HeLiVa platform: integrated heart-liver-vascular systems for drug testing in human health and disease

Written By Melodi Anahtar

Publication Type:

Journal Article

Authors:

Vunjak-Novakovic‡, Gordana; Sangeeta N Bhatia; Chen, Christopher; Hirschi, Karen

Source:

Stem Cell Res Ther, Volume 4 Suppl 1, p.S8 (2013)

Abstract:

Our project team is developing an integrated microphysiological platform with functionally connected vascular, liver and cardiac microtissues derived from a single line of human pluripotent stem cells. The platform enables functional representation of human physiology in conjunction with real-time biological readouts (via imaging and homologous reporters for all three cell phenotypes) and compatibility with high-throughput/high-content analysis. In this paper, we summarize progress made over the first year of the grant.

Manuscript (PDF)

Melodi Anahtar
Previous

Nanoparticles that sense thrombin activity as synthetic urinary biomarkers of thrombosis
Next

A computational framework for Identifying design guidelines to increase the penetration of targeted nanoparticles into tumors