genetically engineered mouse model of soft tissue sarcoma”, Nano LIFE, vol. 01, no. 03n04, pp. 277 - 287, 2010. PDF icon Full Text + Supplement
A. A. Chen, Underhill, G. H., and Bhatia, S. N., “Multiplexed, high-throughput analysis of 3D microtissue suspensions.”, Integr Biol (Camb), vol. 2, no. 10, pp. 517-27, 2010. PDF icon Full Text + Supporting Info
Z. Poon, Chen, S., Engler, A. C., Lee, H. -il, Atas, E., von Maltzahn, G., Bhatia, S. N., and Hammond, P. T., “Ligand-clustered "patchy" nanoparticles for modulated cellular uptake and in vivo tumor targeting.”, Angew Chem Int Ed Engl, vol. 49, no. 40, pp. 7266-70, 2010. PDF icon Full Text + Supporting Info
D. K. Wood, Weingeist, D. M., Bhatia‡, S. N., and Engelward‡, B. P., “Single cell trapping and DNA damage analysis using microwell arrays.”, Proc Natl Acad Sci U S A, vol. 107, no. 22, pp. 10008-13, 2010. PDF icon Full Text + Supporting Info
D. R. Albrecht†, Underhill†, G. H., Resnikoff, J., Mendelson, A., Bhatia, S. N., and Shah, J. V., “Microfluidics-integrated time-lapse imaging for analysis of cellular dynamics.”, Integr Biol (Camb), vol. 2, no. 5-6, pp. 278-87, 2010. PDF icon Full Text + Supporting Info
N. Singh, Agrawal, A., Leung, A. K. L., Sharp, P. A., and Bhatia, S. N., “Effect of nanoparticle conjugation on gene silencing by RNA interference.”, J Am Chem Soc, vol. 132, no. 24, pp. 8241-3, 2010. PDF icon Full Text + Supporting Info
E. Ruoslahti, Bhatia, S. N., and Sailor, M. J., “Targeting of drugs and nanoparticles to tumors.”, J Cell Biol, vol. 188, no. 6, pp. 759-68, 2010. PDF icon Full Text
J. - H. Park, von Maltzahn, G., Ong, L. L., Centrone, A., T Hatton, A., Ruoslahti, E., Bhatia, S. N., and Sailor, M. J., “Cooperative nanoparticles for tumor detection and photothermally triggered drug delivery.”, Adv Mater, vol. 22, no. 8, pp. 880-5, 2010. PDF icon Full Text + Supporting Info
N. C. Chesler, Barabino, G., Bhatia, S. N., and Richards-Kortum, R., “The pipeline still leaks and more than you think: a status report on gender diversity in biomedical engineering.”, Ann Biomed Eng, vol. 38, no. 5, pp. 1928-35, 2010. PDF icon Full Text
A. Ploss†, Khetani†, S. R., Jones, C. T., Syder, A. J., Trehan, K., Gaysinskaya, V. A., Mu, K., Ritola, K., Rice‡, C. M., and Bhatia‡, S. N., “Persistent hepatitis C virus infection in microscale primary human hepatocyte cultures.”, Proc Natl Acad Sci U S A, vol. 107, no. 7, pp. 3141-5, 2010. PDF icon Full Text + Supporting Info
C. T. Jones, Catanese, M. Teresa, Law, L. Man J., Khetani, S. R., Syder, A. J., Ploss, A., Oh, T. S., Schoggins, J. W., MacDonald, M. R., Bhatia, S. N., and Rice, C. M., “Real-time imaging of hepatitis C virus infection using a fluorescent cell-based reporter system.”, Nat Biotechnol, vol. 28, no. 2, pp. 167-71, 2010. PDF icon Full Text + Supporting Info
J. - H. Park, von Maltzahn, G., Xu, M. Jue, Fogal, V., Kotamraju, V. Ramana, Ruoslahti, E., Bhatia, S. N., and Sailor, M. J., “Cooperative nanomaterial system to sensitize, target, and treat tumors.”, Proc Natl Acad Sci U S A, vol. 107, no. 3, pp. 981-6, 2010. PDF icon Full Text + Supporting Info
T. J. Harris†, Green†, J. J., Fung, P. W., Langer, R., Anderson‡, D. G., and Bhatia‡, S. N., “Tissue-specific gene delivery via nanoparticle coating.”, Biomaterials, vol. 31, no. 5, pp. 998-1006, 2010. PDF icon Full Text


2009

D. DasGupta, von Maltzahn, G., Ghosh, S., Bhatia, S. N., Das, S. K., and Chakraborty, S., “Probing nanoantenna-directed photothermal destruction of tumors using noninvasive laser irradiation”, Applied Physics Letters, vol. 95, p. -, 2009. PDF icon Full Text
G. von Maltzahn, Centrone, A., Park, J. - H., Ramanathan, R., Sailor, M. J., T Hatton, A., and Bhatia, S. N., “SERS-Coded Gold Nanorods as a Multifunctional Platform for Densely Multiplexed Near-Infrared Imaging and Photothermal Heating.”, Adv Mater, vol. 21, no. 31, pp. 3175-3180, 2009. PDF icon Full Text + Supporting Info
J. W. Aptekar, Cassidy, M. C., Johnson, A. C., Barton, R. A., Lee, M., Ogier, A. C., Vo, C., Anahtar, M. N., Ren, Y., Bhatia, S. N., Ramanathan, C., Cory, D. G., Hill, A. L., Mair, R. W., Rosen, M. S., Walsworth, R. L., and Marcus, C. M., “Silicon nanoparticles as hyperpolarized magnetic resonance imaging agents.”, ACS Nano, vol. 3, no. 12, pp. 4003-8, 2009. PDF icon Full Text + Supporting Info
A. Agrawal, Min, D. - H., Singh, N., Zhu, H., Birjiniuk, A., von Maltzahn, G., Harris, T. J., Xing, D., Woolfenden, S. D., Sharp, P. A., Charest, A., and Bhatia, S. N., “Functional delivery of siRNA in mice using dendriworms.”, ACS Nano, vol. 3, no. 9, pp. 2495-504, 2009. PDF icon Full Text + Supporting Info
S. March, Hui, E. E., Underhill, G. H., Khetani, S., and Bhatia, S. N., “Microenvironmental regulation of the sinusoidal endothelial cell phenotype in vitro.”, Hepatology, vol. 50, no. 3, pp. 920-8, 2009. PDF icon Full Text + Supporting Info
D. Simberg, Park, J. - H., Karmali, P. P., Zhang, W. - M., Merkulov, S., McCrae, K., Bhatia, S. N., Sailor, M., and Ruoslahti, E., “Differential proteomics analysis of the surface heterogeneity of dextran iron oxide nanoparticles and the implications for their in vivo clearance.”, Biomaterials, vol. 30, no. 23-24, pp. 3926-33, 2009. PDF icon Full Text + Supporting Information, Office spreadsheet icon Supplemental Data 1, Office spreadsheet icon Supplemental Data 2, Office spreadsheet icon Supplemental Data 3, Office spreadsheet icon Supplemental Data 4
G. von Maltzahn, Park, J. - H., Agrawal, A., Bandaru, N. Kishor, Das, S. K., Sailor, M. J., and Bhatia, S. N., “Computationally guided photothermal tumor therapy using long-circulating gold nanorod antennas.”, Cancer Res, vol. 69, no. 9, pp. 3892-900, 2009. PDF icon Full Text + Supporting Information
J. - H. Park, von Maltzahn, G., Zhang, L., Derfus, A. M., Simberg, D., Harris, T. J., Ruoslahti, E., Bhatia, S. N., and Sailor, M. J., “Systematic surface engineering of magnetic nanoworms for in vivo tumor targeting.”, Small, vol. 5, no. 6, pp. 694-700, 2009. PDF icon Full Text + Supporting Information
J. - H. Park, Gu, L., von Maltzahn, G., Ruoslahti, E., Bhatia, S. N., and Sailor, M. J., “Biodegradable luminescent porous silicon nanoparticles for in vivo applications.”, Nat Mater, vol. 8, no. 4, pp. 331-6, 2009. PDF icon Full Text + Supporting Information
J. M. Higgins, Eddington, D. T., Bhatia, S. N., and Mahadevan, L., “Statistical dynamics of flowing red blood cells by morphological image processing.”, PLoS Comput Biol, vol. 5, no. 2, p. e1000288, 2009. PDF icon Full Text
A. A. Chen, Khetani, S. R., Lee, S., Bhatia, S. N., and Van Vliet, K. J., “Modulation of hepatocyte phenotype in vitro via chemomechanical tuning of polyelectrolyte multilayers.”, Biomaterials, vol. 30, no. 6, pp. 1113-20, 2009. PDF icon Full Text + Supporting Information
S. D. Alvarez, Derfus, A. M., Schwartz, M. P., Bhatia, S. N., and Sailor, M. J., “The compatibility of hepatocytes with chemically modified porous silicon with reference to in vitro biosensors.”, Biomaterials, vol. 30, no. 1, pp. 26-34, 2009. PDF icon Full Text


2008

J. - H. Park, von Maltzahn, G., Ruoslahti, E., Bhatia, S. N., and Sailor, M. J., “Micellar hybrid nanoparticles for simultaneous magnetofluorescent imaging and drug delivery.”, Angew Chem Int Ed Engl, vol. 47, no. 38, pp. 7284-8, 2008. PDF icon Full Text, PDF icon Supporting Information
T. J. Harris, von Maltzahn, G., Lord, M. E., Park, J. - H., Agrawal, A., Min, D. - H., Sailor, M. J., and Bhatia, S. N., “Protease-triggered unveiling of bioactive nanoparticles.”, Small, vol. 4, no. 9, pp. 1307-12, 2008. PDF icon Full Text, PDF icon Supporting Information
S. R. Khetani, Chen, A. A., Ranscht, B., and Bhatia, S. N., “T-cadherin modulates hepatocyte functions in vitro.”, FASEB J, vol. 22, no. 11, pp. 3768-75, 2008. PDF icon Full Text, PDF icon Supporting Information
G. von Maltzahn, Ren, Y., Park, J. - H., Min, D. - H., Kotamraju, V. Ramana, Jayakumar, J., Fogal, V., Sailor, M. J., Ruoslahti, E., and Bhatia, S. N., “In vivo tumor cell targeting with "click" nanoparticles.”, Bioconjug Chem, vol. 19, no. 8, pp. 1570-8, 2008. PDF icon Full Text, PDF icon Supporting Information
J. - H. Park, von Maltzahn, G., Zhang, L., Schwartz, M. P., Ruoslahti, E., Bhatia, S. N., and Sailor, M. J., “Magnetic Iron Oxide Nanoworms for Tumor Targeting and Imaging.”, Adv Mater, vol. 20, no. 9, pp. 1630-1635, 2008. PDF icon Full Text
C. J. Flaim, Teng, D., Chien, S., and Bhatia, S. N., “Combinatorial signaling microenvironments for studying stem cell fate.”, Stem Cells Dev, vol. 17, no. 1, pp. 29-39, 2008. PDF icon Full Text
S. R. Khetani and Bhatia, S. N., “Microscale culture of human liver cells for drug development.”, Nat Biotechnol, vol. 26, no. 1, pp. 120-6, 2008. PDF icon Full Text + Supplement


2007

G. von Maltzahn, Min, D. - H., Zhang, Y., Park, J. - H., Harris, T. J., Sailor, M. J., and Bhatia, S. N., “Nanoparticle Self-Assembly Directed by Antagonistic Kinase and Phosphatase Activities”, Advanced Materials, vol. 19, no. 21, pp. 3579–3583, 2007. PDF icon Full Text
J. M. Higgins, Eddington, D. T., Bhatia, S. N., and Mahadevan, L., “Sickle cell vasoocclusion and rescue in a microfluidic device.”, Proc Natl Acad Sci U S A, vol. 104, no. 51, pp. 20496-500, 2007. PDF icon Higgins_PNAS_2007.pdf
A. M. Derfus, von Maltzahn, G., Harris, T. J., Duza, T., Vecchio, K. S., Ruoslahti, E., and Bhatia, S. N., “Remotely Triggered Release from Magnetic Nanoparticles”, Advanced Materials, vol. 19, no. 22, pp. 3932–3936, 2007. PDF icon Full Text
E. E. Hui and Bhatia, S. N., “Silicon microchips for manipulating cell-cell interaction.”, J Vis Exp, no. 7, p. 268, 2007. PDF icon Full Text
G. H. Underhill and Bhatia, S. N., “High-throughput analysis of signals regulating stem cell fate and function.”, Curr Opin Chem Biol, vol. 11, no. 4, pp. 357-66, 2007. PDF icon Full Text
A. M. Derfus, Chen, A. A., Min, D. - H., Ruoslahti, E., and Bhatia, S. N., “Targeted quantum dot conjugates for siRNA delivery.”, Bioconjug Chem, vol. 18, no. 5, pp. 1391-6, 2007. PDF icon Full Text
A. R. Evans, Euteneuer, S., Chavez, E., Mullen, L. M., Hui, E. E., Bhatia, S. N., and Ryan, A. F., “Laminin and fibronectin modulate inner ear spiral ganglion neurite outgrowth in an in vitro alternate choice assay.”, Dev Neurobiol, vol. 67, no. 13, pp. 1721-30, 2007. PDF icon Full Text
D. R. Albrecht, Underhill, G. H., Mendelson, A., and Bhatia, S. N., “Multiphase electropatterning of cells and biomaterials.”, Lab Chip, vol. 7, no. 6, pp. 702-9, 2007. PDF icon Full Text
G. von Maltzahn, Harris, T. J., Park, J. - H., Min, D. - H., Schmidt, A. J., Sailor, M. J., and Bhatia, S. N., “Nanoparticle self-assembly gated by logical proteolytic triggers.”, J Am Chem Soc, vol. 129, no. 19, pp. 6064-5, 2007. PDF icon Full Text, PDF icon Supporting Information
E. E. Hui and Bhatia, S. N., “Micromechanical control of cell-cell interactions.”, Proc Natl Acad Sci U S A, vol. 104, no. 14, pp. 5722-6, 2007. PDF icon Full Text + Supplement
E. E. Hui and Bhatia, S. N., “Microscale control of cell contact and spacing via three-component surface patterning.”, Langmuir, vol. 23, no. 8, pp. 4103-7, 2007. PDF icon Full Text
D. Simberg, Duza, T., Park, J. Ho, Essler, M., Pilch, J., Zhang, L., Derfus, A. M., Yang, M., Hoffman, R. M., Bhatia, S. N., Sailor, M. J., and Ruoslahti, E., “Biomimetic amplification of nanoparticle homing to tumors.”, Proc Natl Acad Sci U S A, vol. 104, no. 3, pp. 932-6, 2007. PDF icon Full Text
V. Liu Tsang, Chen, A. A., Cho, L. M., Jadin, K. D., Sah, R. L., DeLong, S., West, J. L., and Bhatia, S. N., “Fabrication of 3D hepatic tissues by additive photopatterning of cellular hydrogels.”, FASEB J, vol. 21, no. 3, pp. 790-801, 2007. PDF icon Full Text, PDF icon Supporting Information1, PDF icon Supporting Information2
V. Liu Tsang and Bhatia, S. N., “Fabrication of three-dimensional tissues.”, Adv Biochem Eng Biotechnol, vol. 103, pp. 189-205, 2007.
G. H. Underhill, Chen, A. A., Albrecht, D. R., and Bhatia, S. N., “Assessment of hepatocellular function within PEG hydrogels.”, Biomaterials, vol. 28, no. 2, pp. 256-70, 2007. PDF icon Full Text


2006

J. W. Allen, Khetani, S. R., Johnson, R. S., and Bhatia, S. N., “In vitro liver tissue model established from transgenic mice: role of HIF-1alpha on hypoxic gene expression.”, Tissue Eng, vol. 12, no. 11, pp. 3135-47, 2006. PDF icon Full Text
S. R. Khetani and Bhatia, S. N., “Engineering tissues for in vitro applications.”, Curr Opin Biotechnol, vol. 17, no. 5, pp. 524-31, 2006. PDF icon Full Text
M. P. Schwartz, Derfus, A. M., Alvarez, S. D., Bhatia, S. N., and Sailor, M. J., “The smart Petri dish: a nanostructured photonic crystal for real-time monitoring of living cells.”, Langmuir, vol. 22, no. 16, pp. 7084-90, 2006. PDF icon Full Text
J. - H. Park, Derfus, A. M., Segal, E., Vecchio, K. S., Bhatia, S. N., and Sailor, M. J., “Local heating of discrete droplets using magnetic porous silicon-based photonic crystals.”, J Am Chem Soc, vol. 128, no. 24, pp. 7938-46, 2006. PDF icon Full Text
T. J. Harris, von Maltzahn, G., Derfus, A. M., Ruoslahti, E., and Bhatia, S. N., “Proteolytic actuation of nanoparticle self-assembly.”, Angew Chem Int Ed Engl, vol. 45, no. 19, pp. 3161-5, 2006. PDF icon Full Text
D. R. Albrecht, Underhill, G. H., Wassermann, T. B., Sah, R. L., and Bhatia, S. N., “Probing the role of multicellular organization in three-dimensional microenvironments.”, Nat Methods, vol. 3, no. 5, pp. 369-75, 2006. PDF icon Full Text + Supplement


2005

A. A. Chen, Derfus, A. M., Khetani, S. R., and Bhatia, S. N., “Quantum dots to monitor RNAi delivery and improve gene silencing.”, Nucleic Acids Res, vol. 33, no. 22, p. e190, 2005. PDF icon Full Text
C. J. Flaim, Chien, S., and Bhatia, S. N., “An extracellular matrix microarray for probing cellular differentiation.”, Nat Methods, vol. 2, no. 2, pp. 119-25, 2005. PDF icon Full Text, PDF icon Supporting Information
D. R. Albrecht, Tsang, V. Liu, Sah, R. L., and Bhatia, S. N., “Photo- and electropatterning of hydrogel-encapsulated living cell arrays.”, Lab Chip, vol. 5, no. 1, pp. 111-8, 2005. PDF icon Full Text
J. W. Allen, Khetani, S. R., and Bhatia, S. N., “In vitro zonation and toxicity in a hepatocyte bioreactor.”, Toxicol Sci, vol. 84, no. 1, pp. 110-9, 2005. PDF icon Full Text
J. W. Allen, Johnson, R. S., and Bhatia, S. N., “Hypoxic inhibition of 3-methylcholanthrene-induced CYP1A1 expression is independent of HIF-1alpha.”, Toxicol Lett, vol. 155, no. 1, pp. 151-9, 2005. PDF icon Full Text


2004

A.  M. Derfus, Chan, W.  C.  W., and Bhatia, S. N., “Intracellular Delivery of Quantum Dots for Live Cell Labeling and Organelle Tracking”, Advanced Materials, vol. 16, pp. 961–966, 2004. PDF icon Full Text
A. M. Derfus, Chan, W. C. W., and Bhatia, S. N., “Probing the Cytotoxicity of Semiconductor Quantum Dots”, Nano Letters, vol. 4, pp. 11-18, 2004. PDF icon Full Text
J. R. Dorvee, Derfus, A. M., Bhatia, S. N., and Sailor, M. J., “Manipulation of liquid droplets using amphiphilic, magnetic one-dimensional photonic crystal chaperones.”, Nat Mater, vol. 3, no. 12, pp. 896-9, 2004. PDF icon Full Text
V. I. Chin, Taupin, P., Sanga, S., Scheel, J., Gage, F. H., and Bhatia, S. N., “Microfabricated platform for studying stem cell fates.”, Biotechnol Bioeng, vol. 88, no. 3, pp. 399-415, 2004. PDF icon Full Text
D. R. Albrecht, Sah, R. L., and Bhatia, S. N., “Geometric and material determinants of patterning efficiency by dielectrophoresis.”, Biophys J, vol. 87, no. 4, pp. 2131-47, 2004. PDF icon Full Text
P. Lin, Chan, W. C. W., Badylak, S. F., and Bhatia, S. N., “Assessing porcine liver-derived biomatrix for hepatic tissue engineering.”, Tissue Eng, vol. 10, no. 7-8, pp. 1046-53, 2004. PDF icon Full Text
V. Liu Tsang and Bhatia, S. N., “Three-dimensional tissue fabrication.”, Adv Drug Deliv Rev, vol. 56, no. 11, pp. 1635-47, 2004. PDF icon Full Text
S. R. Khetani, Szulgit, G., Del Rio, J. A., Barlow, C., and Bhatia, S. N., “Exploring interactions between rat hepatocytes and nonparenchymal cells using gene expression profiling.”, Hepatology, vol. 40, no. 3, pp. 545-54, 2004. PDF icon Full Text


2003

G. Vozzi, Flaim, C., Ahluwalia, A., and Bhatia, S. N., “Fabrication of PLGA scaffolds using soft lithography and microsyringe deposition.”, Biomaterials, vol. 24, no. 14, pp. 2533-40, 2003. PDF icon Full Text
Y. Yang Li, Cunin, F., Link, J. R., Gao, T., Betts, R. E., Reiver, S. H., Chin, V., Bhatia, S. N., and Sailor, M. J., “Polymer replicas of photonic porous silicon for sensing and drug delivery applications.”, Science, vol. 299, no. 5615, pp. 2045-7, 2003. PDF icon Full Text
J. W. Allen and Bhatia, S. N., “Formation of steady-state oxygen gradients in vitro: application to liver zonation.”, Biotechnol Bioeng, vol. 82, no. 3, pp. 253-62, 2003. PDF icon Full Text
S. M. Gopalan, Flaim, C., Bhatia, S. N., Hoshijima, M., Knoell, R., Chien, K. R., Omens, J. H., and McCulloch, A. D., “Anisotropic stretch-induced hypertrophy in neonatal ventricular myocytes micropatterned on deformable elastomers.”, Biotechnol Bioeng, vol. 81, no. 5, pp. 578-87, 2003. PDF icon Full Text


2002

V. A. Liu and Bhatia, S. N., “Three-Dimensional Photopatterning of Hydrogels Containing Living Cells”, Biomedical Microdevices, vol. 4, no. 4, pp. 257 - 266, 2002. PDF icon Full Text
M. Ozkan, Pisanic, T., Scheel, J., Barlow, C., Esener, S., and Bhatia, S. N., “Electro-Optical Platform for the Manipulation of Live Cells”, Langmuir, vol. 19, no. 5, pp. 1532 - 1538, 2002. PDF icon Full Text
M. Ozkan, Bhatia, S. N., and Esener, S., “Optical Addressing of Polymer Beads for Chip-Based Systems”, Sensors and Materials, vol. 14, pp. 189–197, 2002. PDF icon Ozkan2002_SensorsMat.pdf
G. D. Heyman, Martyna, B., and Bhatia, S. N., “Gender and achievement-related beliefs among engineering students”, Journal of Women and Minorities in Science and Engineering, vol. 8, pp. 41–52, 2002. PDF icon Full Text
G. Vozzi, Flaim, C. J., Bianchi, F., Ahluwalia, A., and Bhatia, S. N., “Microfabricated PLGA scaffolds: a comparative study for application to tissue engineering”, Materials Science and Engineering: C, vol. 20, no. 1-2, pp. 43 - 47, 2002. PDF icon Full Text
F. Cunin, Schmedake, T. A., Link, J. R., Li, Y. Yang, Koh, J., Bhatia, S. N., and Sailor, M. J., “Biomolecular screening with encoded porous-silicon photonic crystals.”, Nat Mater, vol. 1, no. 1, pp. 39-41, 2002. PDF icon Full Text
J. W. Allen and Bhatia, S. N., “Improving the next generation of bioartificial liver devices.”, Semin Cell Dev Biol, vol. 13, no. 6, pp. 447-54, 2002. PDF icon Full Text
J. W. Allen and Bhatia, S. N., “Engineering liver therapies for the future.”, Tissue Eng, vol. 8, no. 5, pp. 725-37, 2002. PDF icon Full Text
M. E. Akerman, Chan, W. C. W., Laakkonen, P., Bhatia, S. N., and Ruoslahti, E., “Nanocrystal targeting in vivo.”, Proc Natl Acad Sci U S A, vol. 99, no. 20, pp. 12617-21, 2002. PDF icon Full Text
V. A. Liu, Jastromb, W. E., and Bhatia, S. N., “Engineering protein and cell adhesivity using PEO-terminated triblock polymers.”, J Biomed Mater Res, vol. 60, no. 1, pp. 126-34, 2002. PDF icon Full Text


2001

M. Ozkan, Ozkan, C. S., Kibar, O., Wang, M. M., Bhatia, S. N., and Esener, S., “Heterogeneous integration through electrokinetic migration”, Engineering in Medicine and Biology Magazine, IEEE, vol. 20, no. 6, pp. 144-151, 2001. PDF icon Full Text
M. Ozkan, Esener, S., and Bhatia, S. N., “Electrokinetic Assembly of Microsphere and Cellular Arrays”, Symposia LL/MM/NN/OO – Biomaterials for Drug Delivery & Tissue Engineering, 2001. PDF icon Full Text
V. Chin, Collins, B. E., Sailor, M. J., and Bhatia, S. N., “Compatibility of Primary Hepatocytes with Oxidized Nanoporous Silicon”, Advanced Materials, vol. 13, pp. 1877–1880, 2001. PDF icon Full Text
J. W. Allen, Hassanein, T., and Bhatia, S. N., “Advances in bioartificial liver devices.”, Hepatology, vol. 34, no. 3, pp. 447-55, 2001. PDF icon Full Text
S. Li, Bhatia, S. N., Hu, Y. L., Shiu, Y. T., Li, Y. S., Usami, S., and Chien, S., “Effects of morphological patterning on endothelial cell migration.”, Biorheology, vol. 38, no. 2-3, pp. 101-8, 2001. PDF icon Full Text


2000

K. Behnia, Bhatia, S. N., Jastromb, N., Balis, U., Sullivan, S., Yarmush, M., and Toner, M., “Xenobiotic metabolism by cultured primary porcine hepatocytes.”, Tissue Eng, vol. 6, no. 5, pp. 467-79, 2000. PDF icon Full Text


1999

S. N. Bhatia and Chen, C. S., “Tissue Engineering at the Micro-Scale”, Biomedical Microdevices, vol. 2, pp. 131-144, 1999. PDF icon Full Text
S. N. Bhatia, Balis, U. J., Yarmush, M. L., and Toner, M., “Effect of cell-cell interactions in preservation of cellular phenotype: cocultivation of hepatocytes and nonparenchymal cells.”, FASEB J, vol. 13, no. 14, pp. 1883-900, 1999. PDF icon Full Text
S. N. Bhatia, Suri, V., Bundy, A., and Krauss, C. M., “Prenatal detection and mapping of a distal 8p deletion associated with congenital heart disease.”, Prenat Diagn, vol. 19, no. 9, pp. 863-7, 1999. PDF icon Full Text
U. J. Balis, Behnia, K., Dwarakanath, B., Bhatia, S. N., Sullivan, S. J., Yarmush, M. L., and Toner, M., “Oxygen consumption characteristics of porcine hepatocytes.”, Metab Eng, vol. 1, no. 1, pp. 49-62, 1999. PDF icon Full Text
G. A. Ledezma, Folch, A., Bhatia, S. N., Balis, U. J., Yarmush, M. L., and Toner, M., “Numerical model of fluid flow and oxygen transport in a radial-flow microchannel containing hepatocytes.”, J Biomech Eng, vol. 121, no. 1, pp. 58-64, 1999. PDF icon Full Text


1998

S. N. Bhatia, Balis, U. J., Yarmush, M. L., and Toner, M., “Probing heterotypic cell interactions: hepatocyte function in microfabricated co-cultures.”, J Biomater Sci Polym Ed, vol. 9, no. 11, pp. 1137-60, 1998. PDF icon Full Text
S. N. Bhatia, Balis, U. J., Yarmush, M. L., and Toner, M., “Microfabrication of hepatocyte/fibroblast co-cultures: role of homotypic cell interactions.”, Biotechnol Prog, vol. 14, no. 3, pp. 378-87, 1998. PDF icon Full Text


1997

S. N. Bhatia, Yarmush, M. L., and Toner, M., “Engineered substrates for controlling cell-cell interactions”, Advances in Heat and Mass Transfer in Biotechnology, vol. ASME HTD-355, no. BED-37, pp. 99-103, 1997. PDF icon Full Text
S. N. Bhatia, Yarmush, M. L., and Toner, M., “Controlling cell interactions by micropatterning in co-cultures: hepatocytes and 3T3 fibroblasts.”, J Biomed Mater Res, vol. 34, no. 2, pp. 189-99, 1997. PDF icon Full Text


1996

S. N. Bhatia, Toner, M., Foy, B. D., Rotem, A., Tompkins, R. G., and Yarmush, M. L., “Zonal liver cell heterogeneity: effects of oxygen on metabolic functions of hepatocytes”, J Cell Eng, vol. 1, pp. 125-135, 1996. PDF icon Full Text


1994

S. N. Bhatia, Toner, M., Tompkins, R. G., and Yarmush, M. L., “Selective Adhesion of Hepatocytes on Patterned Surfaces”, Annals of the New York Academy of Sciences, vol. 745, no. 1204, pp. 187 - 209, 1994. PDF icon Full Text
A. Rotem, Toner, M., Bhatia, S. N., Foy, B. D., Tompkins, R. G., and Yarmush, M. L., “Oxygen is a factor determining in vitro tissue assembly: Effects on attachment and spreading of hepatocytes.”, Biotechnol Bioeng, vol. 43, no. 7, pp. 654-60, 1994. PDF icon Full Text